Rajabally, Zeinab, Spencer, Lydia, Mistry, Niraj and Rajabally, Yusuf A. (2025). Epidemiology, presentation, management and outcomes in chronic inflammatory demyelinating polyneuropathy in Birmingham, UK: the impact of ethnicity. Journal of the Peripheral Nervous System, 30 (4),
Abstract
Background Whether ethnicity impacts on epidemiology, presentation, management, and outcome is unknown in chronic inflammatory demyelinating polyneuropathy (CIDP). Methods We studied the prevalence/incidence of CIDP in Asian (Indian/Pakistani/Bangladeshi) and white subjects in Birmingham, UK, and associations of ethnicity with demographics/deprivation/phenotype/treatment and outcomes. Results On 10th July 2025, CIDP prevalence was 6.18 per 100 000 (95% CI: 4.66–8.05). Prevalence was lower in Asian (Indian/Pakistani/Bangladeshi) compared to white subjects (2.64 per 100 000 vs. 10.15 per 100 000; RR: 0.260, 95% CI: 0.111–0.609; p < 0.001). Prevalence in ≥ 50-year-olds was lower in Asian (Indian/Pakistani/Bangladeshi) compared to white subjects (8.00 per 100 000 vs. 46.68 per 100 000; RR: 0.172; 95% CI: 0.061–0.479; p < 0.001) but similar in 18–49-year-olds (2.48 per 100 000 vs. 1.83 per 100 000; RR: 1.355, 95% CI: 0.273–6.712; p = 0.661). Mean incidence of CIDP was 0.54 per 100 000 per year (95% CI: 0.404–0.713). CIDP incidence was lower in Asian (Indian/Pakistani/Bangladeshi) than in white subjects (0.24 per 100 000 per year vs. 0.86 per 100 000 per year, RR: 0.278; 95% CI: 0.118–0.654; p = 0.002). Asian (Indian/Pakistani/Bangladeshi) ethnicity was independently associated with younger age (p = 0.037), greater social deprivation (p = 0.045), and noncompliance to treatment (p = 0.016). No association of Asian (Indian/Pakistani/Bangladeshi) ethnicity was found with CIDP sub-type, diagnostic delay, pretreatment disability, access to high-cost therapies, or posttreatment outcomes. Conclusions Subjects of Asian (Indian/Pakistani/Bangladeshi) ethnicity in the UK may have a lower risk of CIDP after 50 years of age, but an equivalent risk between 18 and 49 years, compared to white subjects. They may present younger, be more socially deprived, and be more likely noncompliant to treatment, compared to white subjects.
Publication DOI: | https://doi.org/10.1111/jns.70065 |
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Divisions: | College of Health & Life Sciences |
Additional Information: | Copyright © 2025 The Author(s). Journal of the Peripheral Nervous System published by Wiley Periodicals LLC on behalf of Peripheral Nerve Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Publication ISSN: | 1529-8027 |
Last Modified: | 07 Oct 2025 07:21 |
Date Deposited: | 30 Sep 2025 11:14 |
Full Text Link: | |
Related URLs: |
https://onlinel ... .1111/jns.70065
(Publisher URL) |
PURE Output Type: | Article |
Published Date: | 2025-12 |
Published Online Date: | 2025-09-29 |
Accepted Date: | 2025-09-19 |
Authors: |
Rajabally, Zeinab
Spencer, Lydia Mistry, Niraj Rajabally, Yusuf A. ( ![]() |