Lyons, Hannah S., Sassani, Matilde, Hyder, Yousef, Mitchell, James L., Thaller, Mark, Mollan, Susan, Sinclair, Alexandra J., Blanch, Richard J., Sinclair, Alexandra, Finch, Aliza, Hampshire, Adam, Sitch, Alice, Mazaheri, Ali, Bagshaw, Andrew, Palmer, Andy, Strom, Asha, Waitt, Alice, Yiangou, Andreas, Abdel-Hay, Ahmed, Bennett, Alexander, Clark, Amy, Hunter, Angus, Seemungal, Barry, Witton, Caroline, Dooley, Caroline, Bird, Deborah, Fernandez-Espejo, Davinia, Smith, Dave, Ford, Dan, Sherwood, Daniel, Holding, Donna, Wilson, Duncan, Palmer, Edward, Golding, John, Dehghani, Hamid, Park, Hyojin, Lyons, Hannah, Smith, Hazel, Brunger, Helen, Ellis, Henrietta, Idrees, Iman, Varley, Ian, Hubbard, Jessica, Cao, Jun, Deeks, Jon, Mitchell, James, Novak, Jan, Pringle, Jamie, Terry, John, Rogers, Jack, Read, Tim, Fildes, Jessikah, Mullinger, Karen, Hill, Lisa, Aurisicchio, Marco, Thaller, Mark, Wilson, Martin, Pearce, Mark, Sassani, Matilde, Brookes, Matthew, Mahmud, Mohammad, Rayhan, Ray, Jenkinson, Ned, Karavitaki, Niki, Capewell, Nick, Grech, Olivia, Jensen, Ole, Hellyer, Pete, Woodgate, Philip, Coleman, Sebastian, Reynolds, Raymond, Blanch, Richard J., Morris, Katie, Ottridge, Ryan, Upthegrove, Rachel, Dardis, Ronan, Arachchige, Ruwan Wanni, Berhane, Sarah, Lucas, Sam, Prosser, Sophie, Sharifi, Shayan, Dharm-Datta, Shreshth, Mollan, Susan, Ellmers, Toby, Ghafari, Tara, Goldstone, Tony, Hawa, Waheeda and Gao, Yidian (2024). A systematic review of optical coherence tomography findings in adults with mild traumatic brain injury. Eye (Basingstoke), 38 (6), pp. 1077-1083.
Abstract
Mild traumatic brain injury (mTBI) is common with many patients suffering disabling long-term sequelae, with visual symptoms frequently reported. There are no objective biomarkers of mTBI that are routinely used in clinical practice. Optical coherence tomography (OCT) has been used in mTBI research, as it enables visualisation of the neuroretina, allowing measurement of the retinal nerve fibre layer and ganglion cell layer. This systematic review aims to appraise the available literature and assess whether there are significant changes within the retinal nerve fibre layer and ganglion cell layer in subjects after mTBI. A systematic review was carried out in accordance with PRISMA guidelines and registered with PROSPERO (Number: CRD42022360498). Four databases were searched for relevant literature published from inception until 1 September 2022. Abstracts and full texts were screened by three independent reviewers. Initial screening of databases yielded 341 publications, of these, three fulfilled all the criteria for inclusion. All three studies showed thinning of the retinal nerve fibre layer, whereas there were no significant changes in the ganglion cell layer. This systematic review demonstrated that thinning of the retinal nerve fibre layer (but not of the ganglion cell layer) is associated with mTBI. It provides preliminary evidence for the use of the retinal nerve fibre layer as a potential biomarker of damage to the visual system in mTBI. Further prospective longitudinal studies ensuring uniform diagnosis and accurate phenotyping of mTBI are needed to understand the effects on the visual system and potential of OCT as a prognostic biomarker.
Publication DOI: | https://doi.org/10.1038/s41433-023-02845-w |
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Divisions: | College of Health & Life Sciences > School of Psychology Aston University (General) |
Funding Information: | This work was funded by the Ministry of Defence, UK, through the mTBI Predict Consortium. |
Additional Information: | Copyright © Crown 2024. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/ |
Publication ISSN: | 1476-5454 |
Last Modified: | 21 Nov 2024 08:21 |
Date Deposited: | 15 Aug 2024 16:54 |
Full Text Link: | |
Related URLs: |
https://www.nat ... 433-023-02845-w
(Publisher URL) http://www.scop ... tnerID=8YFLogxK (Scopus URL) |
PURE Output Type: | Review article |
Published Date: | 2024-04 |
Published Online Date: | 2024-01-18 |
Accepted Date: | 2023-11-13 |
Authors: |
Lyons, Hannah S.
Sassani, Matilde Hyder, Yousef Mitchell, James L. Thaller, Mark Mollan, Susan Sinclair, Alexandra J. Blanch, Richard J. Sinclair, Alexandra Finch, Aliza Hampshire, Adam Sitch, Alice Mazaheri, Ali Bagshaw, Andrew Palmer, Andy Strom, Asha Waitt, Alice Yiangou, Andreas Abdel-Hay, Ahmed Bennett, Alexander Clark, Amy Hunter, Angus Seemungal, Barry Witton, Caroline ( 0000-0002-5610-4234) Dooley, Caroline Bird, Deborah Fernandez-Espejo, Davinia Smith, Dave Ford, Dan Sherwood, Daniel Holding, Donna Wilson, Duncan Palmer, Edward Golding, John Dehghani, Hamid Park, Hyojin Lyons, Hannah Smith, Hazel Brunger, Helen Ellis, Henrietta Idrees, Iman Varley, Ian Hubbard, Jessica Cao, Jun Deeks, Jon Mitchell, James Novak, Jan ( 0000-0001-5173-3608) Pringle, Jamie Terry, John Rogers, Jack Read, Tim Fildes, Jessikah Mullinger, Karen Hill, Lisa Aurisicchio, Marco Thaller, Mark Wilson, Martin Pearce, Mark Sassani, Matilde Brookes, Matthew Mahmud, Mohammad Rayhan, Ray Jenkinson, Ned Karavitaki, Niki Capewell, Nick Grech, Olivia Jensen, Ole Hellyer, Pete Woodgate, Philip Coleman, Sebastian Reynolds, Raymond Blanch, Richard J. Morris, Katie Ottridge, Ryan Upthegrove, Rachel Dardis, Ronan Arachchige, Ruwan Wanni Berhane, Sarah Lucas, Sam Prosser, Sophie Sharifi, Shayan Dharm-Datta, Shreshth Mollan, Susan Ellmers, Toby Ghafari, Tara Goldstone, Tony Hawa, Waheeda Gao, Yidian |