Romani, Cristina, Olson, Andrew, Aitkenhead, Lynne, Baker, Lucy, Patel, Dhanesha, Spronsen, Francjan Van, MacDonald, Anita, Wegberg, Annemiek van and Huijbregts, Stephan (2022). Meta-analyses of cognitive functions in early-treated adults with phenylketonuria. Neuroscience and Biobehavioral Reviews, 143 ,
Abstract
Our study estimated size of impairment for different cognitive functions in early-treated adults with PKU (AwPKU) by combining literature results in a meta-analytic way. We analysed a large set of functions (N=19), each probed by different measures (average=12). Data were extracted from 26 PKU groups and matched controls, with 757 AwPKU contributing 220 measures. Effect sizes (ESs) were computed using Glass' ∆ where differences in performance between clinical/PKU and control groups are standardized using the mean and standard deviation of the control groups. Significance was assessed using 'measures nested within independent PKU groups' as a random factor. The weighted Glass' ∆ was -.44 for all functions taken together, and -.60 for IQ, both highly significant. Separate, significant impairments were found for most functions, but with great variability (ESs from -1.02 to -.18). The most severe impairments were in reasoning, visual-spatial attention speed, sustained attention, visuo-motor control, and flexibility. Effect sizes were larger with speed than accuracy measures, and with visuo-spatial than verbal stimuli. Results show a specific PKU profile that needs consideration when monitoring the disease.
Publication DOI: | https://doi.org/10.1016/j.neubiorev.2022.104925 |
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Divisions: | College of Health & Life Sciences > School of Psychology |
Additional Information: | Copyright © 2022, The Authors. This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/). |
Uncontrolled Keywords: | PKU,Patterna of cognitive impairments,Metabolic disease,Executive functions,Memory,Language,Speed and accuracy,Verbal vs Visual |
Publication ISSN: | 1873-7528 |
Last Modified: | 07 Oct 2024 07:40 |
Date Deposited: | 10 Nov 2022 10:39 |
Full Text Link: | |
Related URLs: |
https://www.sci ... 4146?via%3Dihub
(Publisher URL) http://www.scop ... tnerID=8YFLogxK (Scopus URL) |
PURE Output Type: | Review article |
Published Date: | 2022-12 |
Published Online Date: | 2022-10-22 |
Accepted Date: | 2022-10-21 |
Authors: |
Romani, Cristina
(
0000-0002-5693-4131)
Olson, Andrew Aitkenhead, Lynne Baker, Lucy Patel, Dhanesha Spronsen, Francjan Van MacDonald, Anita Wegberg, Annemiek van Huijbregts, Stephan |