International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents

Abstract

Phaeochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumours that arise not only in adulthood but also in childhood and adolescence. Up to 70–80% of childhood PPGL are hereditary, accounting for a higher incidence of metastatic and/or multifocal PPGL in paediatric patients than in adult patients. Key differences in the tumour biology and management, together with rare disease incidence and therapeutic challenges in paediatric compared with adult patients, mandate close expert cross-disciplinary teamwork. Teams should ideally include adult and paediatric endocrinologists, oncologists, cardiologists, surgeons, geneticists, pathologists, radiologists, clinical psychologists and nuclear medicine physicians. Provision of an international Consensus Statement should improve care and outcomes for children and adolescents with these tumours.

Publication DOI: https://doi.org/10.1038/s41574-024-01024-5
Divisions: College of Health & Life Sciences > Aston Medical School
Additional Information: Copyright © Crown 2024, corrected publication 2024. This is an accepted manuscript of an article published in Nature Reviews Endocrinology. The published version is available at: https://doi.org/10.1038/s41574-024-01024-5
Uncontrolled Keywords: Endocrinology, Diabetes and Metabolism,Endocrinology
Publication ISSN: 1759-5037
Last Modified: 21 Oct 2024 16:42
Date Deposited: 15 Oct 2024 12:13
Full Text Link: https://www.rep ... c2-f60640c3fe7e
Related URLs: http://www.scop ... tnerID=8YFLogxK (Scopus URL)
https://www.nat ... 574-024-01024-5 (Publisher URL)
PURE Output Type: Article
Published Date: 2024-08-15
Published Online Date: 2024-08-15
Accepted Date: 2024-07-17
Authors: Casey, Ruth T.
Hendriks, Emile
Deal, Cheri
Waguespack, Steven G.
Wiegering, Verena
Redlich, Antje
Akker, Scott
Prasad, Rathi
Fassnacht, Martin
Clifton-Bligh, Roderick
Amar, Laurence
Bornstein, Stefan
Canu, Letizia
Charmandari, Evangelia
Chrisoulidou, Alexandra
Freixes, Maria Currás
de Krijger, Ronald
de Sanctis, Luisa
Fojo, Antonio
Ghia, Amol J.
Huebner, Angela
Kosmoliaptsis, Vasilis
Kuehlen, Michaela
Raffaelli, Marco
Lussey-Lepoutre, Charlotte
Marks, Stephen D.
Nilubol, Naris
Parasiliti-Caprino, Mirko
Timmers, Henri H.J.L.M.
Zietlow, Anna Lena
Robledo, Mercedes
Gimenez-Roqueplo, Anne Paule
Grossman, Ashley B.
Taïeb, David
Maher, Eamonn R.
Lenders, Jacques W.M.
Eisenhofer, Graeme
Jimenez, Camilo
Pacak, Karel
Pamporaki, Christina

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