Browse by Aston Author

Article

Pararasa, Chathyan; Ikwuobe, John; Shigdar, Shahjahan; Boukouvalas, Alexis; Nabney, Ian T.; Brown, James E.; Devitt, Andrew; Bailey, Clifford J.; Bennett, Stuart J. and Griffiths, Helen R. (2016). Age-associated changes in long-chain fatty acid profile during healthy aging promote pro-inflammatory monocyte polarization via PPARγ. Aging Cell, 15 (1), pp. 128-139.

Dias, Irundika H.K.; Brown, Caroline L.R.; Polidori-Nelles, Maria Cristina; Lip, Gregory Y.H. and Griffiths, Helen R. (2015). LDL-Lipids from patients with hypercholesterolaemia and Alzheimer's disease are inflammatory to microvascular endothelial cells:mitigation by statin intervention. Clinical Science, 129 (12), pp. 1195-1206.

Bürkle, Alexander; Moreno-Villanueva, María; Bernhard, Jürgen; Blasco, María; Zondag, Gerben; Hoeijmakers, Jan H.J.; Toussaint, Olivier; Grubeck-Loebenstein, Beatrix; Mocchegiani, Eugenio; Collino, Sebastiano; Gonos, Efstathios S.; Sikora, Ewa; Gradinaru, Daniela; Dollé, Martijn; Salmon, Michel; Kristensen, Peter; Griffiths, Helen R.; Libert, Claude; Grune, Tilman; Breusing, Nicolle; Simm, Andreas; Franceschi, Claudio; Capri, Miriam; Talbot, Duncan; Caiafa, Paola; Friguet, Bertrand; Slagboom, P. Eline; Hervonen, Antti; Hurme, Mikko and Aspinall, Richard (2015). MARK-AGE biomarkers of ageing. Mechanisms of Ageing and Development, 151 , pp. 2-12.

McBean, Gethin J.; Aslan, Mutay; Griffiths, Helen R. and Torrão, Rita C (2015). Thiol redox homeostasis in neurodegenerative disease. Redox biology, 5 , pp. 186-194.

Perrie, Yvonne; Griffiths, Helen R. and Jones, David (2015). Enhancing vaccine design strategies:applications for protein science, proteomics and adjuvants. Journal of Pharmacy and Pharmacology, 67 (3), pp. 287-289.

Ruskovska, Tatjana; Bennett, Stuart J.; Brown, Caroline R.; Dimitrov, Slave; Kamcev, Nikola and Griffiths, Helen R. (2015). Ankyrin is the major oxidised protein in erythrocyte membranes from end-stage renal disease patients on chronic haemodialysis and oxidation is decreased by dialysis and vitamin C supplementation. Free Radical Research, 49 (2), pp. 175-185.

Pararasa, Chathyan; Bailey, Clifford J. and Griffiths, Helen R. (2015). Ageing, adipose tissue, fatty acids and inflammation. Biogerontology, 16 (2), pp. 235-248.

Marshall, Lindsay J.; Oguejiofor, Wilson; Willetts, Rachel S.; Griffiths, Helen R. and Devitt, Andrew (2015). Developing accurate models of the human airways. Journal of Pharmacy and Pharmacology, 67 (3), pp. 464-472.

Dunston, Christopher R.; Herbert, Rebecca and Griffiths, Helen R. (2015). Improving T cell-induced response to subunit vaccines:opportunities for a proteomic systems approach. Journal of Pharmacy and Pharmacology, 67 (3), pp. 290-299.

Griffiths, Helen R. and Lip, Gregory Y.H. (2014). New biomarkers and risk stratification in atrial fibrillation:simplicity and practicality matter. Circulation, 130 (21), pp. 1837-1839.

Dias, Irundika H.K.; Mistry, Jayna; Fell, Shaun; Reis, Ana; Spickett, Corinne M.; Polidori, Maria C; Lip, Greg Y.H. and Griffiths, Helen R. (2014). Oxidised LDL-lipids increase beta amyloid production by SH-SY5Y cells through glutathione depletion and lipid raft formation. Free Radical Biology and Medicine, 75 , 48–59.

Dias, Irundika H.K. and Griffiths, Helen R. (2014). Oxidative stress in diabetes - circulating advanced glycation end products, lipid oxidation and vascular disease. Annals of Clinical Biochemistry, 51 (2), pp. 125-127.

Griffiths, Helen R.; Dias, Irundika; Willetts, Rachel S. and Devitt, Andrew (2014). Redox regulation of protein damage in plasma. Redox biology, 2 (1), pp. 430-435.

Ratnayake, Shibani; Dias, Irundika H.K.; Lattmann, Eric and Griffiths, Helen R. (2013). Stabilising cysteinyl thiol oxidation and nitrosation for proteomic analysis. Journal of Proteomics, 92 , pp. 160-170.

Ghattas, Angie; Griffiths, Helen R.; Devitt, Andrew; Lip, Gregory Y.H. and Shantsila, Eduard (2013). Monocytes in coronary artery disease and atherosclerosis:where are we now? Journal of the American College of Cardiology, 62 (17), pp. 1541-1551.

