Browse by Aston Author

2022

Odoemelam, Chiemela S., Hunter, Elena, Simms, John, Ahmad, Zeeshan, Chang, Ming-Wei, Percival, Benita, Williams, Ian H., Molinari, Marco, Kamerlin, Shina Caroline Lynn and Wilson, Philippe B. (2022). In Silico Ligand Docking Approaches to Characterise the Binding of Known Allosteric Modulators to the Glucagon-Like Peptide 1 Receptor and Prediction of ADME/Tox Properties. Applied Biosciences, 1 (2), pp. 143-162.

Bignold, Rebecca, Shammout, Bushra, Rowley, Jessica E., Repici, Mariaelena, Simms, John and Johnson, Jill R. (2022). Chemokine CXCL12 drives pericyte accumulation and airway remodeling in allergic airway disease. Respiratory Research, 23 (1),

Winfield, Ian, Barkan, Kerry, Routledge, Sarah, Robertson, Nathan J., Harris, Matthew, Jazayeri, Ali, Simms, John, Reynolds, Christopher A., Poyner, David R. and Ladds, Graham (2022). The Role of ICL1 and H8 in Class B1 GPCRs; Implications for Receptor Activation. Frontiers in Endocrinology, 12 ,

2021

Hawkins, Olivia P., Jahromi, Christine Parisa T., Gulamhussein, Aiman A., Nestorow, Stephanie, Bahra, Taranpreet, Shelton, Christian, Owusu-mensah, Quincy K., Mohiddin, Naadiya, O'rourke, Hannah, Ajmal, Mariam, Byrnes, Kara, Khan, Madiha, Nahar, Nila N., Lim, Arcella, Harris, Cassandra, Healy, Hannah, Hasan, Syeda W., Ahmed, Asma, Evans, Lora, Vaitsopoulou, Afroditi, Akram, Aneel, Williams, Chris, Binding, Johanna, Thandi, Rumandeep K., Joby, Aswathy, Guest, Ashley, Tariq, Mohammad Z., Rasool, Farah, Cavanagh, Luke, Kang, Simran, Asparuhov, Biser, Jestin, Aleksandr, Dafforn, Timothy R., Simms, John, Bill, Roslyn M., Goddard, Alan D. and Rothnie, Alice J. (2021). Membrane protein extraction and purification using partially-esterified SMA polymers. BBA -Biomembranes, 1863 (12),

2020

Routledge, Sarah J., Jamshad, Mohammed, Little, Haydn A., Lin, Yu Pin, Simms, John, Thakker, Alpesh, Spickett, Corinne M., Bill, Roslyn M., Dafforn, Tim R., Poyner, David R. and Wheatley, Mark (2020). Ligand-induced conformational changes in a SMALP-encapsulated GPCR. Biochimica et Biophysica Acta - Biomembranes, 1862 (6),

Lee, Sang-min, Jeong, Yejin, Simms, John, Warner, Margaret L., Poyner, David R., Chung, Ka Young and Pioszak, Augen A. (2020). Calcitonin receptor N-glycosylation enhances peptide hormone affinity by controlling receptor dynamics. Journal of Molecular Biology, 432 (7), pp. 1996-2014.

Routledge, Sarah J., Simms, John, Clark, Ashley, Yeung, Ho Yan, Wigglesworth, Mark J., Dickerson, Ian M., Kitchen, Philip, Ladds, Graham and Poyner, David R. (2020). Receptor component protein, an endogenous allosteric modulator of family B G protein coupled receptors. BBA -Biomembranes, 1862 (3),

2018

Uddin, Romez, Simms, John and Poyner, David (2018). Functional characterisation of G protein-coupled receptors. Methods, 147 , pp. 213-220.

Mackie, Duncan I., Al Mutairi, Fuad, Davis, Reema B., Kechele, Daniel O., Nielsen, Natalie R., Snyder, Joshua C., Caron, Marc G., Kliman, Harvey J., Berg, Jonathan S., Simms, John, Poyner, David R. and Caron, Kathleen M. (2018). hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia. Journal of Experimental Medicine, 215 (9), pp. 2339-2353.

Simms, John, Uddin, Romez, Sakmar, Thomas P., Gingell, Joseph J., Garelja, Michael L., Hay, Debbie L., Brimble, Margaret A., Harris, Paul W. R., Reynolds, Christopher Arthur and Poyner, David R. (2018). Photoaffinity cross-linking and unnatural amino acid mutagenesis reveal insights into calcitonin gene-related peptide binding to the calcitonin receptor-like receptor/receptor activity-modifying protein 1 (CLR/RAMP1) complex. Biochemistry, 57 (32), pp. 4915-4922.

