Scerri, Thomas S., Darki, Fahimeh, Newbury, Dianne F., Whitehouse, Andrew J.O., Peyrard-Janvid, Myriam, Matsson, Hans, Ang, Qi W., Pennell, Craig E., Ring, Susan, Stein, John, Morris, Andrew P., Monaco, Anthony P., Kere, Juha, Talcott, Joel, Klingberg, Torkel and Paracchini, Silvia (2012). The dyslexia candidate locus on 2p12 is associated with general cognitive ability and white matter structure. PLoS ONE, 7 (11),
Abstract
Independent studies have shown that candidate genes for dyslexia and specific language impairment (SLI) impact upon reading/language-specific traits in the general population. To further explore the effect of disorder-associated genes on cognitive functions, we investigated whether they play a role in broader cognitive traits. We tested a panel of dyslexia and SLI genetic risk factors for association with two measures of general cognitive abilities, or IQ, (verbal and non-verbal) in the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort (N>5,000). Only the MRPL19/C2ORF3 locus showed statistically significant association (minimum P = 0.00009) which was further supported by independent replications following analysis in four other cohorts. In addition, a fifth independent sample showed association between the MRPL19/C2ORF3 locus and white matter structure in the posterior part of the corpus callosum and cingulum, connecting large parts of the cortex in the parietal, occipital and temporal lobes. These findings suggest that this locus, originally identified as being associated with dyslexia, is likely to harbour genetic variants associated with general cognitive abilities by influencing white matter structure in localised neuronal regions.
Publication DOI: | https://doi.org/10.1371/journal.pone.0050321 |
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Divisions: | College of Health & Life Sciences > School of Psychology College of Health & Life Sciences > Clinical and Systems Neuroscience College of Health & Life Sciences > Aston Institute of Health & Neurodevelopment (AIHN) College of Health & Life Sciences > School of Optometry > Vision, Hearing and Language |
Additional Information: | © 2012 Scerri et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
Uncontrolled Keywords: | General Agricultural and Biological Sciences,General Biochemistry,Genetics and Molecular Biology,General Medicine |
Publication ISSN: | 1932-6203 |
Last Modified: | 30 Sep 2024 10:09 |
Date Deposited: | 04 Jan 2013 10:33 |
Full Text Link: |
http://www.plos ... al.pone.0050321 |
Related URLs: |
http://www.scop ... tnerID=8YFLogxK
(Scopus URL) |
PURE Output Type: | Article |
Published Date: | 2012-11-28 |
Authors: |
Scerri, Thomas S.
Darki, Fahimeh Newbury, Dianne F. Whitehouse, Andrew J.O. Peyrard-Janvid, Myriam Matsson, Hans Ang, Qi W. Pennell, Craig E. Ring, Susan Stein, John Morris, Andrew P. Monaco, Anthony P. Kere, Juha Talcott, Joel ( 0000-0001-7958-8369) Klingberg, Torkel Paracchini, Silvia |