Neurodevelopmental outcomes in paediatric immune-mediated and autoimmune epileptic encephalopathy


Recognition of paediatric autoimmune/immune-mediated encephalitis and epileptic encephalopathy (e.g. NMDAR-Ab encephalitis) has rapidly increased over the last ten years. While we are succeeding in the diagnosis and identification and even early treatment of these encephalitidies, with studies describing >80% are making a “good” recovery, we are now recognising that a “good” medical outcome does not cover the cognitive, social and behavioural sequelae that can occur, particularly in paediatric patients. Basic measures of medical outcome, for example the modified Rankin Scale (MRS) or the Paediatric Cerebral Performance Category (PCPC), offer the advantage of being quick to use, but do not reveal the more complex difficulties that can impact the future of affected children. This article reviews the current literature on neurodevelopmental outcomes in children affected with autoimmune and immune-mediated encephalitis/epileptic encephalopathy and provides guidance on post-onset surveillance aimed at identifying those most likely to experience ongoing long-term difficulties.

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Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences
College of Health & Life Sciences > School of Psychology
Additional Information: © 2019, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Funding: European Research Council Consolidator Fellowship (ERC-CoG2015-PROBIt-682734). Epilepsy Research UK Postdoctoral Fellowship (F1601) and a Wellcome Trust Clinical Research Career Development Fellowship (216613/Z/19/Z).
Uncontrolled Keywords: ADEM,Autoimmune encephalitis,Cognition/behaviour,MOG antibodies,Neurodevelopmental outcomes,Paediatric NMDAR-Ab encephalitis,Pediatrics, Perinatology, and Child Health,Clinical Neurology
Publication ISSN: 1090-3798
Last Modified: 15 Jan 2024 08:23
Date Deposited: 08 Jan 2020 11:29
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Related URLs: https://linking ... 090379819304301 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Review article
Published Date: 2020-01-01
Published Online Date: 2019-12-20
Accepted Date: 2019-12-06
Authors: Wright, Sukhvir K. (ORCID Profile 0000-0002-5464-3779)
Wood, Amanda G. (ORCID Profile 0000-0002-1537-6858)

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