Yu, Qiuyan, Fan, Min, Lin, Celia Jiaxi, Lui, David Tak Wai, Tan, Kathryn Choon Beng, Yiu, Kai Hang, Akyea, Ralph Kwame, Qureshi, Nadeem, Lai, Francisco Tsz Tsun, Wan, Eric Yuk Fai, Li, Xue, Chan, Esther Wai Yin, Wong, Ian Chi Kei and Chui, Celine Sze Ling (2024). Risk factors for long-term cardiovascular post-acute sequelae of COVID-19 infection: A nested case-control study in Hong Kong. npj Cardiovascular Health, 1 (1),
Abstract
People with COVID-19 can experience post-acute sequelae of SARS-CoV-2 (PASC). Studies on risk factors of PASC outcomes are ongoing, especially for endocrine system-related diseases that may impact the cardiovascular system. Cardiac-related PASC is one of the burdens after COVID-19 infection. This study aimed to examine the risk factors of cardiac-related PASC. In this nested case-control study, we obtained electronic health records (EHRs) database from the Hong Kong Hospital Authority. We defined cases as patients with at least one cardiac-related PASC and controls as patients without any cardiac-related PASC. We applied the incidence density sampling and matched controls to cases on age and sex at a 1:10 ratio. Multivariable conditional logistic regression was used to determine the associations between risk factors and cardiac-related PASC. A total of 455 individuals with cardiac-related PASC and matched 3,423 controls were obtained in the underlying cohort. COVID-19-associated hospitalisation (aOR: 1.41, 95% CI: 1.03–1.93) and peripheral vascular disease (aOR: 2.98, 95% CI: 1.31–6.79) were associated with an increased likelihood of cardiac-related PASC. Higher doses of the COVID-19 vaccine (2 doses: 0.68 [0.52–0.89]; ≥3 doses: 0.56 [0.40–0.78]) and more frequent healthcare utilization visits (aOR: 0.95, 95% CI: 0.92–0.97) were associated with a lower likelihood of cardiac-related PASC. This is the first study to examine risk factors of cardiac-related PASC among the Chinese population. We identified peripheral vascular disease and COVID-19-associated hospitalisation as the risk factors for cardiac-related PASC. COVID-19 vaccination was protective against cardiac-related PASC, which should be prioritized for high-risk patients.
Publication DOI: | https://doi.org/10.1038/s44325-024-00011-z |
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Divisions: | College of Health & Life Sciences > Aston Pharmacy School |
Funding Information: | This work was supported by funding from the Collaborative Research Fund, University Grants Committee, the HKSAR Government (principal investigator, ICKW; ref. no. C7154-20GF); and a research grant from the Health Bureau, the HKSAR Government (principal in |
Additional Information: | Copyright © The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/ |
Publication ISSN: | 2948-2836 |
Last Modified: | 06 Aug 2024 10:03 |
Date Deposited: | 05 Aug 2024 11:34 |
Full Text Link: | |
Related URLs: |
https://www.nat ... 325-024-00011-z
(Publisher URL) |
PURE Output Type: | Article |
Published Date: | 2024-12 |
Published Online Date: | 2024-08-02 |
Accepted Date: | 2024-06-26 |
Authors: |
Yu, Qiuyan
Fan, Min Lin, Celia Jiaxi Lui, David Tak Wai Tan, Kathryn Choon Beng Yiu, Kai Hang Akyea, Ralph Kwame Qureshi, Nadeem Lai, Francisco Tsz Tsun Wan, Eric Yuk Fai Li, Xue Chan, Esther Wai Yin Wong, Ian Chi Kei ( ![]() Chui, Celine Sze Ling |