Yiu, Hei Hang Edmund, Yan, Vincent K. C., Wei, Yue, Ye, Xuxiao, Huang, Caige, Castle, David J., Chui, Celine S. L., Lai, Francisco T. T., Li, Xue, Wong, Carlos K. H., Wan, Eric Y. F., Wong, Ian C. K. and Chan, Esther W. (2023). Risks of COVID-19-related hospitalisation and mortality among individuals with mental disorders following BNT162b2 and CoronaVac vaccinations: A case-control study. Psychiatry Research, 329 ,
Abstract
Concerns have been raised regarding potential weaker vaccine immunogenicity with higher immune suppression for individuals with pre-existing mental disorders. Yet, data on the effectiveness of COVID-19 vaccinations among this vulnerable population are limited. A case-control study was conducted to investigate the risks of COVID-19-related hospitalisation and mortality among individuals with mental disorders following one to three doses of BNT162b2 and CoronaVac vaccinations in Hong Kong. Data were extracted from electronic health records, vaccination and COVID-19 confirmed case records. Conditional logistic regression was applied with adjustment for comorbidities and medication history. Subgroup analyses were performed with stratification: by age (< 65 and ≥ 65) and mental disorders diagnosis (depression, schizophrenia, anxiety disorder, and bipolar disorder). Two doses of BNT162b2 and CoronaVac significantly reduced COVID-19-related hospitalisation and mortality. Further protection for both outcomes was provided after three doses of BNT162b2 and CoronaVac. The vaccine effectiveness magnitude of BNT162b2 was generally higher than CoronaVac, but the difference diminished after the third dose. Individuals with mental disorders should be prioritised in future mass vaccination programmes of booster doses or bivalent COVID-19 vaccines. Targeted strategies should be developed to resolve the reasons behind vaccine hesitancy among this population and increase their awareness on the benefits of vaccination.
Publication DOI: | https://doi.org/10.1016/j.psychres.2023.115515 |
---|---|
Divisions: | College of Health & Life Sciences > Aston Pharmacy School |
Funding Information: | This work was supported by a research grant from the Health Bureau; HMRF Research on COVID-19, The Government of the Hong Kong Special Administrative Region (principal investigator [work package 2], EWC; reference no. COVID1903011). The authors gratefully |
Additional Information: | Copyright © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/). |
Uncontrolled Keywords: | Humans,COVID-19 Vaccines,BNT162 Vaccine,COVID-19/prevention & control,Case-Control Studies,Mental Disorders,Vaccination,Hospitalization |
Publication ISSN: | 0165-1781 |
Last Modified: | 06 Aug 2024 10:02 |
Date Deposited: | 19 Jul 2024 16:32 |
Full Text Link: | |
Related URLs: |
https://www.sci ... 165178123004651
(Publisher URL) |
PURE Output Type: | Article |
Published Date: | 2023-11 |
Published Online Date: | 2023-10-04 |
Accepted Date: | 2023-09-29 |
Authors: |
Yiu, Hei Hang Edmund
Yan, Vincent K. C. Wei, Yue Ye, Xuxiao Huang, Caige Castle, David J. Chui, Celine S. L. Lai, Francisco T. T. Li, Xue Wong, Carlos K. H. Wan, Eric Y. F. Wong, Ian C. K. ( ![]() Chan, Esther W. |