Enhancing Transcranial Blood Flow Visualization with Dynamic Light Scattering Technologies: Advances in Quantitative Analysis

Abstract

A comparative application of major dynamic light scattering (DLS)-based image methodologies applied to transcranial cerebral blood flow imaging is presented. In particular, the study delves into assessing capability of Laser Doppler Flowmetry (LDF), Laser Speckle Contrast Imaging (LSCI), and Diffuse Correlation Spectroscopy (DCS) in enhancing the spatial and temporal resolution of transcranial blood flow imaging. An integral part of the study is focused on the modulation of blood flow through the administration of the vasodilator drug, Sodium Nitroprusside (SNP). This pharmacological intervention facilitated a direct observation of cerebral vasculature's responsiveness to external stimuli, illuminating the physiological adaptations within the brain's microvascular architecture. Advanced LSCI processing techniques are incorporated, notably entropy and principal component analysis (PCA). Entropy is providing a quantifiable measure of the randomness and complexity within the speckle patterns of transcranial blood flow images, revealing remarkably similar outcomes with DSC approach in terms of blood flow dynamics and its quantitative evaluation. The application of PCA approach is provided a more nuanced understanding of blood flow dynamics, facilitating the identification of subtle changes induced by drug administration. This method proved instrumental in enhancing the visualization and detection of nuanced blood flow dynamics, thereby allowing for a more detailed examination of cerebral circulation alterations induced by SNP administration. The study seeks to offer a wider-ranging insight into comprehending the translating further the concept of DLS into transcrainial blood flow vizualization and explore its practical applications, considering hardware, advanced quantitative image processing, and data acquisition.

Publication DOI: https://doi.org/10.1002/lpor.202401016
Divisions: College of Engineering & Physical Sciences > School of Engineering and Technology > Mechanical, Biomedical & Design
College of Engineering & Physical Sciences > Engineering for Health
College of Health & Life Sciences
College of Engineering & Physical Sciences
Aston University (General)
Funding Information: This study is based upon work from COST Action CA21159 - Understanding interaction light - biological surfaces: the possibility for new electronic materials and devices (PhoBioS), supported by COST (European Cooperation in Science and Technology). This st
Additional Information: Copyright © 2024 The Author(s). Laser & Photonics Reviews published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords: anscranial visualisation,blood flow,diffuse correlation spectroscopy (DCS),entropy,laser doppler flowmetry (LDF),laser speckle contrast imageing (LSCI),PCA,tr hemodynamics
Publication ISSN: 1863-8899
Data Access Statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Last Modified: 21 Nov 2024 08:22
Date Deposited: 26 Sep 2024 12:19
Full Text Link:
Related URLs: https://onlinel ... /lpor.202401016 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2024-09-20
Published Online Date: 2024-09-20
Accepted Date: 2024-08-28
Authors: Zherebtsov, Evgeny
Sdobnov, Anton
Sieryi, Oleksii
Kaakinen, Mika
Eklund, Lauri
Myllylä, Teemu
Bykov, Alexander V.
Meglinski, Igor (ORCID Profile 0000-0002-7613-8191)

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