Association between sleep duration and obesity in patients with type 2 diabetes: A longitudinal study

Abstract

Background: Obesity is prevalent in patients with type 2 diabetes (T2D) and negatively impacts diabetes outcomes. While studies in the general population have established a link between sleep duration and obesity, this relationship in T2D remains unclear. Objectives: To assess the association between sleep duration and adiposity in patients with T2D. Methods: This prospective study of adults enrolled in the SLEEP T2D study from 13 UK NHS Trusts. Sleep duration was self‐reported using the Pittsburgh Sleep Quality Index (PSQI) and categorized as short (≤ 6 h/ night), long (> 9 h/night) or (normal > 6‐9 h/night). Adiposity was assessed using body mass index (BMI) and waist circumference. Results: Among 229 patients (61% male, mean age 61.2 ( ± $$ \pm $$ 11.7) years, 63.7% with BMI ≥ 30 kg/m2). At baseline, sleep duration negatively correlated with BMI (r = −0.27, p < 0.001) and waist circumference (r = −0.25, p = 0.001). After adjusting for potential confounders in different models, short sleep duration was associated with higher BMI (β = −1.01; p = 0.006) and waist circumference (β = −1.91; p = 0.01). Following a median follow‐up of 26.5 months, short sleep at baseline was associated with a 5% or more gain in BMI (adjusted OR 10.03; 95% CI 1.55–64.84; p = 0.01). Conclusion: Short sleep duration is associated with higher adiposity measures (BMI and waist circumference) and weight gain in patients with T2D. Addressing sleep duration may reduce the burden of obesity in T2D, and future studies in this area are warranted.

Publication DOI: https://doi.org/10.1111/dme.70051
Divisions: College of Health & Life Sciences > School of Biosciences
College of Health & Life Sciences
Funding Information: This project was funded as part of National Institue for Health Research (NIHR), Clinician Scientist Award (CS-2013-13-029).
Additional Information: Copyright © 2025 The Author(s). Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords: sleep duration,body mass index,waist circumference,type 2 diabetes
Publication ISSN: 1464-5491
Last Modified: 01 May 2025 08:43
Date Deposited: 23 Apr 2025 13:28
Full Text Link:
Related URLs: https://onlinel ... .1111/dme.70051 (Publisher URL)
PURE Output Type: Article
Published Date: 2025-04-17
Published Online Date: 2025-04-17
Accepted Date: 2025-04-03
Submitted Date: 2024-11-09
Authors: Makhdom, Esraa A.
Maher, Alisha
Ottridge, Ryan
Nicholls, Mathew
Ali, Asad
Cooper, Brendan G.
Ajjan, Ramzi A.
Bellary, Srikanth (ORCID Profile 0000-0002-5924-5278)
Hanif, Wasim
Hanna, Fahmy
Hughes, David
Jayagopal, Vijay
Mahto, Rajni
Patel, Mayank
Young, James
Nayak, Ananth U.
Chen, Mimi Z.
Kyaw‐Tun, Julie
Gonzalez, Susana
Gouni, Ravikanth
Subramanian, Anuradhaa
Adderley, Nicola J.
Tahrani, Abd A.

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License: Creative Commons Attribution


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