Baker, Emily, J., Allcott, Gemma and Cox, Jonathan A. G. (2024). Polymicrobial infection in cystic fibrosis and future perspectives for improving Mycobacterium abscessus drug discovery. npj Antimicrobials and Resistance, 2 (1),
Abstract
Polymicrobial communities inhabit the cystic fibrosis (CF) airway, whereby microbial interactions can occur. One prominent CF pathogen is Mycobacterium abscessus, whose treatment is largely unsuccessful. This creates a need to discover novel antimicrobial agents to treat M. abscessus, however the methods used within antibiotic discovery are typically monomicrobial. This review will discuss this pathogen whilst considering the CF polymicrobial environment, to highlight future perspectives to improve M. abscessus drug discovery.
| Publication DOI: | https://doi.org/10.1038/s44259-024-00060-5 |
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| Divisions: | College of Health & Life Sciences > School of Biosciences |
| Funding Information: | This research was funded by the Engineering and Physical Sciences Research Council (EPSRC) and Science Foundation Ireland (SFI) Centre for Doctoral Training in Engineered Tissues for Discovery, Industry and Medicine [EP/S02347X/1]. EJB is supported by a P |
| Additional Information: | Copyright © The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/ |
| Publication ISSN: | 2731-8745 |
| Last Modified: | 22 Apr 2025 07:18 |
| Date Deposited: | 04 Dec 2024 08:21 |
| Full Text Link: | |
| Related URLs: |
https://www.nat ... 259-024-00060-5
(Publisher URL) |
PURE Output Type: | Review article |
| Published Date: | 2024-11-14 |
| Published Online Date: | 2024-11-14 |
| Accepted Date: | 2024-11-03 |
| Submitted Date: | 2024-07-09 |
| Authors: |
Baker, Emily, J.
Allcott, Gemma Cox, Jonathan A. G. ( 
0000-0001-5208-4056)
|