Transcription activation in Escherichia coli and Salmonella


Promoter-specific activation of transcript initiation provides an important regulatory device in Escherichia coli and Salmonella. Here, we describe the different mechanisms that operate, focusing on how they have evolved to manage the "housekeeping" bacterial transcription machinery. Some mechanisms involve assisting the bacterial DNA-dependent RNA polymerase or replacing or remodeling one of its subunits. Others are directed to chromosomal DNA, improving promoter function, or relieving repression. We discuss how different activators work together at promoters and how the present complex network of transcription factors evolved.

Publication DOI:
Divisions: College of Health & Life Sciences > School of Biosciences
Funding Information: This work was generously supported by the Biotechnology and Biological Sciences Research Council (BBSRC) through research grant BB/W00285X/1 to S.J.W.B and D.F.B.
Additional Information: Copyright © 2024, American Society for Microbiology. This is an accepted manuscript of an article published in EcoSal Plus. The published version is available at: []. This accepted manuscript version is licensed under the Creative Commons Attribution License CC BY [], which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The images and figures are not included in the manuscript's Creative Commons licence. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
Uncontrolled Keywords: Bacteria,Escherichi coli,promoters,transcription,initiation,RNA polymerase,transcription factors,sigma factors,stress adaptation,evolution
Publication ISSN: 2324-6200
Last Modified: 27 Jun 2024 11:48
Date Deposited: 16 Feb 2024 12:03
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Related URLs: https://journal ... s.esp-0039-2020 (Publisher URL)
PURE Output Type: Review article
Published Date: 2024-02-12
Published Online Date: 2024-02-12
Accepted Date: 2023-12-23
Authors: Busby, Stephen J. W.
Browning, Douglas F. (ORCID Profile 0000-0003-4672-3514)



Version: Accepted Version

License: Creative Commons Attribution

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