Effect of Heating and Massaging of Meibomian Glands on Their Imaging

Abstract

Background and Objectives: Infrared light is used to image the Meibomian glands through their thermal profile. This study aimed to investigate the effects of a combination of heating and an eyelid massage on Meibomian gland visibility and tear film parameters. Materials and Methods: Twenty-four participants (26 ± 6.9 years) were enrolled in this prospective study, which involved imaging the Meibomian glands of both the lower and upper eyelid and assessing the non-invasive breakup time (NIBUT), tear meniscus height (TMH), and blink rate (using the CA-800, Topcon) at baseline after five minutes of eyelid warming followed by a five-minute eyelid massage. The second session, which was randomised in sequence, repeated the same measurements but without the inclusion of any eyelid warming or massage as the control condition. Results: While there was no change in lower lid Meibomian gland appearance as a result of eyelid heating, eyelid massage, or multiple lid eversion (median 2.0, range 0.0 to 4.0; p = 0.782), there was a change in upper lid appearance 5 min after heating and lid massage ( p = 0.025), but again, multiple lid eversion had no effect ( p > 0.05). The NIBUT decreased on second lid eversion ( p = 0.049), although this was not evident on the third lid eversion ( p = 0.090). The effect on NIBUT was also apparent with heating ( p = 0.034 immediately after) but was sustained with 5 min of eyelid massage ( p = 0.031). The TMH increased with heating ( p < 0.001), and this effect was sustained with 5 min of eyelid massage ( p = 0.011), but there was no lid eversion effect ( p > 0.05). The blink rate was unaffected by heating, eyelid massage, or multiple eversions of the eyelids (median 24 blinks/min, range 8 to 59 blinks/min; p = 0.61). Conclusions: Eyelid warming can increase the visibility of the Meibomian glands, although this effect was only observed with upper lid imaging and the effect dissipated after 5 min of eyelid massage. Warming and massage also disrupt the tear film, as does multiple lid eversion, emphasising the need to use the least invasive tear film assessment techniques first.

Publication DOI: https://doi.org/10.3390/medicina60101603
Divisions: College of Health & Life Sciences
College of Health & Life Sciences > School of Optometry > Optometry & Vision Science Research Group (OVSRG)
College of Health & Life Sciences > School of Optometry > Optometry
College of Health & Life Sciences > School of Optometry
Aston University (General)
Additional Information: Copyright © 2024 by the authors. Published by MDPI on behalf of the Lithuanian University of Health Sciences. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Uncontrolled Keywords: Meibomiam glands,dry eye,tear film,heating,eyelid massage,General Medicine
Publication ISSN: 1648-9144
Data Access Statement: The research data were not all shared within the article; however they may be made available upon request.
Last Modified: 19 Nov 2024 17:25
Date Deposited: 29 Oct 2024 17:03
Full Text Link:
Related URLs: https://www.mdp ... 9144/60/10/1603 (Publisher URL)
PURE Output Type: Article
Published Date: 2024-10
Published Online Date: 2024-09-29
Accepted Date: 2024-09-20
Authors: Pettayil, Justin E.
Haque, Samya
Fardin, Mohammed
Dhallu, Sandeep Kaur
Travé-Huarte, Sònia
Wolffsohn, James S. (ORCID Profile 0000-0003-4673-8927)
Dutta, Debarun (ORCID Profile 0000-0002-2204-5272)

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