Poly(butylene succinate) fibrous dressings containing natural antimicrobial agents

Abstract

Poly(butylene succinate) (PBSU) is a biodegradable and biocompatible synthetic aliphatic polyester, which has been used extensively in packaging, catering and agriculture, and more recently in drug delivery and bone and cartilage repair. PBSU-based mats created by electrospinning show promise as wound dressing materials because of their good mechanical properties, high surface area-to-volume ratio and increased levels of porosity. In this work, we present the creation of antimicrobial PBSU fibrous mats through the incorporation of natural food grade agents via blend electrospinning. Three types of edible gums (namely arabic, karaya and tragacanth), two essential oils (coriander and lavender), and one free fatty acid (linoleic acid) were added to PBSU containing a chain extender and their effect on six clinically relevant pathogens was evaluated. Mats containing essential oils at the highest concentration studied (7% w/v) showed some antimicrobial behaviour against S. aureus, E. hirae and P. aeruginosa, whereas the incorporation of linoleic acid at both concentrations tested (3% and 5% w/v) gave a strong reaction against S. pyogenes. Gum arabic was the only gum that had a considerable impact on S. aureus. Furthermore, the three gums enhanced the mechanical properties of the polymer mats and brought them closer to those of the human skin, whilst all agents maintained the high biocompatibility of the PBSU mats when contacted with mouse fibroblasts. This work, for the first time, shows the great promise of PBSU blended fibres as a skin substitute and paves the way towards bioactive and cost effective wound dressings from renewable materials.

Publication DOI: https://doi.org/10.1177/1528083720987209
Divisions: College of Engineering & Physical Sciences > Chemical Engineering & Applied Chemistry
College of Engineering & Physical Sciences > Mechanical Engineering & Design
College of Engineering & Physical Sciences > Aston Institute of Urban Technology and the Environment (ASTUTE)
College of Engineering & Physical Sciences > Aston Institute of Materials Research (AIMR)
College of Engineering & Physical Sciences
College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences > Chronic and Communicable Conditions
College of Health & Life Sciences
Additional Information: This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). Funding: This work was supported by the UK Engineering and Physical Sciences Research Council: Bridging the Gaps between Engineering and Physical Sciences in Antimicrobial Resistance as part of the UK Cross-Research Council Initiative on Antimicrobial Resistance Grant No. EP/M02735X/1.
Uncontrolled Keywords: Electrospinning,fibrous antimicrobial wound dressings,food grade additives,poly(butylene succinate) nanofibers,Chemical Engineering (miscellaneous),Materials Science (miscellaneous),Polymers and Plastics,Industrial and Manufacturing Engineering
Full Text Link:
Related URLs: https://journal ... 528083720987209 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2021-01-12
Published Online Date: 2021-01-12
Accepted Date: 2020-12-17
Authors: Aliko, Kinana
Aldakhlalla, Mohamad
Leslie, Laura (ORCID Profile 0000-0002-7925-9589)
Worthington, Tony (ORCID Profile 0000-0002-1906-3357)
Topham, Paul (ORCID Profile 0000-0003-4152-6976)
Theodosiou, Eirini (ORCID Profile 0000-0001-7068-4434)

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