Allocation of rhodamine-loaded nanocapsules from blood circulatory system to adjacent tissues assessed in vivo by fluorescence spectroscopy

Abstract

Modern fluorescent modalities play an important role in the functional diagnostic of various physiological processes in living tissues. Utilizing the fluorescence spectroscopy approach we observe the circulation of fluorescent-labelled nanocapsules with rhodamine tetramethylrhodamine in a microcirculatory blood system. The measurements were conducted transcutaneously on the surface of healthy Wistar rat thighs in vivo. The administration of the preparation capsule suspension with a rhodamine concentration of 5 mg kg−1 of the animal weight resulted in a two-fold increase of fluorescence intensity relative to the baseline level. The dissemination of nanocapsules in the adjacent tissues via the circulatory system was observed and assessed quantitatively. The approach can be used for the transdermal assessment of rhodamine-loaded capsules in vivo.

Publication DOI: https://doi.org/10.1088/1612-202X/aad857
Divisions: College of Engineering & Physical Sciences
College of Engineering & Physical Sciences > Aston Institute of Photonics Technology (AIPT)
Additional Information: ©2018 IOP Publishing Ltd.
Publication ISSN: 1612-202X
Last Modified: 06 May 2024 07:25
Date Deposited: 31 Aug 2018 07:24
Full Text Link:
Related URLs: http://iopscien ... 02X/aad857/meta (Publisher URL)
PURE Output Type: Article
Published Date: 2018-10-01
Published Online Date: 2018-08-21
Accepted Date: 2018-08-03
Authors: Tarakanchikova, Yana
Stelmashchuk, Olga
Seryogina, Evgeniya
Piavchenko, Gennadii
Zherebtsov, Evgeny (ORCID Profile 0000-0002-3635-1430)
Dunaev, Andrey
Popov, Alexey
Meglinski, Igor

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