Browse by Aston Author

Coudrat, Thomas; Simms, John; Christopoulos, Arthur; Wootten, Denise and Sexton, Patrick M. (2017). Improving virtual screening of G protein-coupled receptors via ligand-directed modeling. PLoS computational biology, 13 (11), e1005819.

Woolley, Michael J.; Simms, John; Uddin, Sifat; Poyner, David R. and Conner, Alex C. (2017). Relative antagonism of mutants of the CGRP receptor extracellular loop 2 domain (ECL2) using a truncated competitive antagonist (CGRP8-37):evidence for the dual involvement of ECL2 in the two-domain binding model. Biochemistry, 56 (30), pp. 3877-3880.

Wootten, Denise; Reynolds, Christopher A.; Smith, Kevin J.; Mobarec, Juan C.; Koole, Cassandra; Savage, Emilia E.; Pabreja, Kavita; Simms, John; Sridhar, Rohan; Furness, Sebastian G.B.; Liu, Mengjie; Thompson, Philip E.; Miller, Laurence J.; Christopoulos, Arthur and Sexton, Patrick M. (2016). The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonism. Cell, 165 (7), pp. 1632-1643.

Wootten, Denise; Reynolds, Christopher A.; Koole, Cassandra; Smith, Kevin J.; Mobarec, Juan C.; Simms, John; Quon, Tezz; Coudrat, Thomas; Furness, Sebastian G.B.; Miller, Laurence J.; Christopoulos, Arthur and Sexton, Patrick M. (2016). A hydrogen-bonded polar network in the core of the glucagon-like peptide-1 receptor is a fulcrum for biased agonism:lessons from class B crystal structuress. Molecular Pharmacology, 89 (3), pp. 335-347.

Barwell, James; Wootten, Denise; Simms, John; Hay, Debbie L. and Poyner, David R. (2012). RAMPs and CGRP receptors. Advances in Experimental Medicine and Biology, 744 , pp. 13-24.

Qi, Tao; Simms, John; Bailey, Richard J.; Wheatley, Mark; L. Rathbone, Daniel; Hay, Debbie L. and Poyner, David R (2010). Structure-function analysis of RAMP1-RAMP3 chimeras. Biochemistry, 49 (3), pp. 522-531.

Conner, Alex C.; Simms, John; Conner, Matthew T.; Wootten, Denise L.; Wheatley, Mark and Poyner, David R. (2006). Diverse functional motifs within the three intracellular loops of the CGRP1 receptor. Biochemistry, 45 (43), pp. 12976-12985.

Simms, John; Hay, Debbie L.; Wheatley, Mark and Poyner, David R. (2006). Characterization of the structure of RAMP1 by mutagenesis and molecular modeling. Biophysical Journal, 91 (2), pp. 662-669.

Conner, Alex C.; Simms, John; Howitt, Stephen G.; Wheatley, Mark and Poyner, David R. (2006). The second intracellular loop of the calcitonin gene-related peptide receptor provides molecular determinants for signal transduction and cell surface expression. Journal of Biological Chemistry, 281 (3), pp. 1644-1651.

Koole, Cassandra; Wootten, Denise; Simms, John; Miller, Laurence J.; Christopoulos, Arthur and Sexton, Patrick M. Differential impact of amino acid substitutions on critical residues of the human glucagon-like peptide-1 receptor involved in peptide activity and small-molecule allosterys. Journal of Pharmacology and Experimental Therapeutics, 353 (1), pp. 52-63.

Chugunov, Anton O.; Simms, John; Poyner, David R.; Dehouck, Yves; Rooman, Marianne; Gilis, Dimitri and Langer, Ingrid Evidence that interaction between conserved residues in transmembrane helices 2, 3, and 7 are crucial for human VPAC1 receptor activation. Molecular Pharmacology, 78 (3), pp. 394-401.

Uddin, Romez; Simms, John and Poyner, David Functional characterisation of G protein-coupled receptors. Methods ,

Wheatley, M.; Wootten, Denise; Conner, Matthew T.; Simms, John; Kendrick, R.; Logan, R.T.; Poyner, David R. and Barwell, James Lifting the lid on GPCRs:the role of extracellular loops. British Journal of Pharmacology, 165 (6), pp. 1688-1703.

Sexton, Patrick M.; Poyner, David R.; Simms, John; Christopoulos, Arthur and Hay, Debbie L. Modulating receptor function through RAMPs:can they represent drug targets in themselves? Drug Discovery Today, 14 (7-8), pp. 413-419.

Sexton, Patrick M.; Poyner, David R.; Simms, John; Christopoulos, Arthur and Hay, Debbie L. RAMPs as drug targets. Advances in Experimental Medicine and Biology, 744 , pp. 61-74.

Woolley, Michael J.; Reynolds, Christopher A.; Simms, John; Walker, Christopher S.; Mobarec, Juan Carlos; Garelja, Michael L.; Conner, Alex C.; Poyner, David R. and Hay, Debbie L. Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs. Biochemical Pharmacology, in pre ,

Booe, Jason M.; Walker, Christopher S.; Barwell, James; Kuteyi, Gabriel; Simms, John; Jamaluddin, Muhammad A.; Warner, Margaret L.; Bill, Roslyn M.; Harris, Paul W.; Brimble, Margaret A.; Poyner, David R.; Hay, Debbie L. and Pioszak, Augen A. Structural basis for receptor activity-modifying protein-dependent selective peptide recognition by a G protein-coupled receptor. Molecular Cell, 58 (6), pp. 1040-1052.

Simms, John; Hay, Debbie L.; Bailey, Richard J.; Konycheva, Galina; Bailey, Graham; Wheatley, Mark and Poyner, David R. Structure-function analysis of RAMP1 by Alanine Mutagenesis. Biochemistry, 48 (1), pp. 198-205.

Woolley, Michael J.; Simms, John; Mobarec, Juan Carlos; Reynolds, Christopher A.; Poyner, David R. and Conner, Alex C. Understanding the molecular functions of the second extracellular loop (ECL2) of the calcitonin gene-related peptide (CGRP) receptor using a comprehensive mutagenesis approach. Molecular and Cellular Endocrinology, in pre ,

Gingell, Joseph J.; Simms, John; Barwell, James; Poyner, David R.; Watkins, Harriet A.; Pioszak, Augen A.; Sexton, Patrick M. and Hay, Debbie L. An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology. Cell Discovery, 2 ,

Conner, Alex C.; Hay, Debbie L.; Simms, John; Howitt, Stephen G.; Schindler, Marcus; Smith, David M.; Wheatley, Mark and Poyner, David R. A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling:implications for family B G-protein-coupled receptors. Molecular Pharmacology, 67 (1), pp. 20-31.