Turner, James E.; Bennett, Stuart J.; Campbell, John P.; Bosch, Jos A.; Aldred, Sarah and Griffiths, Helen R. (2013). The antioxidant enzyme peroxiredoxin-2 is depleted in lymphocytes seven days after ultra-endurance exercise. Free Radical Research, 47 (10), pp. 821-828.

Dias, Irundika H.K.; Chapple, Ian L.C.; Milward, Mike; Grant, Melissa M.; Hill, Eric; Brown, James and Griffiths, Helen R. (2013). Sulforaphane restores cellular glutathione levels and reduces chronic periodontitis neutrophil hyperactivity in vitro. PLoS ONE, 8 (6),

Weber, Daniela; Milkovic, Lidija; Bennett, Stuart J.; Griffiths, Helen R.; Zarkovic, Neven and Grune, Tilman (2013). Measurement of HNE-protein adducts in human plasma and serum by ELISA-Comparison of two primary antibodies. Redox biology, 1 (1), pp. 226-233.

Kolamunne, Rajitha T.; Dias, Irundika H.K.; Vernallis, Ann B.; Grant, Melissa M. and Griffiths, Helen R. (2013). Nrf2 activation supports cell survival during hypoxia and hypoxia/reoxygenation in cardiomyoblasts; the roles of reactive oxygen and nitrogen species. Redox biology, 1 (1), pp. 418-426.

Dunston, Christopher R.; Choudhury, Khujesta and Griffiths, Helen R. (2012). Terminal galactose residues on transferrin are increased in mid-life adults compared to young adults. Proteomics, 12 (21), pp. 3147-3153.

Ghattas, Angie; Lip, Gregory Y.H.; Griffiths, Helen R. and Shantsila, Eduard S. (2012). Functional characteristics of monocytes subsets in the acute and healing phases of ST elevation myocardial infarction and their effect on ejection fraction. European Heart Journal, 33 (Suppl.), p. 787.

Ghattas, Angie; Lip, Gregory Y.H.; Griffiths, Helen R. and Shantsila, Eduard S. (2012). Predictive role of specific monocyte subsets for major adverse cardiac events after ST-elevation myocardial infarction. European Heart Journal, 33 (Suppl.), pp. 919-920.

Gao, Dan; Pararasa, Chathyan; Dunston, Christopher R; Bailey, Clifford J. and Griffiths, Helen R. (2012). Palmitate promotes monocyte atherogenicity via de novo ceramide synthesis. Free Radical Biology and Medicine, 53 (4), 796–806.

Akbar, Sarah; Bellary, Srikanth and Griffiths, Helen R. (2011). Dietary antioxidant interventions in type 2 diabetes patients:a meta-analysis. British Journal of Diabetes and Vascular Disease, 11 (2), pp. 62-68.

Polidori, M. Cristina; Pientka, Ludger; Nelles, Gereon and Griffiths, Helen R. (2010). Modulation of cholesterol in midlife affords cognitive advantage during ageing - a role for altered redox balance. International Journal of Clinical and Experimental Medicine, 3 (2), pp. 103-109.

Gao, Dan; Bailey, Clifford J. and Griffiths, Helen R. (2009). Metabolic memory effect of the saturated fatty acid, palmitate, in monocytes. Biochemical and Biophysical Research Communications, 388 (2), pp. 278-282.

Griffiths, Helen R. (2008). Is the generation of neo-antigenic determinants by free radicals central to the development of autoimmune rheumatoid disease? Autoimmunity Reviews, 7 (7), pp. 544-549.

Griffiths, Helen R.; Grune, Tilman; Gonos, Efstathios and Kartal-Ozer, Nesrin (2008). Report of Society for Free Radical Research Europe Summer School. Biofactors, 33 (2), pp. 157-160.

Grant, Melissa M.; Scheel-Toellner, D. and Griffiths, Helen R. (2007). Contributions to our understanding of T cell physiology through unveiling the T cell proteome. Clinical and Experimental Immunology, 149 (1), pp. 9-15.

Grant, Melissa M. and Griffiths, Helen R. (2007). Cell passage-associated transient high oxygenation causes a transient decrease in cellular glutathione and affects T cell responses to apoptotic and mitogenic stimuli. Environmental Toxicology and Pharmacology, 23 (3), pp. 335-339.

Polidori, M. Cristina; Griffiths, Helen R.; Mariani, E. and Mecocci, Patrizia (2007). Hallmarks of protein oxidative damage in neurodegenerative diseases:Focus on Alzheimer's disease. Amino Acids, 32 (4), pp. 553-559.

Zilz, Thomas R.; Griffiths, Helen R. and Coleman, Michael D. (2007). Apoptotic and necrotic effects of hexanedione derivatives on the human neuroblastoma line SK-N-SH. Toxicology, 231 (2-3), pp. 210-214.

Choudhury, Khujesta and Griffiths, Helen R. (2007). Dietary enrichment with almonds reduces oxidative stress and improves vascular function. Free Radical Research, 41 (s1), S21-S21.

