Vaghef-Mehrabani, Elnaz, Bell, Rhonda C., Field, Catherine J., Jarman, Megan, Evanchuk, Jenna L., Letourneau, Nicole and Giesbrecht, Gerald F. (2024). Maternal pre-pregnancy diet and prenatal depression: The mediating role of pre-pregnancy weight status and prenatal inflammation. British Journal of Nutrition , pp. 1-15.
Abstract
Depression is a common prenatal psychological complication. We aimed to investigate if maternal pre-pregnancy diet can impact prenatal depressive symptoms, and the mediating role of pre-pregnancy body mass index (BMI) and inflammation. We used data (N=1141) from the Alberta Pregnancy Outcomes and Nutrition (APrON) cohort study. We calculated Mediterranean diet adherence (MED) and dietary inflammatory index (DII) scores using data from pre-pregnancy food frequency questionnaire (FFQ). In the 3rd-Trimester, we assessed depressive symptoms using Edinburgh Postpartum Depression Scale (EPDS), and inflammation through serum C-reactive protein (CRP) levels. BMI was calculated from self-reported pre-pregnancy weight. Race-stratified analyses (white and people of color) were run. We observed no association between MED or DII tertiles and depressive symptoms. However, white participants in the MED tertile-3 had lower risk of depression (EPDS<10) compared to tertile-1 (OR=0.56, 95% CI, 0.33, 0.95). White individuals in MED tertile-3 had lower BMI (MD=-1.08; 95%CI,-1.77,-0.39), and CRP (MD=-0.53; 95%CI,-0.95,-0.11) than tertile-1, and those in DII tertile-2 (MD=0.44;95%CI, 0.03, 0.84) and tertile-3 (MD=0.42; 95%CI, 0.01, 0.83) had higher CRP than tertile-1. Among people of color, neither MED nor DII were associated with BMI or CRP, but BMI was negatively associated with depressive symptoms (β=-0.25, 95%CI,-0.43,-0.06). We found no association between diet and depressive symptoms through BMI or CRP, in either race. Pre-pregnancy diet might affect the risk of prenatal depression in a race-specific way. Further research is required to explore the racial differences in the association between maternal diet and prenatal depressive symptoms/depression risk.
Publication DOI: | https://doi.org/10.1017/S0007114524001028 |
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Divisions: | College of Health & Life Sciences > School of Psychology College of Health & Life Sciences > Aston Institute of Health & Neurodevelopment (AIHN) |
Additional Information: | Copyright © The Authors 2024. Published by Cambridge University Press on behalf of The Nutrition Society. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited. |
Uncontrolled Keywords: | C-reactive protein (CRP),Body mass index (BMI),Dietary inflammatory index (DII),Mediterranean diet,Prenatal depression |
Publication ISSN: | 1475-2662 |
Last Modified: | 16 Aug 2024 07:17 |
Date Deposited: | 17 Jun 2024 16:01 |
Full Text Link: | |
Related URLs: |
https://www.cam ... 8D5C9773DCD59BE
(Publisher URL) http://www.scop ... tnerID=8YFLogxK (Scopus URL) |
PURE Output Type: | Article |
Published Date: | 2024-05-27 |
Published Online Date: | 2024-05-27 |
Accepted Date: | 2024-05-02 |
Authors: |
Vaghef-Mehrabani, Elnaz
Bell, Rhonda C. Field, Catherine J. Jarman, Megan ( ![]() Evanchuk, Jenna L. Letourneau, Nicole Giesbrecht, Gerald F. |
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