The effects of RAMPs upon cell signalling

Abstract

G protein-coupled receptors (GPCRs) play a vital role in signal transduction. It is now clear that numerous other molecules within the cell and at the cell surface interact with GPCRs to modulate their signalling properties. Receptor activity modifying proteins (RAMPs) are a group of single transmembrane domain proteins which have been predominantly demonstrated to interact with Family B GPCRs, but interactions with Family A and C receptors have recently begun to emerge. These interactions can influence cell surface expression, ligand binding preferences and G protein-coupling, thus modulating GPCR signal transduction. There is still a great deal of research to be conducted into the effects of RAMPs on GPCR signalling; their effects upon Family B GPCRs are still not fully documented, in addition to their potential interactions with Family A and C GPCRs. New interactions could have a significant impact on the development of therapeutics.

Publication DOI: https://doi.org/10.1016/j.mce.2017.03.033
Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences
College of Health & Life Sciences > Chronic and Communicable Conditions
College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine
Additional Information: © 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ Funding: BBSRC grants BB/M00015X/1 and BB/M000176/1.
Uncontrolled Keywords: receptor activity modifying protein 1, G protein-coupled receptor,signalling,trafficking,coupling,Biochemistry,Molecular Biology,Endocrinology
Full Text Link:
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2017-04-05
Published Online Date: 2017-04-05
Accepted Date: 2017-03-24
Submitted Date: 2016-07-29
Authors: Routledge, Sarah J.
Ladds, Graham
Poyner, David R. (ORCID Profile 0000-0003-1590-112X)

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