Jones, Lyndon, Craig, Jennifer P., Markoulli, Maria, Karpecki, Paul, Akpek, Esen K., Basu, Sayan, Bitton, Etty, Chen, Wei, Dhaliwal, Deepinder K., Dogru, Murat, Gomes, José Alvaro P., Koehler, Miranda, Mehta, Jodhbir S., Perez, Victor L., Stapleton, Fiona, Sullivan, David A., Tauber, Joseph, Tong, Louis, Travé-Huarte, Sònia, Wolffsohn, James S., Alves, Monica, Baudouin, Christophe, Downie, Laura, Giannaccare, Giuseppe, Horwath-Winter, Jutta, Liu, Zuguo, Koh, Shizuka, Elisabeth, Messmer, Otero, Ernesto, Villani, Edoardo, Watson, Stephanie, Yoon, Kyung Chul and collaborator group, TFOS (2025). TFOS DEWS III 管理与治疗报告. American Journal of Ophthalmology ,
Abstract
本报告基于循证医学, 综述了当前干眼病(DED)的治疗策略.干眼病的一线治疗主要聚焦于泪液补充,保存和刺激泪液分泌, 尤其是泪液补充剂, 这些仍是干眼病治疗的基石.睑板腺功能障碍 (MGD) 作为干眼病的主要病因, 通常采用热敷及多种门诊治疗手段, 包括设备驱动的眼睑加热技术,强脉冲光治疗,低强度光疗法及其他新兴技术.睑缘清洁治疗则包括睑缘清洁湿巾,抗蠕形螨治疗,睑缘去角质术及局部抗生素的应用. 部分病因导致的干眼病可采用包括皮质类固醇,局部T细胞免疫调节药物及多种药理制剂的抗炎治疗, 以及生物性泪液替代物(如自体血清和富血小板血浆)治疗.经鼻神经刺激的神经调节及新型药物治疗, 为未来干眼病的治疗提供了更多选择.对于严重或难治性病例, 羊膜移植和复杂手术方法等进阶治疗可提供解决方案.生活方式调整(包括改善眨眼习惯,膳食补充和环境调节)在干眼病的长期管理中发挥重要作用.患者教育及对治疗的依从性对干眼症状的缓解同样至关重要. TFOS DEWS III 治疗指南提供了一个循证框架, 帮助临床医生根据不同病因选择相应干预措施, 以实现针对不同类型干眼病的精准管理.
| Publication DOI: | https://doi.org/10.1016/j.ajo.2025.11.024 |
|---|---|
| Divisions: | College of Health & Life Sciences > School of Optometry > Optometry & Vision Science Research Group (OVSRG) College of Health & Life Sciences College of Health & Life Sciences > School of Optometry > Optometry Aston University (General) |
| Additional Information: | Copyright © 2025 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license: https://creativecommons.org/licenses/by/4.0/ |
| Uncontrolled Keywords: | 人工泪液,干眼病,生活方式建议,管理,治疗,药物,药理学,Ophthalmology |
| Publication ISSN: | 1879-1891 |
| Last Modified: | 05 Feb 2026 08:07 |
| Date Deposited: | 04 Feb 2026 17:08 |
| Full Text Link: | |
| Related URLs: |
https://www.ajo ... 0623-3/fulltext
(Publisher URL) http://www.scop ... tnerID=8YFLogxK (Scopus URL) |
PURE Output Type: | Review article |
| Published Date: | 2025-11-21 |
| Published Online Date: | 2025-11-21 |
| Accepted Date: | 2025-11-01 |
| Authors: |
Jones, Lyndon
Craig, Jennifer P. Markoulli, Maria Karpecki, Paul Akpek, Esen K. Basu, Sayan Bitton, Etty Chen, Wei Dhaliwal, Deepinder K. Dogru, Murat Gomes, José Alvaro P. Koehler, Miranda Mehta, Jodhbir S. Perez, Victor L. Stapleton, Fiona Sullivan, David A. Tauber, Joseph Tong, Louis Travé-Huarte, Sònia ( 
0000-0001-5604-0042)
Wolffsohn, James S. (
0000-0003-4673-8927)
Alves, Monica Baudouin, Christophe Downie, Laura Giannaccare, Giuseppe Horwath-Winter, Jutta Liu, Zuguo Koh, Shizuka Elisabeth, Messmer Otero, Ernesto Villani, Edoardo Watson, Stephanie Yoon, Kyung Chul collaborator group, TFOS |
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