Luan, Yingjun and Griffiths, Helen R. (2006). Ceramides reduce CD36 cell surface expression and oxidised LDL uptake by monocytes and macrophages. Archives of Biochemistry and Biophysics, 450 (1), pp. 89-99.

Williamson, Matthew R.; Woollard, Kevin J.; Griffiths, Helen R. and Coombes, Allan G.A. (2006). Gravity spun polycaprolactone fibers for applications in vascular tissue engineering:proliferation and function of human vascular endothelial cells. Tissue Engineering, 12 (1), pp. 45-51.

Griffiths, Helen R.; Aldred, Sarah; Dale, Chloe; Nakano, Emi; Kitas, George D.; Grant, Melissa G.; Nugent, Desmond; Taiwo, Fatai A.; Li, Li and Powers, Hilary J. (2006). Homocysteine from endothelial cells promotes LDL nitration and scavenger receptor uptake. Free Radical Biology and Medicine, 40 (3), pp. 488-500.

Nakano, E.; Taiwo, F.A.; Nugent, D.; Griffiths, Helen R.; Aldred, S.; Paisi, M.; Kwok, M.; Bhatt, P.; Hill, M.H.E; Moat, S. and Powers, H.J. (2005). Downstream effects on human low density lipoprotein of homocysteine exported from endothelial cells in an in vitro system. Journal of Lipid Research, 46 (3), pp. 484-493.

Gherghel, Doina; Griffiths, Helen R.; Hilton, Emma J.; Cunliffe, Ian A. and Hosking, Sarah L. (2005). Systemic reduction in glutathione levels occurs in patients with primary open-angle glaucoma. Investigative Ophthalmology and Visual Science, 46 (3), pp. 877-883.

Phillips, D. C.; Kitas, G. D. and Griffiths, Helen R. (2005). Altered redox signalling processes contribute to T-cell hyporesponsiveness. Free Radical Research, 39 (Suppl.), S17-S17.

Choudhury, Khujesta and Griffiths, Helen R. (2005). Enriching the diet of healthy subjects with almonds - Results from pilot study show reduced VCAM-1 shedding but increased protein oxidation. Free Radical Research, 39 (Suppl.), S53-S53.

Bevan, Ruth J.; Durand, Mireille F.; Griffiths, Helen R. and Lunec, Joseph (2005). Role of glyoxal mediated modifications of low density lipoprotein in diabetic atherosclerosis. Free Radical Research, 39 (Suppl.), S51-S51.

Luan, Y.J. and Griffiths, Helen R. (2005). Short chain ceramide reduces cytosolic peroxides by disrupting NADPH oxidase and inhibiting P47 association with lipid rafts. Free Radical Research, 39 (Suppl.), S67-S67.

Aldred, Sarah and Griffiths, Helen R. (2004). Oxidation of protein in human low-density lipoprotein exposed to peroxyl radicals facilitates uptake by monocytes; protection by antioxidants in vitro. Environmental Toxicology and Pharmacology, 15 (2-3), pp. 111-117.

Bevan, Ruth J.; Durand, Mireille F.; Hickenbotham, Peter T.; Kitas, George D.; Patel, Parul R.; Podmore, Ian D.; Griffiths, Helen R.; Waller, Helen L. and Lunec, Joseph (2003). Validation of a novel ELISA for measurement of MDA-LDL in human plasma. Free Radical Biology and Medicine, 35 (5), pp. 517-527.

Rayment, Sarah J.; Shaw, Jacqui; Woollard, Kevin J.; Lunec, Joe and Griffiths, Helen R. (2003). Vitamin C supplementation in normal subjects reduces constitutive ICAM-1 expression. Biochemical and Biophysical Research Communications, 308 (2), pp. 339-345.

Mistry, Nalini; Podmore, Ian; Cooke, Marcus; Butler, Paul; Griffiths, Helen R.; Herbert, Karl and Lunec, Joseph (2003). Novel monoclonal antibody recognition of oxidative DNA damage adduct, deoxycytidine-glyoxal. Laboratory Investigation, 83 (2), pp. 241-250.

Woollard, Kevin J. and Griffiths, Helen R. (2003). C-Reactive protein signals through the non-receptor tyrosine kinase Syk and induces the expression of TNF-alpha and IL-6 in human monocytes. FASEB Journal, 17 (7), C70-C70.

Barber, Vicki S. and Griffiths, Helen R. (2003). Is glutathione an important neuroprotective effector molecule against amyloid beta toxicity? Biofactors, 17 (1-4), pp. 215-228.

Luan, E.; Phillips, D.C. and Griffiths, Helen R. (2003). Synthetic ceramides inhibit CD36 expression in U937 cells through a reduction in cytosolic peroxide. Free Radical Research, 37 (Suppl.), p. 40.

Woollard, Kevin J.; Phillips, Darren C. and Griffiths, Helen R. (2002). Direct modulatory effect of C-reactive protein on primary human monocyte adhesion to human endothelial cells. Clinical and Experimental Immunology, 130 (2), pp. 256-262.

