Browse by Aston Author

2016

Meredith, Stuart P.; Parekh, Gita; Schouten, James; Wilkins, John; Griffiths, Helen R.; Davis, Paul and Spickett, Corinne M. (2016). Generation of antibodies with varying sequence specifity for Oxidatively-modified peptides from human fibrinogen. IN: UNSPECIFIED. .

Dias, Irundika H.k.; Milic, Ivana; Devitt, Andrew; Spickett, Corinne M.; Pitt, Andrew R. and Griffiths, Helen R. (2016). Mass spectrometry based method for measurement of oxysterols. IN: UNSPECIFIED. .

Pararasa, Chathyan; Ikwuobe, John; Shigdar, Shahjahan; Boukouvalas, Alexis; Nabney, Ian T.; Brown, James E.; Devitt, Andrew; Bailey, Clifford J.; Bennett, Stuart J. and Griffiths, Helen R. (2016). Age-associated changes in long-chain fatty acid profile during healthy aging promote pro-inflammatory monocyte polarization via PPARγ. Aging Cell, 15 (1), pp. 128-139.

2015

Dias, Irundika H.K.; Brown, Caroline L.R.; Polidori-Nelles, Maria Cristina; Lip, Gregory Y.H. and Griffiths, Helen R. (2015). LDL-Lipids from patients with hypercholesterolaemia and Alzheimer's disease are inflammatory to microvascular endothelial cells:mitigation by statin intervention. Clinical Science, 129 (12), pp. 1195-1206.

Bürkle, Alexander; Moreno-Villanueva, María; Bernhard, Jürgen; Blasco, María; Zondag, Gerben; Hoeijmakers, Jan H.J.; Toussaint, Olivier; Grubeck-Loebenstein, Beatrix; Mocchegiani, Eugenio; Collino, Sebastiano; Gonos, Efstathios S.; Sikora, Ewa; Gradinaru, Daniela; Dollé, Martijn; Salmon, Michel; Kristensen, Peter; Griffiths, Helen R.; Libert, Claude; Grune, Tilman; Breusing, Nicolle; Simm, Andreas; Franceschi, Claudio; Capri, Miriam; Talbot, Duncan; Caiafa, Paola; Friguet, Bertrand; Slagboom, P. Eline; Hervonen, Antti; Hurme, Mikko and Aspinall, Richard (2015). MARK-AGE biomarkers of ageing. Mechanisms of Ageing and Development, 151 , pp. 2-12.

McBean, Gethin J.; Aslan, Mutay; Griffiths, Helen R. and Torrão, Rita C (2015). Thiol redox homeostasis in neurodegenerative disease. Redox biology, 5 , pp. 186-194.

Perrie, Yvonne; Griffiths, Helen R. and Jones, David (2015). Enhancing vaccine design strategies:applications for protein science, proteomics and adjuvants. Journal of Pharmacy and Pharmacology, 67 (3), pp. 287-289.

Ruskovska, Tatjana; Bennett, Stuart J.; Brown, Caroline R.; Dimitrov, Slave; Kamcev, Nikola and Griffiths, Helen R. (2015). Ankyrin is the major oxidised protein in erythrocyte membranes from end-stage renal disease patients on chronic haemodialysis and oxidation is decreased by dialysis and vitamin C supplementation. Free Radical Research, 49 (2), pp. 175-185.

Pararasa, Chathyan; Bailey, Clifford J. and Griffiths, Helen R. (2015). Ageing, adipose tissue, fatty acids and inflammation. Biogerontology, 16 (2), pp. 235-248.

Marshall, Lindsay J.; Oguejiofor, Wilson; Willetts, Rachel S.; Griffiths, Helen R. and Devitt, Andrew (2015). Developing accurate models of the human airways. Journal of Pharmacy and Pharmacology, 67 (3), pp. 464-472.

Dunston, Christopher R.; Herbert, Rebecca and Griffiths, Helen R. (2015). Improving T cell-induced response to subunit vaccines:opportunities for a proteomic systems approach. Journal of Pharmacy and Pharmacology, 67 (3), pp. 290-299.

