Language and communication functioning in children and adolescents with agenesis of the corpus callosum

Abstract

The corpus callosum, the largest white matter inter-hemispheric pathway, is involved in language and communication. In a cohort of 15 children and adolescents (8-15 years) with developmental absence of the corpus callosum (AgCC), this study aimed to describe language and everyday communication functioning, and explored the role of anatomical factors, social risk, and non-verbal IQ in these outcomes. Standardised measures of language and everyday communication functioning, intellectual ability and social risk were used. AgCC classification and anterior commissure volume, a potential alternative pathway, were extracted from T1-weighted images. Participants with AgCC showed reduced receptive and expressive language compared with test norms, and high rates of language and communication impairments. Complete AgCC, higher social risk and lower non-verbal IQ were associated with communication difficulties. Anterior commissure volume was not associated with language and communication. Recognising heterogeneity in language and communication functioning enhances our understanding and suggests specific focuses for potential interventions. [Abstract copyright: Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.]

Publication DOI: https://doi.org/10.1016/j.bandl.2024.105448
Divisions: College of Health & Life Sciences > School of Psychology
College of Health & Life Sciences > Aston Institute of Health & Neurodevelopment (AIHN)
College of Health & Life Sciences
Funding Information: This study was supported by the Boninchi Foundation from the University of Geneva; the Victorian Government's Operational Infrastructure Support Program; and the Murdoch Children's Research Institute. Professor Richard J. Leventer was supported by a Melbo
Additional Information: Copyright © 2024 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/).
Uncontrolled Keywords: Agenesis of Corpus Callosum,Corpus callosum,Language and communication,Children and adolescents,Developmental neuropsychology
Publication ISSN: 1090-2155
Last Modified: 04 Oct 2024 07:38
Date Deposited: 14 Aug 2024 15:45
Full Text Link:
Related URLs: https://www.sci ... 093934X24000713 (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2024-08
Published Online Date: 2024-07-30
Accepted Date: 2024-07-22
Authors: Moser, Charlene
Spencer-Smith, Megan M.
Anderson, Peter J.
McIlroy, Alissandra
Wood, Amanda G. (ORCID Profile 0000-0002-1537-6858)
Leventer, Richard J.
Anderson, Vicki A.
Siffredi, Vanessa

Download

[img]

Version: Published Version

License: Creative Commons Attribution

| Preview

Export / Share Citation


Statistics

Additional statistics for this record