Wolffsohn, James S. and Gifford, Kate L. (2025). Optical strategy utilising contrast modulation to slow myopia. Ophthalmology Science, 5 (4),
Abstract
A new method to slow myopia progression utilises Diffusion Optics Technology™ (DOT) spectacle lenses. The proposed mechanism of action for the DOT lenses is to modulate contrast across the photoreceptor cells, leading to an altered activity of the ON and OFF pathways and slowing the progression of axial elongation. This approach is different to the current optical approaches that utilise optical defocus to reduce hyperopic defocus at the peripheral retina while central vision is fully corrected to slow myopia. Initial clinical studies with the DOT lenses have demonstrated promising results with a reduction in progression of myopia. This overview summarises the current knowledge on myopia risk factors, the evidence for involvement of contrast signalling pathways in refractive error development, and the theories and mechanisms behind DOT lens technology. It also considers the role for contrast and the paradoxical observations given the established paradigm of form deprivation in animal models.
Publication DOI: | https://doi.org/10.1016/j.xops.2024.100672 |
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Divisions: | College of Health & Life Sciences > School of Optometry > Optometry & Vision Science Research Group (OVSRG) College of Health & Life Sciences > School of Optometry > Optometry College of Health & Life Sciences Aston University (General) |
Funding Information: | The review was facilitated by SightGlass Vision. Support for Open Access publication was provided by SightGlass Vision. |
Additional Information: | Copyright © 2024 by the American Academy of Ophthalmologyé. This is an open access article distributed under the terms of the Creative Commons CC-BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Last Modified: | 05 May 2025 07:26 |
Date Deposited: | 16 Dec 2024 14:50 |
Full Text Link: | |
Related URLs: |
https://www.sci ... 2082?via%3Dihub
(Publisher URL) |
PURE Output Type: | Article |
Published Date: | 2025-07 |
Published Online Date: | 2024-12-09 |
Accepted Date: | 2024-12-03 |
Authors: |
Wolffsohn, James S.
(![]() Gifford, Kate L. |