Ball, James D., Hills, Eleanor, Altaf, Afzaa, Ramesh, Pranav, Green, Matthew, Surti, Farhaana B.S., Minhas, Jatinder S., Robinson, Thompson G., Bond, Bert, Lester, Alice, Hoiland, Ryan, Klein, Timo, Liu, Jia, Nasr, Nathalie, Junejo, Rehan T., Müller, Martin, Lecchini-Visintini, Andrea, Mitsis, Georgios, Burma, Joel S., Smirl, Jonathan D., Pizzi, Michael A., Manquat, Elsa, Lucas, Samuel J. E., Mullinger, Karen J., Mayhew, Steve, Bailey, Damian M., Rodrigues, Gabriel, Soares, Pedro Paulo, Phillips, Aaron A., Prokopiou, Prokopis C. and Beishon, Lucy C. (2024). Neurovascular coupling methods in healthy individuals using transcranial doppler ultrasonography: A systematic review and consensus agreement. Journal of Cerebral Blood Flow and Metabolism ,
Abstract
Neurovascular coupling (NVC) is the perturbation of cerebral blood flow (CBF) to meet varying metabolic demands induced by various levels of neural activity. NVC may be assessed by Transcranial Doppler ultrasonography (TCD), using task activation protocols, but with significant methodological heterogeneity between studies, hindering cross-study comparisons. Therefore, this review aimed to summarise and compare available methods for TCD-based healthy NVC assessments. Medline (Ovid), Scopus, Web of Science, EMBASE (Ovid) and CINAHL were searched using a predefined search strategy (PROSPERO: CRD42019153228), generating 6006 articles. Included studies contained TCD-based assessments of NVC in healthy adults. Study quality was assessed using a checklist, and findings were synthesised narratively. 76 studies (2697 participants) met the review criteria. There was significant heterogeneity in the participant position used (e.g., seated vs supine), in TCD equipment, and vessel insonated (e.g. middle, posterior, and anterior cerebral arteries). Larger, more significant, TCD-based NVC responses typically included a seated position, baseline durations >one-minute, extraneous light control, and implementation of previously validated protocols. In addition, complementary, combined position, vessel insonated and stimulation type protocols were associated with more significant NVC results. Recommendations are detailed here, but further investigation is required in patient populations, for further optimisation of TCD-based NVC assessments.
Publication DOI: | https://doi.org/10.1177/0271678x241270452 |
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Divisions: | College of Health & Life Sciences > School of Psychology College of Health & Life Sciences Aston University (General) |
Funding Information: | The author(s) disclosed receipt of the following financial sup- port for the research, authorship, and/or publication of this article: JB is an NIHR ARC-funded PhD student. JSM holds a Stroke Association Senior Clinical Lectureship (SA SCLM23\100003). LB |
Additional Information: | Copyright © 2024 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/). |
Uncontrolled Keywords: | healthy,narrative summary,neurovascular coupling,systematic review,transcranial doppler ultrasonography |
Publication ISSN: | 1559-7016 |
Data Access Statement: | This was a systematic review of existing research studies and no primary research was conducted |
Last Modified: | 27 Nov 2024 08:20 |
Date Deposited: | 19 Aug 2024 13:16 |
Full Text Link: | |
Related URLs: |
https://journal ... 71678X241270452
(Publisher URL) http://www.scop ... tnerID=8YFLogxK (Scopus URL) |
PURE Output Type: | Review article |
Published Date: | 2024-08-07 |
Published Online Date: | 2024-08-07 |
Accepted Date: | 2024-05-09 |
Authors: |
Ball, James D.
Hills, Eleanor Altaf, Afzaa Ramesh, Pranav Green, Matthew Surti, Farhaana B.S. Minhas, Jatinder S. Robinson, Thompson G. Bond, Bert Lester, Alice Hoiland, Ryan Klein, Timo Liu, Jia Nasr, Nathalie Junejo, Rehan T. Müller, Martin Lecchini-Visintini, Andrea Mitsis, Georgios Burma, Joel S. Smirl, Jonathan D. Pizzi, Michael A. Manquat, Elsa Lucas, Samuel J. E. Mullinger, Karen J. Mayhew, Steve ( 0000-0003-1240-1488) Bailey, Damian M. Rodrigues, Gabriel Soares, Pedro Paulo Phillips, Aaron A. Prokopiou, Prokopis C. Beishon, Lucy C. |