MARK-AGE biomarkers of ageing

Abstract

Many candidate biomarkers of human ageing have been proposed in the scientific literature but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has proven to serve a useful marker to determine, on its own, biological age. A plausible reason for this is the intrinsic multi-causal and multi-system nature of the ageing process. The recently completed MARK-AGE study was a large-scale integrated project supported by the European Commission. The major aim of this project was to conduct a population study comprising about 3200 subjects in order to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation.

Publication DOI: https://doi.org/10.1016/j.mad.2015.03.006
Divisions: ?? 98525700JI ??
Life & Health Sciences > Applied Health Research Group
Life & Health Sciences
Life & Health Sciences > Biomedical Sciences research group
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Additional Information: © 2015 Z. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). European Commission for financial support through the FP7 large-scale integrating project “European Study to Establish Biomarkers of Human Ageing” (MARK-AGE; grant agreement no.: 200880.
Uncontrolled Keywords: ageing biomarkers,human studies,MARK-AGE,Ageing,Developmental Biology
Published Date: 2015-11

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