Browse by Aston Author

Article

Hay, Debbie L.; Harris, Paul W.R.; Kowalczyk, Renata; Brimble, Margaret A.; Rathbone, Dan L; Barwell, James; Conner, Alex C. and Poyner, David R. (2014). Structure-activity relationships of the N-terminus of calcitonin gene-related peptide:key roles of alanine-5 and threonine-6 in receptor activation. British Journal of Pharmacology, 171 (2), pp. 415-426.

Watkins, Harriet A.; Rathbone, Dan L.; Barwell, James; Hay, Debbie L. and Poyner, David R (2013). Structure-activity relationships for α-calcitonin gene-related peptide. British Journal of Pharmacology, 170 (7), pp. 1308-1322.

Woolley, Michael J.; Watkins, Harriet A.; Taddese, Bruck; Karakullukcu, Z. Gamze; Barwell, James; Smith, Kevin J.; Hay, Debbie L.; Poyner, David R.; Reynolds, Christopher A. and Conner, Alex C. (2013). The role of ECL2 in CGRP receptor activation:a combined modelling and experimental approach. Journal of the Royal Society Interface, 10 (88),

Bonander, Nicklas; Jamshad, Mohammed; Oberthür, Dominik; Clare, Michelle; Barwell, James; Hu, Ke; Farquhar, Michelle J.; Stamataki, Zania; Harris, Helen J.; Dierks, Karsten; Dafforn, Timothy R.; Betzel, Christian; McKeating, Jane A. and Bill, Roslyn M. (2013). Production, purification and characterization of recombinant, full-length human claudin-1. PLoS ONE, 8 (5),

Vohra, Shabana; Taddese, Bruck; Conner, Alex C.; Poyner, David R.; Hay, Debbie L.; Barwell, James; Reeves, Philip J.; Upton, Graham J.G. and Reynolds, Christopher A. (2013). Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies. Journal of the Royal Society Interface, 10 (79),

Barwell, James; Wootten, Denise; Simms, John; Hay, Debbie L. and Poyner, David R. (2012). RAMPs and CGRP receptors. Advances in Experimental Medicine and Biology, 744 , pp. 13-24.

Barwell, James; Conner, Alex C. and Poyner, David R (2011). Extracellular loops 1 and 3 and their associated transmembrane regions of the calcitonin receptor-like receptor are needed for CGRP receptor function. BBA - Molecular Cell Research, 1813 (10), pp. 1906-1916.

Barwell, James; Gingell, Joseph J.; Watkins, Harriet A.; Archbold, Julia K.; Poyner, David R. and Hay, Debbie L. Calcitonin and calcitonin receptor-like receptors:common themes with family B GPCRs? British Journal of Pharmacology, 166 (1), pp. 51-65.

Wheatley, M.; Wootten, Denise; Conner, Matthew T.; Simms, John; Kendrick, R.; Logan, R.T.; Poyner, David R. and Barwell, James Lifting the lid on GPCRs:the role of extracellular loops. British Journal of Pharmacology, 165 (6), pp. 1688-1703.

Barwell, James; Miller, Philip S.; Donnelly, Dan and Poyner, David R. Mapping interaction sites within the N-terminus of the calcitonin gene-related peptide receptor; the role of residues 23-60 of the calcitonin receptor-like receptor. Peptides, 31 (1), pp. 170-176.

Miller, Philip S.; Barwell, James; Poyner, David R.; Wigglesworth, Mark J.; Garland, Stephen L. and Donnelly, Dan Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74. Biochemical and Biophysical Research Communications, 391 (1), pp. 437-442.

Watkins, Harriet A.; Chakravarthy, Madhuri; Abhayawardana, Rekhati S.; Gingell, Joseph J.; Garelja, Michael; Pardamwar, Meenakshi; McElhinney, James M.W.R.; Lathbridge, Alex; Constantine, Arran; Harris, Paul W.R.; Yuen, Tsz-Ying; Brimble, Margaret A.; Barwell, James; Poyner, David R.; Woolley, Michael J.; Conner, Alex C.; Pioszak, Augen A.; Reynolds, Christopher A. and Hay, Debbie L. Receptor activity-modifying proteins 2 and 3 generate adrenomedullin receptor subtypes with distinct molecular properties. Journal of Biological Chemistry, 291 (22), pp. 11657-11675.

Booe, Jason M.; Walker, Christopher S.; Barwell, James; Kuteyi, Gabriel; Simms, John; Jamaluddin, Muhammad A.; Warner, Margaret L.; Bill, Roslyn M.; Harris, Paul W.; Brimble, Margaret A.; Poyner, David R.; Hay, Debbie L. and Pioszak, Augen A. Structural basis for receptor activity-modifying protein-dependent selective peptide recognition by a G protein-coupled receptor. Molecular Cell, 58 (6), pp. 1040-1052.

Barwell, James; Wheatley, Mark; Conner, Alex C.; Taddese, Bruck; Vohra, Shabana; Reynolds, Christopher A. and Poyner, David R. The activation of the CGRP receptor. Biochemical Society Transactions, 41 (1), pp. 180-184.

Gingell, Joseph J.; Simms, John; Barwell, James; Poyner, David R.; Watkins, Harriet A.; Pioszak, Augen A.; Sexton, Patrick M. and Hay, Debbie L. An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology. Cell Discovery, 2 ,

Barwell, James; Woolley, Michael J.; Wheatley, Mark; Conner, Alex C. and Poyner, David R The role of the extracellular loops of the CGRP receptor, a family B GPCR. Biochemical Society Transactions, 40 (2), pp. 433-437.

Book Section

Conner, Alex C.; Barwell, James; Poyner, David R. and Wheatley, Mark The use of site-directed mutagenesis to study GPCRs. IN: Receptor signal transduction protocols. Willars, Gary B. and Challiss, R.A. John (eds) Methods in molecular biology (3rd ed). Humana Press.

Thesis

Barwell, James (2010). An insight into the activation mechanism of the calcatonin-gene-related peptide receptor. PHD thesis, Aston University.