Reis, Ana, Araújo, Ana Rita D, Dias, Irundika Hk, Antonny, Bruno, Perez, Antonio, Sánchez-Quesada, Jose Luis and de Freitas, Victor (2026). Effect of type-2 diabetes on surface lipids and biophysical properties in lipoprotein populations. Archives of Biochemistry and Biophysics, 779 ,
Abstract
Surface lipids in lipoproteins interact with proteins and receptors at the surface of cell membranes, mediating lipoprotein-cell signaling and trafficking events. Despite this, little is known about lipoproteins' surface lipid composition and any changes introduced by type-2 diabetes mellitus (T2DM). Herein, we investigate the surface lipid composition in purified VLDL, LDL and HDL populations isolated from patients with poor (PC, HbA1c>8.5%) and good glycemic control (GC, HbA1c
| Publication DOI: | https://doi.org/10.1016/j.abb.2026.110780 |
|---|---|
| Divisions: | College of Health & Life Sciences > Aston Medical School College of Health & Life Sciences College of Health & Life Sciences > Aston Medical School > Translational Medicine Research Group (TMRG) |
| Funding Information: | I.H.K. Dias acknowledges funding from Diabetes UK (grant number 22/0006432). |
| Additional Information: | © 2026 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) |
| Uncontrolled Keywords: | Anisotropy,Mass spectrometry,Glucosyl-ceramides,Zeta-potential,HPTLC,Cholesterol sulfate |
| Publication ISSN: | 1096-0384 |
| Last Modified: | 26 Mar 2026 17:20 |
| Date Deposited: | 19 Mar 2026 11:25 |
| Full Text Link: | |
| Related URLs: |
https://www.sci ... 0512?via%3Dihub
(Publisher URL) https://www.sco ... ns/105031657127 (Scopus URL) |
PURE Output Type: | Article |
| Published Date: | 2026-05 |
| Published Online Date: | 2026-03-02 |
| Accepted Date: | 2026-03-01 |
| Authors: |
Reis, Ana
Araújo, Ana Rita D Dias, Irundika Hk ( 
0000-0002-6620-8221)
Antonny, Bruno Perez, Antonio Sánchez-Quesada, Jose Luis de Freitas, Victor |
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