Plasma levels of HDL and carotenoids are lower in dementia patients with vascular comorbidities

Abstract

Elevated serum cholesterol concentrations in mid-life increase risk for Alzheimer's disease (AD) in later life. However, lower concentrations of cholesterol-carrying high density lipoprotein (HDL) and its principal apolipoprotein A1 (ApoA1) correlate with increased risk for AD. As HDL transports oxocarotenoids, which are scavengers of peroxynitrite, we have investigated the hypothesis that lower HDL and oxocarotenoid concentrations during AD may render HDL susceptible to nitration and oxidation and in turn reduce the efficiency of reverse cholesterol transport (RCT) from lipid-laden cells. Fasting blood samples were obtained from subjects with 1) AD without cardiovascular comorbidities and risk factors (AD); 2) AD with cardiovascular comorbidities and risk factors (AD Plus); 3) normal cognitive function; for carotenoid determination by HPLC, analysis of HDL nitration and oxidation by ELISA, and 3H-cholesterol export to isolated HDL. HDL concentration in the plasma from AD Plus patients was significantly lower compared to AD or control subject HDL levels. Similarly, lutein, lycopene, and zeaxanthin concentrations were significantly lower in AD Plus patients compared to those in control subjects or AD patients, and oxocarotenoid concentrations correlated with Mini-Mental State Examination scores. At equivalent concentrations of ApoA1, HDL isolated from all subjects irrespective of diagnosis was equally effective at mediating RCT. HDL concentration is lower in AD Plus patients' plasma and thus capacity for RCT is compromised. In contrast, HDL from patients with AD-only was not different in concentration, modifications, or function from HDL of healthy age-matched donors. The relative importance of elevating HDL alone compared with elevating carotenoids alone or elevating both to reduce risk for dementia should be investigated in patients with early signs of dementia.

Publication DOI: https://doi.org/10.3233/JAD-131964
Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences
College of Health & Life Sciences > Chronic and Communicable Conditions
College of Health & Life Sciences > School of Biosciences > Cell & Tissue Biomedical Research
Additional Information: This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License.
Uncontrolled Keywords: 3-nitrotyrosine,aging,alzheimer's disease,free radical scavenger,protein carbonyl formation,protein oxidation,Psychiatry and Mental health,Geriatrics and Gerontology,Clinical Psychology,Medicine(all)
Publication ISSN: 1875-8908
Last Modified: 15 Feb 2024 08:17
Date Deposited: 26 Feb 2015 09:20
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
http://iospress ... -2877&volume=40 (Publisher URL)
PURE Output Type: Article
Published Date: 2014-03-31
Published Online Date: 2014-01-21
Authors: Dias, Irundika H.K. (ORCID Profile 0000-0002-6620-8221)
Polidori, Maria Cristina
Li, Li
Weber, Daniela
Stahl, Wilhelm
Nelles, Gereon
Grune, Tilman
Griffiths, Helen R. (ORCID Profile 0000-0002-2666-2147)

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