Lunec, Joseph; Holloway, Karen A.; Cooke, Marcus S.; Faux, Steve; Griffiths, Helen R. and Evans, Mark D. (2002). Urinary 8-oxo-2′-deoxyguanosine:Redox regulation of DNA repair in vivo? Free Radical Biology and Medicine, 33 (7), pp. 875-885.

Griffiths, Helen R.; Olinski, Ryszard; Coolen, Stefan; Collins, Andrew and Astley, Siân B. (2002). Biomarkers. Free Radical Research, 36 (Suppl.), pp. 7-8.

Griffiths, Helen R. (2002). The influence of diet on protein oxidation. Nutrition Research Reviews, 15 (1), pp. 3-17.

Jackson, Malcolm J.; Papa, Sergio; Bolaños, Juan; Bruckdorfer, Richard; Carlsen, Harald; Elliott, Ruan M; Flier, Jacoba; Griffiths, Helen R.; Heales, Simon; Holst, Birgit; Lorusso, Michele; Lund, Elizabeth; Øivind Moskaug, Jan; Moser, Ulrich; Di Paola, Marco; Polidori, M Cristina; Signorile, Anna; Stahl, Wilhelm; Viña-Ribes, José and Astley, Siân B. (2002). Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial function. Molecular Aspects of Medicine, 23 (1-3), pp. 209-285.

Griffiths, Helen R.; Møller, Lennart; Bartosz, Grzegorz; Bast, Aalt; Bertoni-Freddari, Carlo; Collins, Andrew; Cooke, Marcus; Coolen, Stefan; Haenen, Guido; Hoberg, Anne Mette; Loft, Steffen; Lunec, Joe; Olinski, Ryszard; Parry, James; Pompella, Alfonso; Poulsen, Henrik; Verhagen, Hans and Astley, Siân B. (2002). Biomarkers. Molecular Aspects of Medicine, 23 (1-3), pp. 101-208.

Woollard, Kevin J.; Loryman, C.J.; Meredith, E.; Shaw, Jacqui A.; Lunec, Joseph and Griffiths, Helen R. (2002). Effects of dietary vitamin C on monocyte adhesion to endothelial cells in healthy subjects with low plasma ascorbate. Free Radical Research, 36 (Suppl.), pp. 60-61.

Phillips, Darren Charles; Allen, Kirsty and Griffiths, Helen R. (2002). Synthetic ceramides induce growth arrest or apoptosis by altering cellular redox status. Archives of Biochemistry and Biophysics, 407 (1), pp. 15-24.

Griffiths, Helen R. (2000). Antioxidants and protein oxidation. Free Radical Research, 33 (Supple), S47-S58.

Carty, Julie L.; Bevan, Ruth J.; Waller, Helen; Mistry, Nalini; Cooke, Marcus S.; Lunec, Joseph and Griffiths, Helen R. (2000). The effects of vitamin C supplementation on protein oxidation in healthy volunteers. Biochemical and Biophysical Research Communications, 273 (2), pp. 729-735.

Mistry, Nalini; Evans, Mark D.; Griffiths, Helen R.; Kasai, H.; Herbert, Karl E. and Lunec, Joseph (1999). Immunochemical detection of glyoxal DNA damage. Free Radical Biology and Medicine, 26 (9-10), pp. 1267-1273.

Cooke, Marcus S.; Evans, Mark D.; Podmore, Ian D.; Herbert, Karl E.; Mistry, Nalini; Mistry, Pratibha; Hickenbotham, Peter T.; Hussieni, Amina; Griffiths, Helen R. and Lunec, Joseph (1998). Novel repair action of vitamin C upon in vivo oxidative DNA damage. FEBS Letters, 439 (3), pp. 363-367.

Griffiths, Helen R.; Mistry, Pratibha; Herbert, Karl E. and Lunec, Joseph (1998). Molecular and cellular effects of ultraviolet light-induced genotoxicity. Critical Reviews in Clinical Laboratory Sciences, 35 (3), pp. 189-237.

Podmore, Ian D.; Griffiths, Helen R.; Herbert, Karl E.; Mistry, Nalini; Mistry, Pratibha and Lunec, Joseph (1998). Vitamin C exhibits pro-oxidant properties. Nature, 392 (6676), p. 559.

Willets, J.M.; Lambert, D.G.; Lunec, Joseph and Griffiths, Helen R. (1995). Studies on the neurotoxicity of 6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline (salsolinol) in SH-SY5Y cells. European Journal of Pharmacology, 293 (4), pp. 319-326.

Hill, Colin M.; Lunec, Joseph; Griffiths, Helen R. and Herbert, Karl E. (1995). Characterization of tumour necrosis factor alpha release by human granulocytes in response to procainamide challenge. Biochemical Pharmacology, 49 (12), pp. 1837-49.

Willets, J.M.; Lunec, Joseph; Williams, A.C. and Griffiths, Helen R. (1993). Neurotoxicity of nicotinamide derivatives: their role in the aetiology of Parkinson's disease. Biochemical Society Transactions, 21 (pt (3), 299S.

