Protein Lipoxidation: Basic Concepts and Emerging Roles


Protein lipoxidation is a non-enzymatic post-translational modification that consists of the covalent addition of reactive lipid species to proteins. This occurs under basal conditions but increases in situations associated with oxidative stress. Protein targets for lipoxidation include metabolic and signalling enzymes, cytoskeletal proteins, and transcription factors, among others. There is strong evidence for the involvement of protein lipoxidation in disease, including atherosclerosis, neurodegeneration, and cancer. Nevertheless, the involvement of lipoxidation in cellular regulatory mechanisms is less understood. Here we review basic aspects of protein lipoxidation and discuss several features that could support its role in cell signalling, including its selectivity, reversibility, and possibilities for regulation at the levels of the generation and/or detoxification of reactive lipids. Moreover, given the great structural variety of electrophilic lipid species, protein lipoxidation can contribute to the generation of multiple structurally and functionally diverse protein species. Finally, the nature of the lipoxidised proteins and residues provides a frameshift for a complex interplay with other post-translational modifications, including redox and redox-regulated modifications, such as oxidative modifications and phosphorylation, thus strengthening the importance of detailed knowledge of this process.

Publication DOI:
Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences
College of Health & Life Sciences > Chronic and Communicable Conditions
Additional Information: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Uncontrolled Keywords: Cell signalling,Electrophilic lipids,Lipoxidation,Oxidative stress,Post-translational modifications,Regulation,Selectivity,Biochemistry,Physiology,Molecular Biology,Clinical Biochemistry,Cell Biology
Publication ISSN: 2076-3921
Last Modified: 23 Apr 2024 07:19
Date Deposited: 18 Feb 2021 11:56
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Related URLs: https://www.mdp ... 6-3921/10/2/295 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Review article
Published Date: 2021-02-16
Accepted Date: 2021-02-10
Authors: Viedma-Poyatos, Álvaro
González-Jiménez, Patricia
Langlois, Ophélie
Company-Marín, Idoia
Spickett, Corinne M. (ORCID Profile 0000-0003-4054-9279)
Pérez-Sala, Dolores



Version: Published Version

License: Creative Commons Attribution

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