De Felice, Sara, Romani, Cristina, Geberhiwot, Tarekegn, Macdonald, Anita and Palermo, Liana (2018). Language processing and executive functions in early treated adults with phenylketonuria (PKU). Cognitive Neuropsychology, 34 (3-4), pp. 148-170.
Abstract
We provide an in-depth analysis of language functions in early-treated adults with phenylketonuria (AwPKUs, N = 15–33), as compared to age- and education-matched controls (N = 24–32; N varying across tasks), through: a. narrative production (the Cinderella story), b. language pragmatics comprehension (humour, metaphors, inferred meaning), c. prosody discrimination d. lexical inhibitory control and planning (Blocked Cyclic Naming; Hayling Sentence Completion Test, Burgess & Shallice, 1997). AwPKUs exhibited intact basic language processing (lexical retrieval, phonology/articulation, sentence construction). Instead, deficits emerged in planning and reasoning abilities. Compared to controls, AwPKUs were: less informative in narrative production (lower rate of Correct Information Units); slower in metaphorical understanding and inferred meaning; less accurate in focused lexical-search (Hayling test). These results suggest that i) executive deficits in PKU cannot be explained by an accumulation of lower-order deficits and/or general speed impairments, ii) executive functions engage dedicated neurophysiological resources, rather than simply being an emergent property of lower-level systems.
Publication DOI: | https://doi.org/10.1080/02643294.2017.1422709 |
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Divisions: | College of Health & Life Sciences > School of Psychology College of Health & Life Sciences > Clinical and Systems Neuroscience College of Health & Life Sciences College of Health & Life Sciences > School of Optometry > Vision, Hearing and Language |
Additional Information: | This is an Accepted Manuscript of an article published by Taylor & Francis Group in Cognitive Neuropsychology on 28 Feb 2018, available online at: http://www.tandfonline.com/10.1080/02643294.2017.1422709 |
Publication ISSN: | 1464-0627 |
Last Modified: | 14 Aug 2024 07:04 |
Date Deposited: | 30 Apr 2018 13:05 |
Full Text Link: | |
Related URLs: |
https://www.tan ... 94.2017.1422709
(Publisher URL) |
PURE Output Type: | Article |
Published Date: | 2018-05-19 |
Published Online Date: | 2018-02-28 |
Accepted Date: | 2017-12-21 |
Authors: |
De Felice, Sara
Romani, Cristina ( ![]() Geberhiwot, Tarekegn Macdonald, Anita Palermo, Liana ( ![]() |