Blount, Susan; Griffiths, Helen R.; Staines, N.A. and Lunec, Joseph (1992). Probing molecular changes induced in DNA by reactive oxygen species with monoclonal antibodies. Immunology Letters, 34 (2), pp. 115-126.

Griffiths, Helen R. and Lunec, Joseph (1991). Effects of reactive oxygen species on immunoglobulin G function. Molecular Aspects of Medicine, 12 (2), pp. 107-119.

Blount, Susan; Griffiths, Helen R. and Lunec, Joseph (1991). Reactive oxygen species damage to DNA and its role in systemic lupus erythematosus. Molecular Aspects of Medicine, 12 (2), pp. 93-105.

Griffiths, Helen R. and Lunec, Joseph (1989). The effects of oxygen free radicals on the carbohydrate moiety of IgG. FEBS Letters, 245 (1-2), pp. 95-99.

Griffiths, Helen R.; Lunec, Joseph; Gee, C.A. and Willson, R.L. (1988). Oxygen radical induced alterations in polyclonal IgG. FEBS Letters, 230 (1-2), pp. 155-158.

Lunec, Joseph; Herbert, Karl E.; Blount, Susan; Griffiths, Helen R. and Emery, Paul 8-Hydroxydeoxyguanosine. A marker of oxidative DNA damage in systemic lupus erythematosus. FEBS Letters, 348 (2), pp. 131-138.

Griffiths, Helen R. and Lunec, Joseph Agalactosylation by reactive oxygen species and Fc related changes to function. Advances in Experimental Medicine and Biology, 376 , pp. 161-170.

Aldred, Sarah; Sozzi, Tommaso; Mudway, Ian; Grant, Melissa M.; Neubert, Hendrik; Kelly, Frank J. and Griffiths, Helen R. Alpha tocopherol supplementation elevates plasma apolipoprotein A1 isoforms in normal healthy subjects. Proteomics, 6 (5), pp. 1695-1703.

Chapple, Iain L.C.; Matthews, John B.; Wright, Helen J.; Scott, Ann E.; Griffiths, Helen R. and Grant, Melissa M. Ascorbate and α-tocopherol differentially modulate reactive oxygen species generation by neutrophils in response to FcγR and TLR agonists. Innate Immunity, 19 (2), pp. 152-159.

Woollard, Kevin J.; Fisch, C.; Newby, R. and Griffiths, Helen R. C-reactive protein mediates CD11b expression in monocytes through the non-receptor tyrosine kinase, Syk, and calcium mobilization but not through cytosolic peroxides. Inflammation Research, 54 (12), pp. 485-492.

Griffiths, Helen R. and Lunec, Joseph The C1q binding activity of IgG is modified in vitro by reactive oxygen species: implications for rheumatoid arthritis. FEBS Letters, 388 (2-3), pp. 161-164.

Bennett, Stuart J.; Augustyniak, Edyta M.; Dunston, Christopher R.; Brown, Richard A.; Shantsila, Eduard; Lip, Gregory Y.H.; Torrão, Rita D.C.; Pararasa, Chathyan; Hussein, Ali R.; Ladouce, Romain; Friguet, Bertrand and Griffiths, Helen R. CD4+ T cell surface alpha enolase is lower in older adults. Mechanisms of Ageing and Development, 152 , 56–62.

Phillips, Darren C. and Griffiths, Helen R. Ceramide induces a loss in cytosolic peroxide levels in mononuclear cells. Biochemical Journal, 375 (Part 3), pp. 567-579.

Lunec, Joseph; Winkles, J.W. and Griffiths, Helen R. Clinical biochemical measurements in rheumatology. Baillière's Clinical Rheumatology, 2 (1), pp. 131-152.

Cooke, Marcus S.; Mistry, Nalini; Ahmad, Jabeen; Waller, Helen; Langford, Lynda; Bevan, Ruth J.; Evans, Mark D.; Jones, George D.D.; Herbert, Karl E.; Griffiths, Helen R. and Lunec, Joseph Deoxycytidine glyoxal:Lesion induction and evidence of repair following vitamin C supplementation in vivo. Free Radical Biology and Medicine, 34 (2), pp. 218-225.

Anlasik, Timur; Sies, Helmut; Griffiths, Helen R.; Mecocci, Patrizia; Stahl, Wilhelm and Polidori, M. Cristina Dietary habits are major determinants of the plasma antioxidant status in healthy elderly subjects. British Journal of Nutrition, 94 (5), pp. 639-642.

Rayment, Sarah J.; Shaw, Jacqui A.; Lunec, Joseph and Griffiths, Helen R. Dietary vitamin C supplementation, but not vitamin E, can modulate transcription of the redox sensitive gene, ICAM-1. Free Radical Research, 36 (Suppl.), pp. 57-58.

Torrão, Rita C.; Bennett, Stuart J.; Brown, James E. and Griffiths, Helen R. Does metabolic reprogramming underpin age-associated changes in T cell phenotype and function? Free Radical Biology and Medicine, 71 , 26–35.

