Browse by Aston Author

Hay, Debbie L.; Harris, Paul W.R.; Kowalczyk, Renata; Brimble, Margaret A.; Rathbone, Dan L; Barwell, James; Conner, Alex C. and Poyner, David R. (2014). Structure-activity relationships of the N-terminus of calcitonin gene-related peptide:key roles of alanine-5 and threonine-6 in receptor activation. British Journal of Pharmacology, 171 (2), pp. 415-426.

Watkins, Harriet A.; Rathbone, Dan L.; Barwell, James; Hay, Debbie L. and Poyner, David R (2013). Structure-activity relationships for α-calcitonin gene-related peptide. British Journal of Pharmacology, 170 (7), pp. 1308-1322.

Woolley, Michael J.; Watkins, Harriet A.; Taddese, Bruck; Karakullukcu, Z. Gamze; Barwell, James; Smith, Kevin J.; Hay, Debbie L.; Poyner, David R.; Reynolds, Christopher A. and Conner, Alex C. (2013). The role of ECL2 in CGRP receptor activation:a combined modelling and experimental approach. Journal of the Royal Society Interface, 10 (88),

Bonander, Nicklas; Jamshad, Mohammed; Oberthür, Dominik; Clare, Michelle; Barwell, James; Hu, Ke; Farquhar, Michelle J.; Stamataki, Zania; Harris, Helen J.; Dierks, Karsten; Dafforn, Timothy R.; Betzel, Christian; McKeating, Jane A. and Bill, Roslyn M. (2013). Production, purification and characterization of recombinant, full-length human claudin-1. PLoS ONE, 8 (5),

Vohra, Shabana; Taddese, Bruck; Conner, Alex C.; Poyner, David R.; Hay, Debbie L.; Barwell, James; Reeves, Philip J.; Upton, Graham J.G. and Reynolds, Christopher A. (2013). Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies. Journal of the Royal Society Interface, 10 (79),

Barwell, James; Wootten, Denise; Simms, John; Hay, Debbie L. and Poyner, David R. (2012). RAMPs and CGRP receptors. Advances in Experimental Medicine and Biology, 744 , pp. 13-24.

Barwell, James; Conner, Alex C. and Poyner, David R (2011). Extracellular loops 1 and 3 and their associated transmembrane regions of the calcitonin receptor-like receptor are needed for CGRP receptor function. BBA - Molecular Cell Research, 1813 (10), pp. 1906-1916.

Barwell, James (2010). An insight into the activation mechanism of the calcatonin-gene-related peptide receptor. PHD thesis, Aston University.

Barwell, James; Gingell, Joseph J.; Watkins, Harriet A.; Archbold, Julia K.; Poyner, David R. and Hay, Debbie L. Calcitonin and calcitonin receptor-like receptors:common themes with family B GPCRs? British Journal of Pharmacology, 166 (1), pp. 51-65.

Wheatley, M.; Wootten, Denise; Conner, Matthew T.; Simms, John; Kendrick, R.; Logan, R.T.; Poyner, David R. and Barwell, James Lifting the lid on GPCRs:the role of extracellular loops. British Journal of Pharmacology, 165 (6), pp. 1688-1703.

Barwell, James; Miller, Philip S.; Donnelly, Dan and Poyner, David R. Mapping interaction sites within the N-terminus of the calcitonin gene-related peptide receptor; the role of residues 23-60 of the calcitonin receptor-like receptor. Peptides, 31 (1), pp. 170-176.

Miller, Philip S.; Barwell, James; Poyner, David R.; Wigglesworth, Mark J.; Garland, Stephen L. and Donnelly, Dan Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74. Biochemical and Biophysical Research Communications, 391 (1), pp. 437-442.

Watkins, Harriet A.; Chakravarthy, Madhuri; Abhayawardana, Rekhati S.; Gingell, Joseph J.; Garelja, Michael; Pardamwar, Meenakshi; McElhinney, James M.W.R.; Lathbridge, Alex; Constantine, Arran; Harris, Paul W.R.; Yuen, Tsz-Ying; Brimble, Margaret A.; Barwell, James; Poyner, David R.; Woolley, Michael J.; Conner, Alex C.; Pioszak, Augen A.; Reynolds, Christopher A. and Hay, Debbie L. Receptor activity-modifying proteins 2 and 3 generate adrenomedullin receptor subtypes with distinct molecular properties. Journal of Biological Chemistry, 291 (22), pp. 11657-11675.

Booe, Jason M.; Walker, Christopher S.; Barwell, James; Kuteyi, Gabriel; Simms, John; Jamaluddin, Muhammad A.; Warner, Margaret L.; Bill, Roslyn M.; Harris, Paul W.; Brimble, Margaret A.; Poyner, David R.; Hay, Debbie L. and Pioszak, Augen A. Structural basis for receptor activity-modifying protein-dependent selective peptide recognition by a G protein-coupled receptor. Molecular Cell, 58 (6), pp. 1040-1052.

Barwell, James; Wheatley, Mark; Conner, Alex C.; Taddese, Bruck; Vohra, Shabana; Reynolds, Christopher A. and Poyner, David R. The activation of the CGRP receptor. Biochemical Society Transactions, 41 (1), pp. 180-184.

Gingell, Joseph J.; Simms, John; Barwell, James; Poyner, David R.; Watkins, Harriet A.; Pioszak, Augen A.; Sexton, Patrick M. and Hay, Debbie L. An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology. Cell Discovery, 2 ,

Barwell, James; Woolley, Michael J.; Wheatley, Mark; Conner, Alex C. and Poyner, David R The role of the extracellular loops of the CGRP receptor, a family B GPCR. Biochemical Society Transactions, 40 (2), pp. 433-437.

Conner, Alex C.; Barwell, James; Poyner, David R. and Wheatley, Mark The use of site-directed mutagenesis to study GPCRs. IN: Receptor signal transduction protocols. Willars, Gary B. and Challiss, R.A. John (eds) Methods in molecular biology (3rd ed). Humana Press.