Combining multi-site magnetic resonance imaging with machine learning predicts survival in pediatric brain tumors

Abstract

Brain tumors represent the highest cause of mortality in the pediatric oncological population. Diagnosis is commonly performed with magnetic resonance imaging. Survival biomarkers are challenging to identify due to the relatively low numbers of individual tumor types. 69 children with biopsy-confirmed brain tumors were recruited into this study. All participants had perfusion and diffusion weighted imaging performed at diagnosis. Imaging data were processed using conventional methods, and a Bayesian survival analysis performed. Unsupervised and supervised machine learning were performed with the survival features, to determine novel sub-groups related to survival. Sub-group analysis was undertaken to understand differences in imaging features. Survival analysis showed that a combination of diffusion and perfusion imaging were able to determine two novel sub-groups of brain tumors with different survival characteristics (p < 0.01), which were subsequently classified with high accuracy (98%) by a neural network. Analysis of high-grade tumors showed a marked difference in survival (p = 0.029) between the two clusters with high risk and low risk imaging features. This study has developed a novel model of survival for pediatric brain tumors. Tumor perfusion plays a key role in determining survival and should be considered as a high priority for future imaging protocols.

Publication DOI: https://doi.org/10.1038/s41598-021-96189-8
Divisions: College of Health & Life Sciences > School of Psychology
College of Health & Life Sciences > Aston Institute of Health & Neurodevelopment (AIHN)
College of Health & Life Sciences
Additional Information: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Funding: We would like to acknowledge funding from The CCLG and Little Princess Trust (CCLGA 2017 15) who funded Dr James Grist, Action Medical Research and the Brain Tumor Charity (GN2181), Children with Cancer (15/188), Birmingham Children’s Hospital Research Foundation, Help Harry Help Others, Poppyfields, Children’s Research Fund, Cancer Research UK and EPSRC Cancer Imaging Programme the Children’s Cancer and Leukaemia Group (CCLG) in association with the MRC and Department of Health (England) (C7809/A10342), the Cancer Research UK and NIHR Experimental Cancer Medicine Centre Paediatric Network (C8232/A25261), the Medical Research Council—Health Data Research UK Substantive Site and Help Harry Help Others charity. Professor Peet is funded through an NIHR Research Professorship, NIHR-RP-R2-12-019. Stephen Powell gratefully acknowledges financial support from EPSRC through a studentship from the Physical Sciences for Health Centre for Doctoral Training (EP/L016346/1). Theodoros Arvanitis is partially funded by the MRC (HDR UK).
Publication ISSN: 2045-2322
Last Modified: 12 Jun 2024 07:21
Date Deposited: 24 Sep 2021 08:05
Full Text Link:
Related URLs: https://www.nat ... 598-021-96189-8 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2021-09-23
Accepted Date: 2021-07-27
Submitted Date: 2021-01-04
Authors: Grist, James T.
Withey, Stephanie
Bennett, Christopher
Rose, Heather E. L.
MacPherson, Lesley
Oates, Adam
Powell, Stephen
Novak, Jan (ORCID Profile 0000-0001-5173-3608)
Abernethy, Laurence
Pizer, Barry
Bailey, Simon
Clifford, Steven C.
Mitra, Dipayan
Arvanitis, Theodoros N.
Auer, Dorothee P.
Avula, Shivaram
Grundy, Richard
Peet, Andrew C.

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