2014

Griffiths, Helen R. and Lip, Gregory Y.H. (2014). New biomarkers and risk stratification in atrial fibrillation:simplicity and practicality matter. Circulation, 130 (21), pp. 1837-1839.

Killick, Justin W.; Bennett, Stuart J.; Dias, Irundika H.K.; Dunston, Christopher R. and Griffiths, Helen R. (2014). A role for epigenetic modulation of the innate immune response during aging. IN: Immunology of aging. Massoud, Ahmad and Rezaei, Nima (eds) Berlin (DE): Springer.

Dias, Irundika H.K.; Mistry, Jayna; Fell, Shaun; Reis, Ana; Spickett, Corinne M.; Polidori, Maria C; Lip, Greg Y.H. and Griffiths, Helen R. (2014). Oxidised LDL-lipids increase beta amyloid production by SH-SY5Y cells through glutathione depletion and lipid raft formation. Free Radical Biology and Medicine, 75 , 48–59.

Dias, Irundika H.K. and Griffiths, Helen R. (2014). Oxidative stress in diabetes - circulating advanced glycation end products, lipid oxidation and vascular disease. Annals of Clinical Biochemistry, 51 (2), pp. 125-127.

Griffiths, Helen R.; Dias, Irundika; Willetts, Rachel S. and Devitt, Andrew (2014). Redox regulation of protein damage in plasma. Redox biology, 2 (1), pp. 430-435.

2013

Ratnayake, Shibani; Dias, Irundika H.K.; Lattmann, Eric and Griffiths, Helen R. (2013). Stabilising cysteinyl thiol oxidation and nitrosation for proteomic analysis. Journal of Proteomics, 92 , pp. 160-170.

Ghattas, Angie; Griffiths, Helen R.; Devitt, Andrew; Lip, Gregory Y.H. and Shantsila, Eduard (2013). Monocytes in coronary artery disease and atherosclerosis:where are we now? Journal of the American College of Cardiology, 62 (17), pp. 1541-1551.

Turner, James E.; Bennett, Stuart J.; Campbell, John P.; Bosch, Jos A.; Aldred, Sarah and Griffiths, Helen R. (2013). The antioxidant enzyme peroxiredoxin-2 is depleted in lymphocytes seven days after ultra-endurance exercise. Free Radical Research, 47 (10), pp. 821-828.

Dias, Irundika H.K.; Chapple, Ian L.C.; Milward, Mike; Grant, Melissa M.; Hill, Eric; Brown, James and Griffiths, Helen R. (2013). Sulforaphane restores cellular glutathione levels and reduces chronic periodontitis neutrophil hyperactivity in vitro. PLoS ONE, 8 (6),

Weber, Daniela; Milkovic, Lidija; Bennett, Stuart J.; Griffiths, Helen R.; Zarkovic, Neven and Grune, Tilman (2013). Measurement of HNE-protein adducts in human plasma and serum by ELISA-Comparison of two primary antibodies. Redox biology, 1 (1), pp. 226-233.

Kolamunne, Rajitha T.; Dias, Irundika H.K.; Vernallis, Ann B.; Grant, Melissa M. and Griffiths, Helen R. (2013). Nrf2 activation supports cell survival during hypoxia and hypoxia/reoxygenation in cardiomyoblasts; the roles of reactive oxygen and nitrogen species. Redox biology, 1 (1), pp. 418-426.

2012

Dunston, Christopher R.; Choudhury, Khujesta and Griffiths, Helen R. (2012). Terminal galactose residues on transferrin are increased in mid-life adults compared to young adults. Proteomics, 12 (21), pp. 3147-3153.

Ghattas, Angie; Lip, Gregory Y.H.; Griffiths, Helen R. and Shantsila, Eduard S. (2012). Functional characteristics of monocytes subsets in the acute and healing phases of ST elevation myocardial infarction and their effect on ejection fraction. European Heart Journal, 33 (Suppl.), p. 787.

