Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial function

Jackson, Malcolm J., Papa, Sergio, Bolaños, Juan, Bruckdorfer, Richard, Carlsen, Harald, Elliott, Ruan M, Flier, Jacoba, Griffiths, Helen R., Heales, Simon, Holst, Birgit, Lorusso, Michele, Lund, Elizabeth, Øivind Moskaug, Jan, Moser, Ulrich, Di Paola, Marco, Polidori, M Cristina, Signorile, Anna, Stahl, Wilhelm, Viña-Ribes, José and Astley, Siân B. (2002). Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial function. Molecular Aspects of Medicine, 23 (1-3), pp. 209-285.


Redox-sensitive cell signalling Thiol groups and the regulation of gene expression Redox-sensitive signal transduction pathways Protein kinases Protein phosphatases Lipids and phospholipases Antioxidant (electrophile) response element Intracellular calcium signalling Transcription factors NF-?B AP-1 p53 Cellular responses to oxidative stress Cellular responses to change in redox state Proliferation Cell death Immune cell function Reactive oxygen and nitrogen species – good or bad? Reactive oxygen species and cell death Reactive oxygen species and inflammation Are specific reactive oxygen species and antioxidants involved in modulating cellular responses? Specific effects of dietary antioxidants in cell regulation Carotenoids Vitamin E Flavonoids Inducers of phase II enzymes Disease states affected Oxidants, antioxidants and mitochondria Introduction Mitochondrial generation of reactive oxygen and nitrogen species Mitochondria and apoptosis Mitochondria and antioxidant defences Key role of mitochondrial GSH in the defence against oxidative damage Mitochondrial oxidative damage Direct oxidative damage to the mitochondrial electron transport chain Nitric oxide and damage to mitochondria Effects of nutrients on mitochondria Caloric restriction and antioxidants Lipids Antioxidants Techniques and approaches Mitochondrial techniques cDNA microarray approaches Proteomics approaches Transgenic mice as tools in antioxidant research Gene knockout and over expression Transgenic reporter mice Conclusions Future research needs

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Divisions: Life & Health Sciences
Uncontrolled Keywords: Biochemistry,Molecular Biology,Molecular Medicine
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Published Date: 2002-02
Authors: Jackson, Malcolm J.
Papa, Sergio
Bolaños, Juan
Bruckdorfer, Richard
Carlsen, Harald
Elliott, Ruan M
Flier, Jacoba
Griffiths, Helen R. ( 0000-0002-2666-2147)
Heales, Simon
Holst, Birgit
Lorusso, Michele
Lund, Elizabeth
Øivind Moskaug, Jan
Moser, Ulrich
Di Paola, Marco
Polidori, M Cristina
Signorile, Anna
Stahl, Wilhelm
Viña-Ribes, José
Astley, Siân B.


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