Srimai, Chadaporn, Sukmongkolwongs, Waewploy, Manokruang, Kiattikhun, Worajittiphon, Patnarin, Molloy, Robert, Mahomed, Anisa and Somsunan, Runglawan (2024). Enhancement of Poly(vinyl alcohol) Hydrogel Properties by N-Succinyl Chitosan and Mesona chinensis Extract for Use as Wound Dressings. European Polymer Journal, 215 ,
Abstract
Hydrogels composed of different ratios of poly(vinyl alcohol), N-succinyl chitosan (NSC), and Mesona chinensis extract, for use as a wound dressing, were synthesized via thermal polymerization. Potassium persulfate was chosen as the initiator and glutaraldehyde as the crosslinking agent. NSC was prepared by modification of chitosan with succinic anhydride. It was found that this preparation method gave a high gel fraction percentage. The structures of the prepared hydrogels were characterized by Fourier-transform infrared spectroscopy, and their morphology by scanning electron microscopy (SEM). In addition, water transport properties, mechanical properties and cytotoxicity were also studied. The SEM results show that the hydrogels exhibited porous structures and that pore size and size distribution increased with increasing NSC content. Hydrogel-water interactions and water transport properties were also studied in terms of swelling ratio, equilibrium water retention, and water vapour transmission rate. These showed an increase, from 637 to 1240 %, 17.8 to 21.4 %, and 110 to 121 g h−1 m−2 respectively with an increase in NSC content. These gels exhibit a lower water vapour transmission rate compared to that of second and third degree burns but higher than normal skin. Similarly, NSC improved the mechanical properties, presented in terms of stress and percentage strain, of the hydrogels. The stress, percentage strain, and Young’s modulus were found to increase from 15 to 32 kPa, 197 to 294 %, and 0.078 to 0.133 kPa respectively. The hydrogels can be considered to be non-toxic based on the in vitro cytotoxicity assay results. In conclusion, the results showed that, by varying composition, hydrogel properties can be tuned to the specific requirements of an ideal wound dressing.
Publication DOI: | https://doi.org/10.1016/j.eurpolymj.2024.113212 |
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Divisions: | College of Engineering & Physical Sciences > School of Infrastructure and Sustainable Engineering > Chemical Engineering & Applied Chemistry College of Engineering & Physical Sciences > Aston Advanced Materials College of Engineering & Physical Sciences > Engineering for Health College of Engineering & Physical Sciences > Aston Polymer Research Group College of Engineering & Physical Sciences Aston University (General) |
Funding Information: | This research work was partially supported by Chiang Mai University. It also has received partial funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 871650 (MEDIPOL). The au |
Additional Information: | Copyright © 2024 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ |
Uncontrolled Keywords: | Hydrogel,Mesona chinensis extract,N-succinyl chitosan,Poly(vinyl alcohol),Wound dressing,Materials Chemistry,Polymers and Plastics,General Physics and Astronomy,Organic Chemistry |
Publication ISSN: | 1873-1945 |
Last Modified: | 03 Dec 2024 08:22 |
Date Deposited: | 29 Jul 2024 17:22 |
Full Text Link: | |
Related URLs: |
http://www.scop ... tnerID=8YFLogxK
(Scopus URL) https://www.sci ... 014305724004737 (Publisher URL) |
PURE Output Type: | Article |
Published Date: | 2024-07-17 |
Published Online Date: | 2024-06-11 |
Accepted Date: | 2024-06-08 |
Authors: |
Srimai, Chadaporn
Sukmongkolwongs, Waewploy Manokruang, Kiattikhun Worajittiphon, Patnarin Molloy, Robert Mahomed, Anisa ( 0000-0002-3719-7543) Somsunan, Runglawan |
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