Ghattas, Angie; Lip, Gregory Y.H.; Griffiths, Helen R. and Shantsila, Eduard S. (2012). Predictive role of specific monocyte subsets for major adverse cardiac events after ST-elevation myocardial infarction. European Heart Journal, 33 (Suppl.), pp. 919-920.

Gao, Dan; Pararasa, Chathyan; Dunston, Christopher R; Bailey, Clifford J. and Griffiths, Helen R. (2012). Palmitate promotes monocyte atherogenicity via de novo ceramide synthesis. Free Radical Biology and Medicine, 53 (4), 796–806.

2011

Akbar, Sarah; Bellary, Srikanth and Griffiths, Helen R. (2011). Dietary antioxidant interventions in type 2 diabetes patients:a meta-analysis. British Journal of Diabetes and Vascular Disease, 11 (2), pp. 62-68.

2010

Polidori, M. Cristina; Pientka, Ludger; Nelles, Gereon and Griffiths, Helen R. (2010). Modulation of cholesterol in midlife affords cognitive advantage during ageing - a role for altered redox balance. International Journal of Clinical and Experimental Medicine, 3 (2), pp. 103-109.

2009

Gao, Dan; Bailey, Clifford J. and Griffiths, Helen R. (2009). Metabolic memory effect of the saturated fatty acid, palmitate, in monocytes. Biochemical and Biophysical Research Communications, 388 (2), pp. 278-282.

2008

Griffiths, Helen R. (2008). Is the generation of neo-antigenic determinants by free radicals central to the development of autoimmune rheumatoid disease? Autoimmunity Reviews, 7 (7), pp. 544-549.

Griffiths, Helen R.; Grune, Tilman; Gonos, Efstathios and Kartal-Ozer, Nesrin (2008). Report of Society for Free Radical Research Europe Summer School. Biofactors, 33 (2), pp. 157-160.

2007

Grant, Melissa M.; Scheel-Toellner, D. and Griffiths, Helen R. (2007). Contributions to our understanding of T cell physiology through unveiling the T cell proteome. Clinical and Experimental Immunology, 149 (1), pp. 9-15.

Choudhury, Khujesta and Griffiths, Helen R. (2007). Dietary enrichment with almond (Prunus amygdalis) supplementation: effects on CVD risk biomarkers. IN: Scientific Meeting of the Nutrition Society. 2007-07-01. (Unpublished)

Gao, Dan; Griffiths, Helen R. and Bailey, Clifford J. (2007). Palmitate induces insulin resistance in monocytes and increases expression of the integrin CD11b. IN: Scientific Meeting of the Nutrition Society. 2007-07-01. (Unpublished)

Grant, Melissa M. and Griffiths, Helen R. (2007). Cell passage-associated transient high oxygenation causes a transient decrease in cellular glutathione and affects T cell responses to apoptotic and mitogenic stimuli. Environmental Toxicology and Pharmacology, 23 (3), pp. 335-339.

Polidori, M. Cristina; Griffiths, Helen R.; Mariani, E. and Mecocci, Patrizia (2007). Hallmarks of protein oxidative damage in neurodegenerative diseases:Focus on Alzheimer's disease. Amino Acids, 32 (4), pp. 553-559.

Zilz, Thomas R.; Griffiths, Helen R. and Coleman, Michael D. (2007). Apoptotic and necrotic effects of hexanedione derivatives on the human neuroblastoma line SK-N-SH. Toxicology, 231 (2-3), pp. 210-214.

Choudhury, Khujesta and Griffiths, Helen R. (2007). Dietary enrichment with almonds reduces oxidative stress and improves vascular function. Free Radical Research, 41 (s1), S21-S21.

2006

Luan, Yingjun and Griffiths, Helen R. (2006). Ceramides reduce CD36 cell surface expression and oxidised LDL uptake by monocytes and macrophages. Archives of Biochemistry and Biophysics, 450 (1), pp. 89-99.

