Routledge, Sarah J., Ladds, Graham and Poyner, David R. (2017). The effects of RAMPs upon cell signalling. Molecular and Cellular Endocrinology, 449 , pp. 12-20.
Abstract
G protein-coupled receptors (GPCRs) play a vital role in signal transduction. It is now clear that numerous other molecules within the cell and at the cell surface interact with GPCRs to modulate their signalling properties. Receptor activity modifying proteins (RAMPs) are a group of single transmembrane domain proteins which have been predominantly demonstrated to interact with Family B GPCRs, but interactions with Family A and C receptors have recently begun to emerge. These interactions can influence cell surface expression, ligand binding preferences and G protein-coupling, thus modulating GPCR signal transduction. There is still a great deal of research to be conducted into the effects of RAMPs on GPCR signalling; their effects upon Family B GPCRs are still not fully documented, in addition to their potential interactions with Family A and C GPCRs. New interactions could have a significant impact on the development of therapeutics.
Publication DOI: | https://doi.org/10.1016/j.mce.2017.03.033 |
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Divisions: | College of Health & Life Sciences > School of Biosciences College of Health & Life Sciences > Aston Pharmacy School College of Health & Life Sciences College of Health & Life Sciences > Chronic and Communicable Conditions College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine Aston University (General) |
Additional Information: | © 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ Funding: BBSRC grants BB/M00015X/1 and BB/M000176/1. |
Uncontrolled Keywords: | receptor activity modifying protein 1, G protein-coupled receptor,signalling,trafficking,coupling,Biochemistry,Molecular Biology,Endocrinology |
Last Modified: | 14 Oct 2024 12:01 |
Date Deposited: | 02 May 2017 14:45 |
Full Text Link: | |
Related URLs: |
http://www.scop ... tnerID=8YFLogxK
(Scopus URL) |
PURE Output Type: | Article |
Published Date: | 2017-07-05 |
Published Online Date: | 2017-04-05 |
Accepted Date: | 2017-03-24 |
Submitted Date: | 2016-07-29 |
Authors: |
Routledge, Sarah J.
Ladds, Graham Poyner, David R. ( 0000-0003-1590-112X) |
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Version: Accepted Version
License: Creative Commons Attribution Non-commercial No Derivatives
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