Wan, Eric Y. F., Wong, Zoey C. T., Yan, Vincent K. C., Chui, Celine S. L., Lai, Francisco T. T., Li, Xue, Wong, Ian C. K. and Chan, Esther W. Y. (2024). Comparing the effectiveness of molnupiravir and nirmatrelvir‐ritonavir in non‐hospitalized and hospitalized COVID ‐19 patients with type 2 diabetes:A target trial emulation study. Diabetes, Obesity and Metabolism, 26 (10), pp. 4653-4664.
Abstract
Aims: To compare the effectiveness of molnupiravir and nirmatrelvir‐ritonavir for non‐hospitalized and hospitalized COVID‐19 patients with type 2 diabetes (T2DM). Materials and Methods: Territory‐wide electronic health records in Hong Kong were used to perform target trial emulation using a sequential trial approach. Patients (1) aged ≥18 years, (2) with T2DM, (3) with COVID‐19 infection, and (4) who received molnupiravir or nirmatrelvir‐ritonavir within 5 days of infection between 16 March 2022 and 31 December 2022 in non‐hospital and hospital settings were included. Molnupiravir and nirmatrelvir‐ritonavir initiators were matched using one‐to‐one propensity‐score matching and followed for 28 days. Risk of outcomes was compared between groups by Cox regression adjusted for baseline characteristics. Subgroup analyses were performed on age (
| Publication DOI: | https://doi.org/10.1111/dom.15830 |
|---|---|
| Divisions: | College of Health & Life Sciences > Aston Pharmacy School College of Health & Life Sciences |
| Funding Information: | This work was supported by HMRF Research on COVID\u201019, the HKSAR Government (Principal Investigator [WP2]: Esther W. Y. Chan; ref no. COVID1903011), the Collaborative Research Fund, University Grants Committee, the HKSAR Government (Principal Investigator: Ian C. K. Wong; ref. no. C7154\u201020GF), and a research grant from the Food and Health Bureau, the HKSAR Government (Principal Investigator: Ian C. K. Wong; ref. no. COVID19F01). Ian C. K. Wong and Francisco T. T. Lai are partially supported by the Laboratory of Data Discovery for Health (D4H) funded by the by AIR@InnoHK administered by Innovation and Technology Commission. We gratefully acknowledge the Centre for Health Protection, the Department of Health and the Hospital Authority for facilitating data access. |
| Additional Information: | Published CC BY NC Publisher Copyright: © 2024 The Author(s). Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd. |
| Uncontrolled Keywords: | effectiveness,pharmacoepidemiology,real-world evidence,type 2 diabetes,Endocrinology,Internal Medicine,Endocrinology, Diabetes and Metabolism |
| Publication ISSN: | 1463-1326 |
| Data Access Statement: | Data are not available as the data custodians (the Hospital Authority and the Department of Health of Hong Kong SAR) have not given permission for sharing due to patient confidentiality and privacy concerns. Local academic institutions, government departments, or non-governmental organizations may apply for the access to data through the Hospital Authority's data sharing portal (https://www3.ha.org.hk/data). |
| Last Modified: | 25 Feb 2026 08:10 |
| Date Deposited: | 16 Aug 2024 13:52 |
| Full Text Link: | |
| Related URLs: |
https://dom-pub ... .1111/dom.15830
(Publisher URL) https://www.sco ... ons/85200549223 (Scopus URL) |
PURE Output Type: | Article |
| Published Date: | 2024-10 |
| Published Online Date: | 2024-08-07 |
| Accepted Date: | 2024-07-03 |
| Submitted Date: | 2024-05-11 |
| Authors: |
Wan, Eric Y. F.
Wong, Zoey C. T. Yan, Vincent K. C. Chui, Celine S. L. Lai, Francisco T. T. Li, Xue Wong, Ian C. K. ( 
0000-0001-8242-0014)
Chan, Esther W. Y. |