Insights into membrane interactions and their therapeutic potential

Abstract

Recent research into membrane interactions has uncovered a diverse range of therapeutic opportunities through the bioengineering of human and non-human macromolecules. Although the majority of this research is focussed on fundamental developments, emerging studies are showcasing promising new technologies to combat conditions such as cancer, Alzheimer's and inflammatory and immune-based disease, utilising the alteration of bacteriophage, adenovirus, bacterial toxins, type 6 secretion systems, annexins, mitochondrial antiviral signalling proteins and bacterial nano-syringes. To advance the field further, each of these opportunities need to be better understood, and the therapeutic models need to be further optimised. Here, we summarise the knowledge and insights into several membrane interactions and detail their current and potential uses therapeutically.

Publication DOI: https://doi.org/10.1016/j.abb.2024.109939
Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences
Funding Information: CU is part of the MIBTP (Midlands Integrative Biosciences Training Partnership) doctoral training centre funded by the BBSRC (Biotechnology and Biological Sciences Research Council).
Additional Information: Copyright © 2024. Published by Elsevier Inc. This accepted manuscript version is licensed under under the terms of the Creative Commons Attribution License CC BY [https://creativecommons.org/licenses/by/4.0/], which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords: Membrane interactions,Biotechnology,Bacteriophage T4,Adenovirus,Photorhabdus virulence cassette
Publication ISSN: 1096-0384
Last Modified: 22 Feb 2024 08:17
Date Deposited: 21 Feb 2024 18:07
Full Text Link:
Related URLs: https://linking ... 003986124000584 (Publisher URL)
PURE Output Type: Article
Published Date: 2024-02-21
Published Online Date: 2024-02-21
Accepted Date: 2024-02-19
Authors: Upton, Calum
Healey, Joseph
Rothnie, Alice J. (ORCID Profile 0000-0002-4259-7015)
Goddard, Alan D. (ORCID Profile 0000-0003-4950-7470)

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License: Creative Commons Attribution

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