Williamson, Matthew R.; Woollard, Kevin J.; Griffiths, Helen R. and Coombes, Allan G.A. (2006). Gravity spun polycaprolactone fibers for applications in vascular tissue engineering:proliferation and function of human vascular endothelial cells. Tissue Engineering, 12 (1), pp. 45-51.

Griffiths, Helen R.; Aldred, Sarah; Dale, Chloe; Nakano, Emi; Kitas, George D.; Grant, Melissa G.; Nugent, Desmond; Taiwo, Fatai A.; Li, Li and Powers, Hilary J. (2006). Homocysteine from endothelial cells promotes LDL nitration and scavenger receptor uptake. Free Radical Biology and Medicine, 40 (3), pp. 488-500.

2005

Nakano, E.; Taiwo, F.A.; Nugent, D.; Griffiths, Helen R.; Aldred, S.; Paisi, M.; Kwok, M.; Bhatt, P.; Hill, M.H.E; Moat, S. and Powers, H.J. (2005). Downstream effects on human low density lipoprotein of homocysteine exported from endothelial cells in an in vitro system. Journal of Lipid Research, 46 (3), pp. 484-493.

Gherghel, Doina; Griffiths, Helen R.; Hilton, Emma J.; Cunliffe, Ian A. and Hosking, Sarah L. (2005). Systemic reduction in glutathione levels occurs in patients with primary open-angle glaucoma. Investigative Ophthalmology and Visual Science, 46 (3), pp. 877-883.

Phillips, D. C.; Kitas, G. D. and Griffiths, Helen R. (2005). Altered redox signalling processes contribute to T-cell hyporesponsiveness. Free Radical Research, 39 (Suppl.), S17-S17.

Choudhury, Khujesta and Griffiths, Helen R. (2005). Enriching the diet of healthy subjects with almonds - Results from pilot study show reduced VCAM-1 shedding but increased protein oxidation. Free Radical Research, 39 (Suppl.), S53-S53.

Bevan, Ruth J.; Durand, Mireille F.; Griffiths, Helen R. and Lunec, Joseph (2005). Role of glyoxal mediated modifications of low density lipoprotein in diabetic atherosclerosis. Free Radical Research, 39 (Suppl.), S51-S51.

Luan, Y.J. and Griffiths, Helen R. (2005). Short chain ceramide reduces cytosolic peroxides by disrupting NADPH oxidase and inhibiting P47 association with lipid rafts. Free Radical Research, 39 (Suppl.), S67-S67.

2004

Aldred, Sarah and Griffiths, Helen R. (2004). Oxidation of protein in human low-density lipoprotein exposed to peroxyl radicals facilitates uptake by monocytes; protection by antioxidants in vitro. Environmental Toxicology and Pharmacology, 15 (2-3), pp. 111-117.

2003

Bevan, Ruth J.; Durand, Mireille F.; Hickenbotham, Peter T.; Kitas, George D.; Patel, Parul R.; Podmore, Ian D.; Griffiths, Helen R.; Waller, Helen L. and Lunec, Joseph (2003). Validation of a novel ELISA for measurement of MDA-LDL in human plasma. Free Radical Biology and Medicine, 35 (5), pp. 517-527.

Rayment, Sarah J.; Shaw, Jacqui; Woollard, Kevin J.; Lunec, Joe and Griffiths, Helen R. (2003). Vitamin C supplementation in normal subjects reduces constitutive ICAM-1 expression. Biochemical and Biophysical Research Communications, 308 (2), pp. 339-345.

Mistry, Nalini; Podmore, Ian; Cooke, Marcus; Butler, Paul; Griffiths, Helen R.; Herbert, Karl and Lunec, Joseph (2003). Novel monoclonal antibody recognition of oxidative DNA damage adduct, deoxycytidine-glyoxal. Laboratory Investigation, 83 (2), pp. 241-250.

Woollard, Kevin J. and Griffiths, Helen R. (2003). C-Reactive protein signals through the non-receptor tyrosine kinase Syk and induces the expression of TNF-alpha and IL-6 in human monocytes. FASEB Journal, 17 (7), C70-C70.