Grant, Melissa M.; Mistry, Nalini; Lunec, Joseph and Griffiths, Helen R. Dose-dependent modulation of the T cell proteome by ascorbic acid. British Journal of Nutrition, 97 (1), pp. 19-26.

Griffiths, Helen R. and Lunec, Joseph Effect of polymorph derived oxidants on IgG in relation to rheumatoid factor binding. Scandinavian Journal of Rheumatology, 17 (s75), pp. 148-156.

Woollard, Kevin J.; Loryman, Chris J.; Meredith, Elizabeth; Bevan, Ruth J.; Shaw, Jacqui A.; Lunec, Joe and Griffiths, Helen R. Effects of oral vitamin C on monocyte:Endothelial cell adhesion in healthy subjects. Biochemical and Biophysical Research Communications, 294 (5), pp. 1161-1168.

Taylor, Simon; Lam, Matthew; Pararasa, Chathyan; Brown, James E.P.; Carmichael, Amtul R. and Griffiths, Helen R. Evaluating the evidence for targeting FOXO3a in breast cancer:a systematic review. Cancer Cell International, 15 (1),

An, E.; Woollard, Kevin; Adams, Eric F. and Griffiths, Helen R. Evaluation of Fc gamma RIIa-H/R polymorphism by allele-specific primer polymerase chain reaction (PCR). FASEB Journal, 17 (7), C106-C106.

Finnegan, M.T.; Herbert, Karl E.; Evans, Mark D.; Griffiths, Helen R. and Lunec, Joseph Evidence for sensitisation of DNA to oxidative damage during isolation. Free Radical Biology and Medicine, 20 (1), pp. 93-98.

Griffiths, Helen R.; Lunec, Joseph; Blake, D.R. and Willson, R.L. Free radical denaturation of immunoglobulin G is due to amino acid oxidation: implications for rheumatoid arthritis. Basic Life Sciences, 49 , pp. 357-360.

Taiwo, F. A.; Powers, H. J.; Nakano, E.; Griffiths, Helen R. and Nugent, D. F. Free radical reactions in atherosclerosis; An EPR spectrometry study. Spectroscopy, 20 (2), pp. 67-80.

Ghattas, Angie; Griffiths, Helen R.; Lip, Gregory and Shantsila, Eduard S. Functional characteristics of monocytes subsets in the acute and healing phases of ST Elevation Myocardial Infarction and their predictive role for major adverse cardiac events. Circulation, 126 (Suppl.),

Dias, Irundika H.K.; Marshall, Lindsay; Lambert, Peter A.; Chapple, Iain L.C.; Matthews, John B. and Griffiths, Helen R. Gingipains from Porphyromonas gingivalis increase the chemotactic and respiratory burst-priming properties of the 77-amino-acid interleukin-8 variant. Infection and Immunity, 76 (1), pp. 317-323.

Li, Li and Griffiths, Helen R. Homocysteine promotes post-translational modifications to HDL in a dose dependent manner. Free Radical Research, 39 (Suppl.), S66-S66.

Dias, Irundika H.K.; Polidori, Maria C. and Griffiths, Helen R. Hypercholesterolaemia-induced oxidative stress at the blood-brain barrier. Biochemical Society Transactions, 42 (4), pp. 1001-1005.

Cooke, Marcus S.; Podmore, Ian D.; Mistry, Nalini; Evans, Mark D.; Herbert, Karl E.; Griffiths, Helen R. and Lunec, Joseph Immunochemical detection of UV-induced DNA damage and repair. Journal of Immunological Methods, 280 (1-2), pp. 125-133.

Mistry, Nalini; Herbert, Karl E.; Evans, Mark D.; Griffiths, Helen R. and Lunec, Joseph Immunochemical detection of reactive oxygen species DNA damage. Biochemical Society Transactions, 23 (3), 482S.

Herbert, Karl E.; Mistry, Nalini; Griffiths, Helen R. and Lunec, Joseph Immunochemical detection of sequence-specific modifications to DNA induced by UV light. Carcinogenesis, 15 (11), pp. 2517-2521.

Russell, Wendy R.; Baka, Athanasia; Björck, Inger; Delzenne, Nathalie; Gao, Dan; Griffiths, Helen R.; Hadjilucas, Ellie; Juvonen, Kristiina; Lahtinen, Sampo; Lansink, Mirian; van Loon, Luc; Mykkänen, Hannu; Riccardi, Gabriele; Östman, Elin; Vinoy, Sophie and Weickert, Martin O. Impact of diet composition on blood glucose regulation. Critical Reviews in Food Science and Nutrition, 56 (4), pp. 541-590.

Griffiths, Helen R.; Willetts, Rachel S.; Grant, Melissa M.; Mistry, Nalini; Lunec, Joseph and Bevan, Ruth J. In vivo vitamin C supplementation increases phosphoinositol transfer protein expression in peripheral blood mononuclear cells from healthy individuals. British Journal of Nutrition, 101 (10), pp. 1432-1439.

