Browse by Aston Author

2017

Coudrat, Thomas; Simms, John; Christopoulos, Arthur; Wootten, Denise and Sexton, Patrick M. (2017). Improving virtual screening of G protein-coupled receptors via ligand-directed modeling. PLoS computational biology, 13 (11), e1005819.

Woolley, Michael J.; Simms, John; Uddin, Sifat; Poyner, David R. and Conner, Alex C. (2017). Relative antagonism of mutants of the CGRP receptor extracellular loop 2 domain (ECL2) using a truncated competitive antagonist (CGRP8-37):evidence for the dual involvement of ECL2 in the two-domain binding model. Biochemistry, 56 (30), pp. 3877-3880.

2016

Wootten, Denise; Reynolds, Christopher A.; Smith, Kevin J.; Mobarec, Juan C.; Koole, Cassandra; Savage, Emilia E.; Pabreja, Kavita; Simms, John; Sridhar, Rohan; Furness, Sebastian G.B.; Liu, Mengjie; Thompson, Philip E.; Miller, Laurence J.; Christopoulos, Arthur and Sexton, Patrick M. (2016). The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonism. Cell, 165 (7), pp. 1632-1643.

Wootten, Denise; Reynolds, Christopher A.; Koole, Cassandra; Smith, Kevin J.; Mobarec, Juan C.; Simms, John; Quon, Tezz; Coudrat, Thomas; Furness, Sebastian G.B.; Miller, Laurence J.; Christopoulos, Arthur and Sexton, Patrick M. (2016). A hydrogen-bonded polar network in the core of the glucagon-like peptide-1 receptor is a fulcrum for biased agonism:lessons from class B crystal structuress. Molecular Pharmacology, 89 (3), pp. 335-347.

2012

Barwell, James; Wootten, Denise; Simms, John; Hay, Debbie L. and Poyner, David R. (2012). RAMPs and CGRP receptors. Advances in Experimental Medicine and Biology, 744 , pp. 13-24.

2010

Qi, Tao; Simms, John; Bailey, Richard J.; Wheatley, Mark; L. Rathbone, Daniel; Hay, Debbie L. and Poyner, David R (2010). Structure-function analysis of RAMP1-RAMP3 chimeras. Biochemistry, 49 (3), pp. 522-531.

2006

Conner, Alex C.; Simms, John; Conner, Matthew T.; Wootten, Denise L.; Wheatley, Mark and Poyner, David R. (2006). Diverse functional motifs within the three intracellular loops of the CGRP1 receptor. Biochemistry, 45 (43), pp. 12976-12985.

Simms, John; Hay, Debbie L.; Wheatley, Mark and Poyner, David R. (2006). Characterization of the structure of RAMP1 by mutagenesis and molecular modeling. Biophysical Journal, 91 (2), pp. 662-669.

Conner, Alex C.; Simms, John; Howitt, Stephen G.; Wheatley, Mark and Poyner, David R. (2006). The second intracellular loop of the calcitonin gene-related peptide receptor provides molecular determinants for signal transduction and cell surface expression. Journal of Biological Chemistry, 281 (3), pp. 1644-1651.