An expert consensus statement on biomarkers of ageing for use in intervention studies

Abstract

Biomarkers of ageing serve as important outcome measures in longevity-promoting interventions. However, there is limited consensus on which specific biomarkers are most appropriate for human intervention studies. This work aimed to address this need by establishing an expert consensus on biomarkers of ageing for use in intervention studies via the Delphi method. A three-round Delphi study was conducted using an online platform. In Round 1, expert panel members provided suggestions for candidate biomarkers of ageing. In Rounds 2 and 3, they voted on 500 initial statements (yes/no) relating to 20 biomarkers of ageing. Panel members could abstain from voting on biomarkers outside their expertise. Consensus was reached when there was ≥70% agreement on a statement/biomarker. Of the 460 international panel members invited to participate, 116 completed Round 1, 87 completed Round 2, and 60 completed Round 3. Across the 3 rounds, 14 biomarkers met consensus that spanned physiological (e.g., insulin-like growth factor 1, growth-differentiating factor-15), inflammatory (e.g., high sensitivity c-reactive protein, interleukin-6), functional (e.g., muscle mass, muscle strength, hand grip strength, Timed-Up-and-Go, gait speed, standing balance test, frailty index, cognitive health, blood pressure), and epigenetic (e.g., DNA methylation/epigenetic clocks) domains. Expert consensus identified 14 potential biomarkers of ageing which may be used as outcome measures in intervention studies. Future ageing research should identify which combination of these biomarkers has the greatest utility.

Publication DOI: https://doi.org/10.1093/gerona/glae297
Divisions: College of Health & Life Sciences > Aston Medical School
College of Health & Life Sciences
Aston University (General)
Additional Information: Copyright © The Author(s) 2024. Published by Oxford University Press on behalf of the Gerontological Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Publication ISSN: 1758-535X
Last Modified: 13 Mar 2025 08:11
Date Deposited: 15 Jan 2025 10:48
Full Text Link:
Related URLs: https://academi ... google_vignette (Publisher URL)
PURE Output Type: Article
Published Date: 2024-12-21
Published Online Date: 2024-12-21
Accepted Date: 2024-12-01
Authors: Perri, Giorgia
French, Chloe
Agostinis-Sobrinho, César
Anand, Atul
Antarianto, Radiana Dhewayani
Arai, Yasumichi
Baur, Joseph A
Cauli, Omar
Clivaz-Duc, Morgane
Colloca, Giuseppe
Demetriades, Constantinos
de Lucia, Chiara
Di Gessa, Giorgio
Diniz, Breno S
Dotchin, Catherine L
Eaglestone, Gillian
Elliott, Bradley T
Espeland, Mark A
Ferrucci, Luigi
Fisher, James
Grammatopoulos, Dimitris K
Hardiany, Novi S
Hassan-Smith, Zaki (ORCID Profile 0000-0002-8387-3039)
Hastings, Waylon J
Jain, Swati
Joshi, Peter K
Katsila, Theodora
Kemp, Graham J
Khaiyat, Omid A
Lamming, Dudley W
Gallegos, Jose Lara
Madeo, Frank
Maier, Andrea B
Martin-Ruiz, Carmen
Martins, Ian J
Mathers, John C
Mattin, Lewis R
Merchant, Reshma A
Moskalev, Alexey
Neytchev, Ognian
Ni Lochlainn, Mary
Owen, Claire M
Phillips, Stuart M
Pratt, Jedd
Prokopidis, Konstantinos
Rattray, Nicholas J W
Rúa-Alonso, María
Schomburg, Lutz
Scott, David
Shyam, Sangeetha
Sillanpää, Elina
Tan, Michelle M C
Teh, Ruth
Tobin, Stephanie W
Vila-Chã, Carolina J
Vorluni, Luigi
Weber, Daniela
Welch, Ailsa
Wilson, Daisy
Wilson, Thomas
Zhao, Tongbiao
Philippou, Elena
Korolchuk, Viktor I
Shannon, Oliver M

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