Browse by Aston Author

2025

Akram, Aneel, Hadasha, Waled, Kuyler, Gestél C., Smith, Michael-Phillip, Bailey-Dallaway, Shauna, Preedy, Aiden, Browne, Caolan, Broadbent, Luke, Hill, Adam, Javaid, Tahreem, Nazar, Haroon, Samra, Nikita, Naveed, Anadil, Tregunna, Holly, Joshi, Hetal, Akhtar, Nusheen, Javed, Aneesa, Bowater, Jessica, Ravenhill, Joel, Hajdu, Patrik, Ali, Yazdan, Tailor, Yanik, Mumtaz, Sabreen, Hamza, Mohammed, Gill, Kiran, Gillett, Jemma, Patton, Faye, Arshid, Huma, Zaheer, Maria, Qureshi, Hannah, Edwards, Isabel, Patel, Shreya, Azadi, Aaminah, Pollock, Naomi, Kitchen, Philip, Klumperman, Bert and Rothnie, Alice j. (2025). Solubilisation & purification of membrane proteins using benzylamine-modified SMA polymers. Biophysical Chemistry, 316 ,

2024

Upton, Calum, Healey, Joseph, Rothnie, Alice J. and Goddard, Alan D. (2024). Insights into membrane interactions and their therapeutic potential. Archives of Biochemistry and Biophysics, 755 ,

Broadbent, Luke M, Rothnie, Alice J, Simms, John and Bill, Roslyn M (2024). Classifying tetraspanins: A universal system for numbering residues and a proposal for naming structural motifs and subfamilies. Biochimica et biophysica acta. Biomembranes, 1866 (3), p. 184265.

2022

Iqbal, Shagufta, Flux, Caitlin, Briggs, Deborah A., Deplazes, Evelyne, Long, Jiansi, Skrzypek, Ruth, Rothnie, Alice, Kerr, Ian D. and Callaghan, Richard (2022). Vinca alkaloid binding to P-glycoprotein occurs in a processive manner. Biochimica et Biophysica Acta - Biomembranes, 1864 (10),

Rothnie, Alice, Patel, Jaimin, Pollock, Naomi L., Maher, Jacqueline and Allen, Marcus (2022). The function of BK channels extracted and purified within SMALPs. Biochemical Journal, 479 (15), pp. 1609-1619.

Broadbent, Luke, Depping, Peer, Lodé, Alexis, Vaitsopoulou, Afroditi, Hardy, David, Ayub, Hoor, Mitchell-White, James, Kerr, Ian D, Goddard, Alan D, Bill, Roslyn M and Rothnie, Alice J (2022). Detergent-Free Membrane Protein Purification Using SMA Polymer. IN: Methods in Molecular Biology. Mus-Veteau, I. (ed.) Methods in Molecular Biology, 2507 . Springer.

Depping, Peer, Román Lara, María Monserrat, Kesidis, Athanasios, Bill, Roslyn M, Rothnie, Alice J, Browning, Douglas F and Goddard, Alan D (2022). Heterologous Expression of Membrane Proteins in E. coli. IN: Heterologous Expression of Membrane Proteins. Mus-Veteau, I. (ed.) Methods in Molecular Biology, 2507 . Springer.

Vaitsopoulou, Afroditi, Depping, Peer, Bill, Roslyn M, Goddard, Alan D and Rothnie, Alice J (2022). Membrane Protein Production in Insect Cells. IN: Methods in Molecular Biology. Mus-Veteau, I. (ed.) Methods in Molecular Biology, 2507 . Springer.

2021

Hawkins, Olivia P., Jahromi, Christine Parisa T., Gulamhussein, Aiman A., Nestorow, Stephanie, Bahra, Taranpreet, Shelton, Christian, Owusu-mensah, Quincy K., Mohiddin, Naadiya, O'rourke, Hannah, Ajmal, Mariam, Byrnes, Kara, Khan, Madiha, Nahar, Nila N., Lim, Arcella, Harris, Cassandra, Healy, Hannah, Hasan, Syeda W., Ahmed, Asma, Evans, Lora, Vaitsopoulou, Afroditi, Akram, Aneel, Williams, Chris, Binding, Johanna, Thandi, Rumandeep K., Joby, Aswathy, Guest, Ashley, Tariq, Mohammad Z., Rasool, Farah, Cavanagh, Luke, Kang, Simran, Asparuhov, Biser, Jestin, Aleksandr, Dafforn, Timothy R., Simms, John, Bill, Roslyn M., Goddard, Alan D. and Rothnie, Alice J. (2021). Membrane protein extraction and purification using partially-esterified SMA polymers. BBA -Biomembranes, 1863 (12),

Rothnie, Alice, Unger, Lucas, Ronco-Campaña, Alejandro, Kitchen, Philip and Bill, Roslyn (2021). Biological Insights from SMA-extracted Proteins. Biochemical Society Transactions, 49 (3), pp. 1349-1359.