2017

Coudrat, Thomas, Simms, John, Christopoulos, Arthur, Wootten, Denise and Sexton, Patrick M. (2017). Improving virtual screening of G protein-coupled receptors via ligand-directed modeling. PLoS computational biology, 13 (11),

Woolley, Michael J., Reynolds, Christopher A., Simms, John, Walker, Christopher S., Mobarec, Juan Carlos, Garelja, Michael L., Conner, Alex C., Poyner, David R. and Hay, Debbie L. (2017). Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs. Biochemical Pharmacology, 142 , pp. 96-110.

Woolley, Michael J., Simms, John, Mobarec, Juan Carlos, Reynolds, Christopher A., Poyner, David R. and Conner, Alex C. (2017). Understanding the molecular functions of the second extracellular loop (ECL2) of the calcitonin gene-related peptide (CGRP) receptor using a comprehensive mutagenesis approach. Molecular and Cellular Endocrinology, 454 , pp. 39-49.

Woolley, Michael J., Simms, John, Uddin, Sifat, Poyner, David R. and Conner, Alex C. (2017). Relative antagonism of mutants of the CGRP receptor extracellular loop 2 domain (ECL2) using a truncated competitive antagonist (CGRP8-37):evidence for the dual involvement of ECL2 in the two-domain binding model. Biochemistry, 56 (30), pp. 3877-3880.

2016

Wootten, Denise, Reynolds, Christopher A., Smith, Kevin J., Mobarec, Juan C., Koole, Cassandra, Savage, Emilia E., Pabreja, Kavita, Simms, John, Sridhar, Rohan, Furness, Sebastian G.B., Liu, Mengjie, Thompson, Philip E., Miller, Laurence J., Christopoulos, Arthur and Sexton, Patrick M. (2016). The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonism. Cell, 165 (7), pp. 1632-1643.

Gingell, Joseph J., Simms, John, Barwell, James, Poyner, David R., Watkins, Harriet A., Pioszak, Augen A., Sexton, Patrick M. and Hay, Debbie L. (2016). An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology. Cell Discovery, 2 ,

2015

Booe, Jason M., Walker, Christopher S., Barwell, James, Kuteyi, Gabriel, Simms, John, Jamaluddin, Muhammad A., Warner, Margaret L., Bill, Roslyn M., Harris, Paul W., Brimble, Margaret A., Poyner, David R., Hay, Debbie L. and Pioszak, Augen A. (2015). Structural basis for receptor activity-modifying protein-dependent selective peptide recognition by a G protein-coupled receptor. Molecular Cell, 58 (6), pp. 1040-1052.

2014

Harris, Nicola J., Findlay, Heather E., Simms, John, Liu, Xia and Booth, Paula J. (2014). Relative domain folding and stability of a membrane transport protein. Journal of Molecular Biology, 426 (8), pp. 1812-1825.

2012

Koole, Cassandra, Wootten, Denise, Simms, John, Savage, Emilia E., Miller, Laurence J., Christopoulos, Arthur and Sexton, Patrick M. (2012). Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function. Journal of Biological Chemistry, 287 (6), pp. 3659-3673.

Koole, Cassandra, Wootten, Denise, Simms, John, Miller, Laurence J., Christopoulos, Arthur and Sexton, Patrick M. (2012). Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation. Journal of Biological Chemistry, 287 (6), pp. 3642-3658.

2009

Harikumar, Kaleeckal G., Simms, John, Christopoulos, George, Sexton, Patrick M. and Miller, Laurence J. (2009). Molecular basis of association of receptor activity-modifying protein 3 with the family B G protein-coupled secretin receptor. Biochemistry, 48 (49), pp. 11773-11785.

2007

Conner, Matthew, Hawtin, Stuart R., Simms, John, Wootten, Denise, Lawson, Zoe, Conner, Alex C., Parslow, Rosemary A. and Wheatley, Mark (2007). Systematic analysis of the entire second extracellular loop of the V 1a vasopressin receptor :Key residues, conserved throughout a G-protein-coupled receptor family, identified. Journal of Biological Chemistry, 282 (24), pp. 17405-17412.

2006

Hawtin, Stuart R., Simms, John, Conner, Matthew, Lawson, Zoe, Parslow, Rosemary A., Trim, Julie, Sheppard, Andrew and Wheatley, Mark (2006). Charged extracellular residues, conserved throughout a G-protein-coupled receptor family, are required for ligand binding, receptor activation, and cell-surface expression. Journal of Biological Chemistry, 281 (50), pp. 38487-38488.

Conner, Alex C., Simms, John, Howitt, Stephen G., Wheatley, Mark and Poyner, David R. (2006). The second intracellular loop of the calcitonin gene-related peptide receptor provides molecular determinants for signal transduction and cell surface expression. Journal of Biological Chemistry, 281 (3), pp. 1644-1651.