Qin, Lu; Bartlett, Hannah E.; Griffiths, Helen R.; Eperjesi, Frank; Armstrong, Richard A. and Gherghel, Doina Macular pigment optical density is related to blood glutathione levels in healthy individuals. Investigative Ophthalmology and Visual Science, 52 (9), pp. 5029-5033.

Grant, M.M.; Griffiths, Helen R. and Lunec, Joseph Modulation of the T-cell proteome by vitamin C. Free Radical Research, 39 (Suppl.), S40-S40.

Dias, Irundika H.K.; Ademowo, Opeyemi S.; Newey, Eloise and Griffiths, Helen R. The Nrf2-ARE activation protect neurones against oxidative stress. Free Radical Biology and Medicine, 86 (Suppl.), S30-S31.

Gao, Dan; Griffiths, Helen R. and Bailey, Clifford J. Oleate protects against palmitate-induced insulin resistance in L6 myotubes. British Journal of Nutrition, 102 (11), pp. 1557-1563.

Li, Li; Willetts, Rachel; Polidori, M. Cristina; Stahl, Wilhelm; Nelles, G.; Sies, Helmut and Griffiths, Helen R. Oxidative LDL modification is increased in vascular dementia and is inversely associated with cognitive performance. Free Radical Research, 44 (3), pp. 241-248.

Griffiths, Helen R.; Wright, J.; Bevan, Ruth J. and Lunec, Joseph Oxidative modification of a specific apolipoprotein B lysine residue confers altered receptor specificity on LDL. Redox report, 4 (6), pp. 337-339.

Lunec, Joseph; Griffiths, Helen R. and Brailsford, S. Oxygen free radicals denature human IgG and increase its reactivity with rheumatoid factor antibody. Scandinavian Journal of Rheumatology, 75 (Supple), pp. 140-7.

Mecocci, Patrizia; Mattioli, Paola; Cecchetti, Roberta; Griffiths, Helen R.; Aldred, Sarah; Stahl, Wilhelm and Polidori, Maria Cristina P4-235 protein oxidation, lipid peroxidation and antioxidant status are similarly altered in Alzheimer disease and vascular dementia. Neurobiology of Aging, 25 (supple), S542-S542.

Dias, Irundika H.K.; Polidori, Maria Cristina; Li, Li; Weber, Daniela; Stahl, Wilhelm; Nelles, Gereon; Grune, Tilman and Griffiths, Helen R. Plasma levels of HDL and carotenoids are lower in dementia patients with vascular comorbidities. Journal of Alzheimer's disease, 40 (2), pp. 399-408.

Griffiths, Helen R. ROS as signalling molecules in T cells - Evidence for abnormal redox signalling in the autoimmune disease, rheumatoid arthritis. Redox report, 10 (6), pp. 273-280.

Blount, S.; Griffiths, Helen R. and Lunec, Joseph Reactive oxygen species induce antigenic changes in DNA. FEBS Letters, 245 (1-2), pp. 100-104.

Cooke, Marcus S.; Evans, Mark D.; Patel, K.; Bogdanov, M.; Mistry, Nalini; Holloway, Karen A.; Griffiths, Helen R.; Bevan, Ruth J.; Durand, Mireille F. and Lunec, Joseph Repair of oxidative DNA damage: benefits of multiple lesion measurement. Free Radical Research, 36 (Suppl.), pp. 42-44.

Lai, M. and Griffiths, Helen R. Role of reactive oxygen species in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. Biochemical Society Transactions, 18 (3), pp. 416-417.

Zong, Geng; Scott, Ann E.; Griffiths, Helen R.; Zock, Peter L.; Dietrich, Thomas and Newson, Rachel S. Serum α-tocopherol has a nonlinear inverse association with periodontitis among US adults. Journal of Nutrition, 145 (5), pp. 893-899.

Willets, J.M.; Lambert, D.G. and Griffiths, Helen R. Suitability of B65 and SH-SY5Y neuroblastoma cells as models for 'in vitro' neurotoxicity testing. Biochemical Society Transactions, 21 (4), 452S.

Griffiths, Helen R.; Bennett, Stuart J.; Olofsson, Peter and Dunston, Christopher R. Thioredoxin as a putative biomarker and candidate target in age-related immune decline. Biochemical Society Transactions, 42 (4), pp. 922-927.

Woollard, Kevin J.; Rayment, Sarah J.; Bevan, Ruth; Shaw, Jacqui A.; Lunec, Joseph and Griffiths, Helen R. α-Tocopherol supplementation does not affect monocyte endothelial adhesion or C-reactive protein levels but reduces soluble vascular adhesion molecule-1 in the plasma of healthy subjects. Redox report, 11 (5), pp. 214-222.

Phillips, Darren C.; Woollard, Kevin J. and Griffiths, Helen R. The anti-inflammatory actions of methotrexate are critically dependent upon the production of reactive oxygen species. British Journal of Pharmacology, 138 (3), pp. 501-511.