2020

Ayub, Hoor, Clare, Michelle, Milic, Ivana, Chmel, Nikola P., Böning, Heike, Devitt, Andrew, Krey, Thomas, Bill, Roslyn M. and Rothnie, Alice J. (2020). CD81 extracted in SMALP nanodiscs comprises two distinct protein populations within a lipid environment enriched with negatively charged headgroups. BBA -Biomembranes, 1862 (11),

Low, Floren G., Shabir, Kiran, Brown, James E., Bill, Roslyn M. and Rothnie, Alice J. (2020). Roles of ABCC1 and ABCC4 in Proliferation and Migration of Breast Cancer Cell Lines. International Journal of Molecular Sciences, 21 (20), pp. 1-21.

Rozo, Annaïg J., Cox, Megan H., Devitt, Andrew, Rothnie, Alice J. and Goddard, Alan D. (2020). Biophysical analysis of lipidic nanoparticles. Methods, 180 , pp. 45-55.

Kesidis, Athanasios, Depping, Peer, Lodé, Alexis, Vaitsopoulou, Afroditi, Bill, Roslyn M., Goddard, Alan D. and Rothnie, Alice J. (2020). Expression of eukaryotic membrane proteins in eukaryotic and prokaryotic hosts. Methods, 180 , pp. 3-18.

Gulamhussein, Aiman, Uddin, Romez, Tighe, Brian, Poyner, David and Rothnie, Alice (2020). A comparison of SMA (styrene maleic acid) and DIBMA (di-isobutylene maleic acid) for membrane protein purification. BBA -Biomembranes, 1862 (7),

Wiseman, Daniel N., Otchere, Abigail, Patel, Jaimin H., Uddin, Romez, Pollock, Naomi L., Routledge, Sarah J., Rothnie, Alice J., Slack, Cathy, Poyner, David R., Bill, Roslyn M. and Goddard, Alan D. (2020). Expression and purification of recombinant G protein-coupled receptors: A review. Protein Expression and Purification, 167 ,

2019

Hardy, David, Bill, Roslyn M, Jawhari, Anass and Rothnie, Alice J (2019). Functional expression of Multidrug Resistance Protein 4 MRP4/ABCC4. SLAS Discovery, 24 (10), pp. 1000-1008.

Hardy, David, Bill, Roslyn M, Rothnie, Alice J and Jawhari, Anass (2019). Stabilization of human Multidrug Resistance Protein 4 (MRP4/ABCC4) using novel solubilization agents. SLAS Discovery, 24 (10), pp. 1009-1017.

Gulamhussein, Aiman A., Meah, Danyall, Soja, Damian D., Fenner, Stephen, Saidani, Zakaria, Akram, Aneel, Lallie, Simran, Mathews, Ashlyn, Painter, Culum, Liddar, Monique K., Mohammed, Zain, Ki Chiu, Lai, Sumar, Sabiha S., Healy, Hannah, Hussain, Nabeel, Patel, Jaimin H., Hall, Stephen C.l., Dafforn, Timothy R. and Rothnie, Alice J. (2019). Examining the stability of membrane proteins within SMALPs. European Polymer Journal, 112 , pp. 120-125.

2018

Hardy, David, Desuzinges Mandon, Elodie, Rothnie, Alice and Jawhari, Anass (2018). The yin and yang of solubilization and stabilization for wild-type and full-length membrane protein. Methods, 147 , pp. 118-125.

Weigl, Kevin E., Conseil, Gwenaëlle, Rothnie, Alice J., Arama, May, Tsfadia, Yossi and Cole, Susan P.C. (2018). An outward-facing aromatic amino acid is crucial for signaling between the membrane-spanning and nucleotide-binding domains of multidrug resistance protein 1 (MRP1; ABCC1) s. Molecular Pharmacology, 94 (3), pp. 1069-1078.

Hall, Stephen C.L., Tognoloni, Cecilia, Charlton, Jack, Bragginton, Éilís C., Rothnie, Alice J, Sridhar, Pooja, Wheatley, Mark, Knowles, Timothy J., Arnold, Thomas, Edler, Karen J. and Dafforn, Timothy R. (2018). An acid-compatible co-polymer for the solubilization of membranes and proteins into lipid bilayer-containing nanoparticles. Nanoscale, 10 , pp. 10609-10619.

Pollock, Naomi L., Lee, Sarah C., Patel, Jaimin H., Gulamhussein, Aiman A. and Rothnie, Alice J. (2018). Structure and function of membrane proteins encapsulated in a polymer-bound lipid bilayer. BBA -Biomembranes, 1860 (4), pp. 809-817.

