Effects of 1267 nm illumination on microcirculation regulatory mechanisms

Abstract

This study explored the effects of 1267 nm laser irradiation on changes in blood flow parameters and activation of the regulatory mechanisms of the microcirculatory bed (MCB). Using laser Doppler flowmetry (LDF) technique and time-frequency analysis of perfusion signals, changes in the MCB of 16 healthy volunteers, targeting the distal phalanx of the third finger with 1267 nm laser irradiation were evaluated. Results indicated no significant differences in perfusion between control and target measurements, likely due to blood flow redistribution caused by vessel dilation/constriction. However, differences in oscillation amplitudes in endothelial and myogenic ranges were observed, suggesting microcirculation self-regulation. Detailed analysis revealed characteristic peaks in the endothelial range during and after irradiation, indicating endothelial mediator release. It is assumed that the identified effects may be related to the singlet oxygen generated by 1267 nm laser irradiation, which directly affects the MCB, manifesting as endothelium-dependent vascular activity.

Publication DOI: https://doi.org/10.1002/jbio.202400296
Divisions: College of Engineering & Physical Sciences > Aston Institute of Photonics Technology (AIPT)
College of Engineering & Physical Sciences
Aston University (General)
Funding Information: This work was supported by Russian Science Foundation under the project No. 21-75-00086.
Additional Information: Copyright © 2024 The Author(s). Journal of Biophotonics published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords: 1267 nm laser,blood flow oscillation,laser Doppler flowmetry,microcirculatory bed,singlet oxygen,wavelet analysis,General Chemistry,General Materials Science,General Biochemistry,Genetics and Molecular Biology,General Engineering,General Physics and Astronomy
Publication ISSN: 1864-0648
Data Access Statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Last Modified: 27 Mar 2025 08:11
Date Deposited: 03 Dec 2024 16:09
Full Text Link:
Related URLs: https://onlinel ... /jbio.202400296 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2024-11-26
Published Online Date: 2024-11-26
Accepted Date: 2024-11-15
Authors: Eratova, Lyubov
Makovik, Irina
Dremin, Viktor (ORCID Profile 0000-0001-6974-3505)

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