Exploring mitochondrial hydrogen sulfide signalling for therapeutic interventions in vascular diseases

Abstract

Hydrogen sulfide (H2S), a gaseous signalling molecule, is important in numerous physiological and pathophysiological processes. Despite its initial identification as an environmental toxin, H2S is now well described as an essential physiological molecule that is finely balanced to maintain cellular functions, especially in modulating mitochondrial activity. Mitochondria are responsible for the oxidation of H2S and its safe elimination while maintaining mitochondrial biogenesis. H2S oxidation in mitochondria generates various reactive sulfur species that could post-translationally modify proteins by sulfhydration. Sulfhydrated proteins participate in many regulatory activities either by direct interactions in the electron transport chain or indirect regulation by epigenetics. These investigations explain the importance of research of H2S as a therapeutic molecule beyond the traditional understanding as a protective role through its anti-inflammatory and antioxidant properties. This review focuses on highlighting the significant involvement of the H2S pathway in vascular diseases and current H2S donors for therapeutic use under development.

Publication DOI: https://doi.org/10.1016/j.arres.2022.100030
Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences > Aston Medical School > Translational Medicine Research Group (TMRG)
College of Health & Life Sciences
College of Health & Life Sciences > Aston Medical School
College of Health & Life Sciences > Chronic and Communicable Conditions
Additional Information: Crown Copyright © 2022 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Uncontrolled Keywords: Hydrogen sulfide,Mitochondria,Endothelial cells,Sulfhydration,Vascular disease,Signalling
Publication ISSN: 2667-1379
Last Modified: 28 Feb 2024 08:21
Date Deposited: 14 Sep 2022 15:04
Full Text Link:
Related URLs: https://www.sci ... 0029?via%3Dihub (Publisher URL)
PURE Output Type: Article
Published Date: 2022-04
Published Online Date: 2022-01-12
Accepted Date: 2022-01-05
Authors: Sanchez, Lorena Diaz
Sanchez-Aranguren, Lissette (ORCID Profile 0000-0002-4663-5752)
Marwah, Mandeep (ORCID Profile 0000-0003-4881-003X)
Wang, Keqing (ORCID Profile 0000-0001-6239-6344)
Spickett, Corinne M (ORCID Profile 0000-0003-4054-9279)
Griffiths, Helen R
Dias, Irundika HK (ORCID Profile 0000-0002-6620-8221)

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