Grant, M. and Griffiths, Helen R. (2003). Detection of carbonylation and 3-nitrotyrosine as protein oxidation biomarkers. IN: Society of Toxicology Annual Conference. 2003-01-01 - 2003-01-01. (Unpublished)

Griffiths, Helen R.; Rayment, Sarah; Shaw, Jaqui; Lunec, Joe and Woollard, Kevin (2003). Dietary supplementation with vitamin C but not vitamin E reduces constitutive expression of ICAM-1 in peripheral blood monocytes of normal subjects with low plasma vitamin C levels. IN: SFRBM's 10th Annual Meeting. 2003-11-01. (Unpublished)

Grant, Melissa; Powers, Hilary; Moat, Stuart; McDowell, Ian and Griffiths, Helen R. (2003). Folate supplementation and methylene tetrahydrofolate reductase genotype neither quantitatively nor qualitatively modulates plasma protein oxidation. IN: SFRBM's 10th Annual Meeting. 2003-11-01. (Unpublished)

Barber, Vicki S. and Griffiths, Helen R. (2003). Is glutathione an important neuroprotective effector molecule against amyloid beta toxicity? Biofactors, 17 (1-4), pp. 215-228.

Luan, E.; Phillips, D.C. and Griffiths, Helen R. (2003). Synthetic ceramides inhibit CD36 expression in U937 cells through a reduction in cytosolic peroxide. Free Radical Research, 37 (Suppl.), p. 40.

2002

Woollard, Kevin J.; Phillips, Darren C. and Griffiths, Helen R. (2002). Direct modulatory effect of C-reactive protein on primary human monocyte adhesion to human endothelial cells. Clinical and Experimental Immunology, 130 (2), pp. 256-262.

Lunec, Joseph; Holloway, Karen A.; Cooke, Marcus S.; Faux, Steve; Griffiths, Helen R. and Evans, Mark D. (2002). Urinary 8-oxo-2′-deoxyguanosine:Redox regulation of DNA repair in vivo? Free Radical Biology and Medicine, 33 (7), pp. 875-885.

Griffiths, Helen R.; Olinski, Ryszard; Coolen, Stefan; Collins, Andrew and Astley, Siân B. (2002). Biomarkers. Free Radical Research, 36 (Suppl.), pp. 7-8.

Griffiths, Helen R. (2002). The influence of diet on protein oxidation. Nutrition Research Reviews, 15 (1), pp. 3-17.

Jackson, Malcolm J.; Papa, Sergio; Bolaños, Juan; Bruckdorfer, Richard; Carlsen, Harald; Elliott, Ruan M; Flier, Jacoba; Griffiths, Helen R.; Heales, Simon; Holst, Birgit; Lorusso, Michele; Lund, Elizabeth; Øivind Moskaug, Jan; Moser, Ulrich; Di Paola, Marco; Polidori, M Cristina; Signorile, Anna; Stahl, Wilhelm; Viña-Ribes, José and Astley, Siân B. (2002). Antioxidants, reactive oxygen and nitrogen species, gene induction and mitochondrial function. Molecular Aspects of Medicine, 23 (1-3), pp. 209-285.

Griffiths, Helen R.; Møller, Lennart; Bartosz, Grzegorz; Bast, Aalt; Bertoni-Freddari, Carlo; Collins, Andrew; Cooke, Marcus; Coolen, Stefan; Haenen, Guido; Hoberg, Anne Mette; Loft, Steffen; Lunec, Joe; Olinski, Ryszard; Parry, James; Pompella, Alfonso; Poulsen, Henrik; Verhagen, Hans and Astley, Siân B. (2002). Biomarkers. Molecular Aspects of Medicine, 23 (1-3), pp. 101-208.

Woollard, Kevin J.; Loryman, C.J.; Meredith, E.; Shaw, Jacqui A.; Lunec, Joseph and Griffiths, Helen R. (2002). Effects of dietary vitamin C on monocyte adhesion to endothelial cells in healthy subjects with low plasma ascorbate. Free Radical Research, 36 (Suppl.), pp. 60-61.

