A systematic review of optical coherence tomography findings in adults with mild traumatic brain injury

Abstract

Mild traumatic brain injury (mTBI) is common with many patients suffering disabling long-term sequelae, with visual symptoms frequently reported. There are no objective biomarkers of mTBI that are routinely used in clinical practice. Optical coherence tomography (OCT) has been used in mTBI research, as it enables visualisation of the neuroretina, allowing measurement of the retinal nerve fibre layer and ganglion cell layer. This systematic review aims to appraise the available literature and assess whether there are significant changes within the retinal nerve fibre layer and ganglion cell layer in subjects after mTBI. A systematic review was carried out in accordance with PRISMA guidelines and registered with PROSPERO (Number: CRD42022360498). Four databases were searched for relevant literature published from inception until 1 September 2022. Abstracts and full texts were screened by three independent reviewers. Initial screening of databases yielded 341 publications, of these, three fulfilled all the criteria for inclusion. All three studies showed thinning of the retinal nerve fibre layer, whereas there were no significant changes in the ganglion cell layer. This systematic review demonstrated that thinning of the retinal nerve fibre layer (but not of the ganglion cell layer) is associated with mTBI. It provides preliminary evidence for the use of the retinal nerve fibre layer as a potential biomarker of damage to the visual system in mTBI. Further prospective longitudinal studies ensuring uniform diagnosis and accurate phenotyping of mTBI are needed to understand the effects on the visual system and potential of OCT as a prognostic biomarker.

Publication DOI: https://doi.org/10.1038/s41433-023-02845-w
Divisions: College of Health & Life Sciences > School of Psychology
Aston University (General)
Funding Information: This work was funded by the Ministry of Defence, UK, through the mTBI Predict Consortium.
Additional Information: Copyright © Crown 2024. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/
Publication ISSN: 1476-5454
Last Modified: 21 Nov 2024 08:21
Date Deposited: 15 Aug 2024 16:54
Full Text Link:
Related URLs: https://www.nat ... 433-023-02845-w (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Review article
Published Date: 2024-04
Published Online Date: 2024-01-18
Accepted Date: 2023-11-13
Authors: Lyons, Hannah S.
Sassani, Matilde
Hyder, Yousef
Mitchell, James L.
Thaller, Mark
Mollan, Susan
Sinclair, Alexandra J.
Blanch, Richard J.
Sinclair, Alexandra
Finch, Aliza
Hampshire, Adam
Sitch, Alice
Mazaheri, Ali
Bagshaw, Andrew
Palmer, Andy
Strom, Asha
Waitt, Alice
Yiangou, Andreas
Abdel-Hay, Ahmed
Bennett, Alexander
Clark, Amy
Hunter, Angus
Seemungal, Barry
Witton, Caroline (ORCID Profile 0000-0002-5610-4234)
Dooley, Caroline
Bird, Deborah
Fernandez-Espejo, Davinia
Smith, Dave
Ford, Dan
Sherwood, Daniel
Holding, Donna
Wilson, Duncan
Palmer, Edward
Golding, John
Dehghani, Hamid
Park, Hyojin
Lyons, Hannah
Smith, Hazel
Brunger, Helen
Ellis, Henrietta
Idrees, Iman
Varley, Ian
Hubbard, Jessica
Cao, Jun
Deeks, Jon
Mitchell, James
Novak, Jan (ORCID Profile 0000-0001-5173-3608)
Pringle, Jamie
Terry, John
Rogers, Jack
Read, Tim
Fildes, Jessikah
Mullinger, Karen
Hill, Lisa
Aurisicchio, Marco
Thaller, Mark
Wilson, Martin
Pearce, Mark
Sassani, Matilde
Brookes, Matthew
Mahmud, Mohammad
Rayhan, Ray
Jenkinson, Ned
Karavitaki, Niki
Capewell, Nick
Grech, Olivia
Jensen, Ole
Hellyer, Pete
Woodgate, Philip
Coleman, Sebastian
Reynolds, Raymond
Blanch, Richard J.
Morris, Katie
Ottridge, Ryan
Upthegrove, Rachel
Dardis, Ronan
Arachchige, Ruwan Wanni
Berhane, Sarah
Lucas, Sam
Prosser, Sophie
Sharifi, Shayan
Dharm-Datta, Shreshth
Mollan, Susan
Ellmers, Toby
Ghafari, Tara
Goldstone, Tony
Hawa, Waheeda
Gao, Yidian

Download

[img]

Version: Published Version

License: Creative Commons Attribution

| Preview

Export / Share Citation


Statistics

Additional statistics for this record