Coleman, Michael D.; Zilz, Thomas R.; Griffiths, Helen R. and Woehrling, Elizabeth K. A comparison of the apoptotic and cytotoxic effects of hexanedione derivatives on human non-neuronal lines and the neuroblastoma line SH-SY5Y. Basic and Clinical Pharmacology and Toxicology, 102 (1), pp. 25-29.

Dunston, Christopher and Griffiths, Helen R. The effect of ageing on macrophage Toll-like receptor-mediated responses in the fight against pathogens. Clinical and Experimental Immunology, 161 (3), pp. 407-416.

Rana, Karan S.; Griffiths, Helen R.; Brown, James E.; Navas, Placido and Brown, James The interaction between metabolic disease and ageing. Global Journal of Obesity, Diabetes and Metabolic Syndrome, 1 (1),

Grant, Melissa M.; Barber, Vicki S. and Griffiths, Helen R. The presence of ascorbate induces expression of brain derived neurotrophic factor in SH-SY5Y neuroblastoma cells after peroxide insult, which is associated with increased survival. Proteomics, 5 (2), pp. 534-540.

Griffiths, Helen R.; Dowling, E.J.; Sahinoglu, T.; Blake, D; Parnham, M. and Lunec, Joseph The selective protection afforded by ebselen against lipid peroxidation in an ROS-dependent model of inflammation. Inflammation Research, 36 (1-2), pp. 107-111.

Griffiths, Helen R.; Lunec, Joseph; Jefferis, R.; Blake, D.R. and Willson, R.L. A study of ROS induced denaturation of IgG3 using monoclonal antibodies: implications for inflammatory joint disease. Basic Life Sciences, 49 , pp. 361-364.

Griffiths, Helen R. and Grant, Melissa M. The use of proteomic techniques to explore the holistic effects of nutrients in vivo. Nutrition Research Reviews, 19 (2), pp. 284-293.

Aldred, Sarah; Grant, Melissa M. and Griffiths, Helen R. The use of proteomics for the assessment of clinical samples in research. Clinical Biochemistry, 37 (11), pp. 943-952.

Book Section

Killick, Justin W.; Bennett, Stuart J.; Dias, Irundika H.K.; Dunston, Christopher R. and Griffiths, Helen R. (2014). A role for epigenetic modulation of the innate immune response during aging. IN: Immunology of aging. Massoud, Ahmad and Rezaei, Nima (eds) Berlin (DE): Springer.

Conference or Workshop Item

Meredith, Stuart P.; Parekh, Gita; Schouten, James; Wilkins, John; Griffiths, Helen R.; Davis, Paul and Spickett, Corinne M. (2016). Generation of antibodies with varying sequence specifity for Oxidatively-modified peptides from human fibrinogen. IN: UNSPECIFIED. .

Dias, Irundika H.k.; Milic, Ivana; Devitt, Andrew; Spickett, Corinne M.; Pitt, Andrew R. and Griffiths, Helen R. (2016). Mass spectrometry based method for measurement of oxysterols. IN: UNSPECIFIED. .

Choudhury, Khujesta and Griffiths, Helen R. (2007). Dietary enrichment with almond (Prunus amygdalis) supplementation: effects on CVD risk biomarkers. IN: Scientific Meeting of the Nutrition Society. 2007-07-01. (Unpublished)

Gao, Dan; Griffiths, Helen R. and Bailey, Clifford J. (2007). Palmitate induces insulin resistance in monocytes and increases expression of the integrin CD11b. IN: Scientific Meeting of the Nutrition Society. 2007-07-01. (Unpublished)

Grant, M. and Griffiths, Helen R. (2003). Detection of carbonylation and 3-nitrotyrosine as protein oxidation biomarkers. IN: Society of Toxicology Annual Conference. 2003-01-01 - 2003-01-01. (Unpublished)

Griffiths, Helen R.; Rayment, Sarah; Shaw, Jaqui; Lunec, Joe and Woollard, Kevin (2003). Dietary supplementation with vitamin C but not vitamin E reduces constitutive expression of ICAM-1 in peripheral blood monocytes of normal subjects with low plasma vitamin C levels. IN: SFRBM's 10th Annual Meeting. 2003-11-01. (Unpublished)

Grant, Melissa; Powers, Hilary; Moat, Stuart; McDowell, Ian and Griffiths, Helen R. (2003). Folate supplementation and methylene tetrahydrofolate reductase genotype neither quantitatively nor qualitatively modulates plasma protein oxidation. IN: SFRBM's 10th Annual Meeting. 2003-11-01. (Unpublished)

Griffiths, Helen R. and Woollard, Kevin C-reactive protein mediates CD11B expression in monocytes through the non-receptor tyrosine kinase, Syk, and not through cytosolic peroxides. IN: SFRBM's 10th Annual Meeting. 2003-11-01.

Phillips, Darren and Griffiths, Helen R. Mononuclear cell responses of apoptosis in T cells and growth arrest in monocytes to synthetic ceramide are mediated by loss of cytosolic peroxide. IN: SFRBM's 10th Annual Meeting. 2003-11-01.