Phillips, Darren Charles; Allen, Kirsty and Griffiths, Helen R. (2002). Synthetic ceramides induce growth arrest or apoptosis by altering cellular redox status. Archives of Biochemistry and Biophysics, 407 (1), pp. 15-24.

2000

Griffiths, Helen R. (2000). Antioxidants and protein oxidation. Free Radical Research, 33 (Supple), S47-S58.

Carty, Julie L.; Bevan, Ruth J.; Waller, Helen; Mistry, Nalini; Cooke, Marcus S.; Lunec, Joseph and Griffiths, Helen R. (2000). The effects of vitamin C supplementation on protein oxidation in healthy volunteers. Biochemical and Biophysical Research Communications, 273 (2), pp. 729-735.

1999

Mistry, Nalini; Evans, Mark D.; Griffiths, Helen R.; Kasai, H.; Herbert, Karl E. and Lunec, Joseph (1999). Immunochemical detection of glyoxal DNA damage. Free Radical Biology and Medicine, 26 (9-10), pp. 1267-1273.

1998

Cooke, Marcus S.; Evans, Mark D.; Podmore, Ian D.; Herbert, Karl E.; Mistry, Nalini; Mistry, Pratibha; Hickenbotham, Peter T.; Hussieni, Amina; Griffiths, Helen R. and Lunec, Joseph (1998). Novel repair action of vitamin C upon in vivo oxidative DNA damage. FEBS Letters, 439 (3), pp. 363-367.

Griffiths, Helen R.; Mistry, Pratibha; Herbert, Karl E. and Lunec, Joseph (1998). Molecular and cellular effects of ultraviolet light-induced genotoxicity. Critical Reviews in Clinical Laboratory Sciences, 35 (3), pp. 189-237.

Podmore, Ian D.; Griffiths, Helen R.; Herbert, Karl E.; Mistry, Nalini; Mistry, Pratibha and Lunec, Joseph (1998). Vitamin C exhibits pro-oxidant properties. Nature, 392 (6676), p. 559.

1995

Willets, J.M.; Lambert, D.G.; Lunec, Joseph and Griffiths, Helen R. (1995). Studies on the neurotoxicity of 6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline (salsolinol) in SH-SY5Y cells. European Journal of Pharmacology, 293 (4), pp. 319-326.

Hill, Colin M.; Lunec, Joseph; Griffiths, Helen R. and Herbert, Karl E. (1995). Characterization of tumour necrosis factor alpha release by human granulocytes in response to procainamide challenge. Biochemical Pharmacology, 49 (12), pp. 1837-49.

1993

Willets, J.M.; Lunec, Joseph; Williams, A.C. and Griffiths, Helen R. (1993). Neurotoxicity of nicotinamide derivatives: their role in the aetiology of Parkinson's disease. Biochemical Society Transactions, 21 (pt (3), 299S.

1992

Blount, Susan; Griffiths, Helen R.; Staines, N.A. and Lunec, Joseph (1992). Probing molecular changes induced in DNA by reactive oxygen species with monoclonal antibodies. Immunology Letters, 34 (2), pp. 115-126.

1991

Griffiths, Helen R. and Lunec, Joseph (1991). Effects of reactive oxygen species on immunoglobulin G function. Molecular Aspects of Medicine, 12 (2), pp. 107-119.

Blount, Susan; Griffiths, Helen R. and Lunec, Joseph (1991). Reactive oxygen species damage to DNA and its role in systemic lupus erythematosus. Molecular Aspects of Medicine, 12 (2), pp. 93-105.

1989

Griffiths, Helen R. and Lunec, Joseph (1989). The effects of oxygen free radicals on the carbohydrate moiety of IgG. FEBS Letters, 245 (1-2), pp. 95-99.

1988

Griffiths, Helen R.; Lunec, Joseph; Gee, C.A. and Willson, R.L. (1988). Oxygen radical induced alterations in polyclonal IgG. FEBS Letters, 230 (1-2), pp. 155-158.