Erdinest, Nir, London, Naomi, Landau, David, Barbara, Ramez, Barbara, Adel and Naroo, Shehzad A (2024). Higher order aberrations in keratoconus. International Ophthalmology, 44 (1),
Abstract
Introduction: Keratoconus is a progressive disorder of the cornea that causes thinning (Sedaghat et al. in Sci Rep 11(1):11971, 2021), ectasia, and irregular astigmatism, resulting in poor visual acuity that cannot be corrected with standard sphero-cylindrical spectacle lenses. One feature distinguishing keratoconic corneas is ocular aberrations, manifesting up to five or six times the amount of higher-order aberrations than a normal, healthy eye. These aberrations can cause visual disturbances even at the very early stages of the disease. Methods: In the past, a diagnosis was derived from clinical symptoms, but technological advances have revealed multiple pre-clinical features, allowing for the differentiation between keratoconic and normal eyes at a much earlier stage. These include anterior and posterior corneal surface elevations, the corneal pachymetry profile, corneal epithelial patterns, wavefront aberration metrics, and corneal biomechanics (Sedaghat et al. in Sci Rep 11(1):11971, 2021).This review discusses the aberrations associated with keratoconus, how to measure them, and treatment methods to minimize their negative influence. Conclusions: Early diagnosis can lead to early treatment and may allow for arresting progression, thereby improving the long-term prognosis. With the acceleration of refractive surgery, it is important to identify patients with keratoconus, as they are usually contraindicated for refractive surgery.
Publication DOI: | https://doi.org/10.1007/s10792-024-03118-5 |
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Divisions: | College of Health & Life Sciences > School of Optometry > Optometry College of Health & Life Sciences > School of Optometry > Optometry & Vision Science Research Group (OVSRG) College of Health & Life Sciences > School of Optometry > Vision, Hearing and Language College of Health & Life Sciences Aston University (General) |
Additional Information: | Copyright © 2024. The Author(s), under exclusive licence to Springer Nature B.V. This version of the article has been accepted for publication, after peer review and is subject to Springer Nature’s AM terms of use [https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms], but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/[DOI here when available] |
Uncontrolled Keywords: | Visual disturbance,Ectasia,Keratoconus,Keratoconus - diagnosis - etiology - therapy,Humans,Wavefront,Corneal Topography - methods,Vision Disorders,Astigmatism - diagnosis,Early detection,Higher order aberrations,Cornea,Ophthalmology |
Publication ISSN: | 1573-2630 |
Last Modified: | 25 Nov 2024 08:53 |
Date Deposited: | 07 May 2024 17:02 |
Full Text Link: | |
Related URLs: |
https://link.sp ... 792-024-03118-5
(Publisher URL) |
PURE Output Type: | Review article |
Published Date: | 2024-04-10 |
Published Online Date: | 2024-04-10 |
Accepted Date: | 2024-03-24 |
Submitted Date: | 2023-03-30 |
Authors: |
Erdinest, Nir
London, Naomi Landau, David Barbara, Ramez Barbara, Adel Naroo, Shehzad A ( 0000-0002-6373-7187) |