Language and reading impairments are associated with increased prevalence of non‐right‐handedness

Abstract

Handedness has been studied for association with language‐related disorders because of its link with language hemispheric dominance. No clear pattern has emerged, possibly because of small samples, publication bias, and heterogeneous criteria across studies. Non‐right‐handedness (NRH) frequency was assessed in N = 2503 cases with reading and/or language impairment and N = 4316 sex‐matched controls identified from 10 distinct cohorts (age range 6–19 years old; European ethnicity) using a priori set criteria. A meta‐analysis (Ncases = 1994) showed elevated NRH % in individuals with language/reading impairment compared with controls (OR = 1.21, CI = 1.06–1.39, p = .01). The association between reading/language impairments and NRH could result from shared pathways underlying brain lateralization, handedness, and cognitive functions.

Publication DOI: https://doi.org/10.1111/cdev.13914
Divisions: College of Health & Life Sciences > School of Psychology
College of Health & Life Sciences > Aston Institute of Health & Neurodevelopment (AIHN)
College of Health & Life Sciences > Clinical and Systems Neuroscience
College of Health & Life Sciences
College of Health & Life Sciences > School of Optometry > Vision, Hearing and Language
Additional Information: Copyright © 2023 The Authors. Child Development published by Wiley Periodicals LLC on behalf of Society for Research in Child Development. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Research Funding: Silvia Paracchini and Filippo Abbondanza are funded by the Royal Society (UF150663; RGF\EA\180141). The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors and will serve as guarantors for the contents of this paper. A comprehensive list of grants funding is available on the ALSPAC website: http://www.brist ol.ac.uk/alspa c/exter nal/docum ents/grant-acknowledgements.pdf. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Elsje van Bergen was supported by NWO VENI fellowship 451-15- 017. Support for the Toronto cohort collection was provided by grants from the Canadian Institutes of Health Research (MOP-133440). K.M.P. was supported by the Hospital for Sick Children Research Training Program (Restracomp). Simon Fisher is funded by the Max Planck Society. Dorothy Bishop is funded by European Research Council Advanced Grant 694189. Andrew Whitehouse is supported by an Investigator Grant from the National Health and Medical Research Council (1173896). The Raine Study was supported by the National Health and Medical Research Council of Australia (grant numbers 572613, 403981, 1059711), and the Canadian Institutes of Health Research (grant number MOP-82893). The Multicenter Study Marburg/Würzburg cohort was funded by the Deutsche Forschungsgemeinschaft (DFG).
Publication ISSN: 0009-3920
Last Modified: 28 Feb 2024 08:28
Date Deposited: 14 Feb 2023 11:11
Full Text Link:
Related URLs: https://srcd.on ... 1111/cdev.13914 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2023-07-01
Published Online Date: 2023-02-13
Accepted Date: 2022-12-12
Submitted Date: 2022-03-19
Authors: Abbondanza, Filippo
Dale, Philip S.
Wang, Carol A.
Hayiou‐Thomas, Marianna E.
Toseeb, Umar
Koomar, Tanner S.
Wigg, Karen G.
Feng, Yu
Price, Kaitlyn M.
Kerr, Elizabeth N.
Guger, Sharon L.
Lovett, Maureen W.
Strug, Lisa J.
van Bergen, Elsje
Dolan, Conor V.
Tomblin, J. Bruce
Moll, Kristina
Schulte‐Körne, Gerd
Neuhoff, Nina
Warnke, Andreas
Fisher, Simon E.
Barr, Cathy L.
Michaelson, Jacob J.
Boomsma, Dorret I.
Snowling, Margaret J.
Hulme, Charles
Whitehouse, Andrew J. O.
Pennell, Craig E.
Newbury, Dianne F.
Stein, John
Talcott, Joel B. (ORCID Profile 0000-0001-7958-8369)
Bishop, Dorothy V. M.
Paracchini, Silvia

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