Kang, Wei, Huang, Caige, Yan, Vincent K. C., Wei, Yue, Shami, Jessica J. P., Li, Silvia T. H., Yang, Yu, Ye, Xuxiao, Tang, Junhan, Lee, Shing Fung, Lee, Victor H. F., Chan, Stephen L., El Helali, Aya, Lam, Ka On, Ngan, Roger K. C., Wong, Ian C. K. and Chan, Esther W. (2024). Effectiveness and safety of continuous low-molecular-weight heparin versus switching to direct oral anticoagulants in cancer-associated venous thrombosis. Nature Communications, 15 (1),
Abstract
Given the existing uncertainty regarding the effectiveness and safety of switching from low-molecular-weight heparin (LMWH) to direct oral anticoagulants (DOACs) in patients with cancer-associated venous thrombosis (CAT), we conducted a comprehensive population-based cohort study utilizing electronic health database in Hong Kong. A total of 4356 patients with CAT between 2010 and 2022 were included, with 1700 (39.0%) patients switching to DOAC treatment. Compared to continuous LMWH treatment, switching to DOACs was associated with a significantly lower risk of hospitalization due to venous thromboembolism (HR: 0.49 [95% CI = 0.35–0.68]) and all-cause mortality (HR: 0.67 [95% CI = 0.61–0.74]), with no significant difference in major bleeding (HR: 1.04 [95% CI = 0.83–1.31]) within six months. These findings provide reassurance regarding the effectiveness and safety of switching from LMWH to DOACs among patients with CAT, including vulnerable patient groups.
| Publication DOI: | https://doi.org/10.1038/s41467-024-50037-1 |
|---|---|
| Divisions: | College of Health & Life Sciences > Aston Pharmacy School |
| Funding Information: | This study was supported by the Hong Kong Research Grants Council, General Research Fund (GRF), No. 17108621, which was received by E.W.C. The funding source had no role in the design and conduct of the study, collection, management, analysis, and interpr |
| Additional Information: | Copyright © The Author(s) 2024. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/ |
| Publication ISSN: | 2041-1723 |
| Last Modified: | 16 Aug 2024 07:17 |
| Date Deposited: | 02 Aug 2024 16:44 |
| Full Text Link: | |
| Related URLs: |
http://www.scop ... tnerID=8YFLogxK
(Scopus URL) https://www.nat ... 467-024-50037-1 (Publisher URL) |
PURE Output Type: | Article |
| Published Date: | 2024-12 |
| Published Online Date: | 2024-07-05 |
| Accepted Date: | 2024-06-25 |
| Submitted Date: | 2023-07-24 |
| Authors: |
Kang, Wei
Huang, Caige Yan, Vincent K. C. Wei, Yue Shami, Jessica J. P. Li, Silvia T. H. Yang, Yu Ye, Xuxiao Tang, Junhan Lee, Shing Fung Lee, Victor H. F. Chan, Stephen L. El Helali, Aya Lam, Ka On Ngan, Roger K. C. Wong, Ian C. K. ( 
0000-0001-8242-0014)
Chan, Esther W. |
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)