Romani, Cristina, MacDonald, Anita, de Felice, Sara and Palermo, Liana (2018). Speed of processing and executive functions in adults with phenylketonuria:quick in finding the word, but not the ladybird. Cognitive Neuropsychology, 35 (3-4), pp. 171-198.
Abstract
A reduction in processing speed is widely reported in phenylketonuria (PKU), possibly due to white matter pathology. We investigated possible deficits and their relationships with executive functions in a sample of 37 early-treated adults with PKU (AwPKUs). AwPKUs were not characterized by a generalized speed deficit, but instead their performance could be explained by two more specific impairments: (a) a deficit in the allocation of visuo-spatial attention that reduced speed in visual search tasks, in some reading conditions and visuo-motor coordination tasks; and (b) a more conservative decision mechanism that slowed down returning an answer across domains. These results suggest that the impairments in executive functions seen in AwPKUs are not the consequence of a generalized speed deficit. They also suggest that processing speed is linked to the efficiency of a particular cognitive component and cannot be considered a general function spanning domains. Similarities with patterns in ageing are discussed.
Publication DOI: | https://doi.org/10.1080/02643294.2017.1320278 |
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Divisions: | College of Health & Life Sciences > School of Psychology College of Health & Life Sciences > Clinical and Systems Neuroscience College of Health & Life Sciences College of Health & Life Sciences > School of Optometry > Vision, Hearing and Language |
Additional Information: | This is an Accepted Manuscript of an article published by Taylor & Francis in Cognitive Neuropsychology on 20/6/17, available online: http://www.tandfonline.com/10.1080/02643294.2017.1320278 |
Uncontrolled Keywords: | ageing,executive functions,feature vs. conjunction search,Phenylketonuria,serial vs. parallel search,speed of processing,Neuropsychology and Physiological Psychology,General Medicine,Experimental and Cognitive Psychology,Developmental and Educational Psychology,Arts and Humanities (miscellaneous),Cognitive Neuroscience |
Publication ISSN: | 1464-0627 |
Last Modified: | 03 Oct 2024 07:15 |
Date Deposited: | 27 Jul 2017 12:35 |
Full Text Link: | |
Related URLs: |
http://www.scop ... tnerID=8YFLogxK
(Scopus URL) |
PURE Output Type: | Article |
Published Date: | 2018-05-19 |
Published Online Date: | 2017-06-20 |
Accepted Date: | 2017-04-10 |
Submitted Date: | 2016-09-28 |
Authors: |
Romani, Cristina
(
0000-0002-5693-4131)
MacDonald, Anita de Felice, Sara Palermo, Liana ( 0000-0001-8047-7201) |