2017

Dannhauser, Philip N., Camus, Stéphane M., Sakamoto, Kazuho, Sadacca, L. Amanda, Torres, Jorge A., Camus, Marine D., Briant, Kit, Vassilopoulos, Stéphane, Rothnie, Alice, Smith, Corinne J. and Brodsky, Frances M. (2017). CHC22 and CHC17 clathrins have distinct biochemical properties and display differential regulation and function. Journal of Biological Chemistry, 292 (51), pp. 20834-20844.

2016

Morrison, Kerrie A., Akram, Aneel, Mathews, Ashlyn, Khan, Zoeya A., Patel, Jaimin H., Zhou, Chumin, Hardy, David John, Moore-Kelly, Charles, Patel, Roshani, Odiba, Victor, Knowles, Tim, Javed, Masood-ul-Hassan, Chmel, Nikola P., Dafforn, Timothy R. and Rothnie, Alice Jane (2016). Membrane protein extraction and purification using styrene-maleic acid (SMA) co-polymer:effect of variations in polymer structure. Biochemical Journal, 473 (23), pp. 4349-4360.

Lee, Sarah C., Khalid, Syma, Pollock, Naomi L., Knowles, Timothy J., Edler, Karen, Rothnie, Alice J., Thomas, Owen R.T. and Dafforn, Timothy R. (2016). Encapsulated membrane proteins: a simplified system for molecular simulation. BBA -Biomembranes, 1858 (10), pp. 2549-2557.

Hardy, David, Bill, Roslyn M., Jawhari, Anass and Rothnie, Alice J. (2016). Overcoming bottlenecks in the membrane protein structural biology pipeline. Biochemical Society Transactions, 44 (3), pp. 838-844.

Routledge, Sarah, Mikaliunaite, Lina, Patel, Anjana, Clare, Michelle, Cartwright, Stephanie P., Bawa, Zharain, Wilks, Martin D.B., Low, Floren, Hardy, David, Rothnie, Alice J. and Bill, Roslyn M. (2016). The synthesis of recombinant membrane proteins in yeast for structural studies. Methods, 95 , pp. 26-37.

Currinn, Heather, Guscott, Benjamin, Balklava, Zita, Rothnie, Alice and Wassmer, Thomas (2016). APP controls the formation of PI(3,5)P2 vesicles through its binding of the PIKfyve complex. Cellular and Molecular Life Sciences, 73 (2), pp. 393-408.

2015

Lin, Ya-Huei, Currinn, Heather, Pocha, Shirin Meher, Rothnie, Alice, Wassmer, Thomas and Knust, Elisabeth (2015). AP-2 complex-mediated endocytosis of Drosophila Crumbs regulates polarity via antagonizing Stardust. Journal of Cell Science, 128 (24), pp. 4538-4549.

2014

Gulati, Sonali, Jamshad, Mohammed, Knowles, Timothy J., Morrison, Kerrie A., Downing, Rebecca, Cant, Natasha, Collins, Richard, Koenderink, Jan B., Ford, Robert C., Overduin, Michael, Kerr, Ian D., Dafforn, Timothy R. and Rothnie, Alice J. (2014). Detergent-free purification of ABC (ATP-binding-cassette) transporters. Biochemical Journal, 461 (2), pp. 269-278.

2013

Young, Anna, Stoilova-McPhie, Svetla, Rothnie, Alice, Vallis, Yvonne, Harvey-Smith, Phillip, Ranson, Neil, Kent, Helen, Brodsky, Frances M., Pearse, Barbara M.F., Roseman, Alan and Smith, Corinne J. (2013). Hsc70-induced changes in clathrin-auxilin cage structure suggest a role for clathrin light chains in cage disassembly. Traffic, 14 (9), pp. 987-996.

2011

Rothnie, Alice, Clarke, Anthony R., Kuzmic, Petr, Cameron, Angus and Smith, Corinne J. (2011). A sequential mechanism for clathrin cage disassembly by 70-kDa heat-shock cognate protein (Hsc70) and auxilin. Proceedings of the National Academy of Sciences, 108 (17), pp. 6927-6932.

2009

Heikal, Adam, Box, Karl, Rothnie, Alice, Storm, Janet, Callaghan, Richard and Allen, Marcus (2009). The stabilisation of purified, reconstituted P-glycoprotein by freeze drying with disaccharides. Cryobiology, 58 (1), pp. 37-44.

2004

Rothnie, Alice, Storm, Janet, Campbell, Jeff, Linton, Kenneth J., Kerr, Ian D. and Callaghan, Richard (2004). The topography of transmembrane segment six is altered during the catalytic cycle of P-glycoprotein. Journal of Biological Chemistry, 279 (33), pp. 34913-34921.

2003

Martin, C., Walker, J., Rothnie, A. and Callaghan, R. (2003). The expression of P-glycoprotein does influence the distribution of novel fluorescent compounds in solid tumour models. British Journal of Cancer, 89 (8), pp. 1581-1589.