Sharoyko, Vladimir V., Kukaliia, Olegi N., Darvish, Diana M., Meshcheriakov, Anatolii A., Iurev, Gleb O., Andoskin, Pavel A., Penkova, Anastasia V., Ageev, Sergei V., Petukhova, Natalia V., Timoshchuk, Kirill V., Petrov, Andrey V., Akentev, Aleksandr V., Nerukh, Dmitry A., Mazur, Anton S., Maistrenko, Dmitrii N., Molchanov, Oleg E., Murin, Igor V. and Semenov, Konstantin N. (2024). Protective action of water-soluble fullerene adducts on the example of an adduct with L-arginine. Journal of Molecular Liquids, 401 ,
Abstract
We present radioprotective, antiglycating, and photoprotective properties of a water-soluble C60 fullerene derivative with L-arginine (C60-Arg) and composite films based on collagen containing C60-Arg. The synthesis of these materials is described. The identification of the synthesised materials was carried out using modern physicochemical methods of analysis. The physicochemical properties of aqueous solutions of C60-Arg, such as, particle size distribution, zeta potentials, distribution coefficient in the octan-1-ol–water system were measured. The computer simulation of the process of C60-Arg association in aqueous and isotonic solutions was carried out using Molecular Dynamics. Composite films based on collagen containing C60-Arg demonstrate significant improvement in mechanical properties, cell adhesion, and cell proliferation when the nano-modifier is added. This shows high potential for the use of the C60-Arg adduct in biomedicine.
Publication DOI: | https://doi.org/10.1016/j.molliq.2024.124702 |
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Divisions: | College of Engineering & Physical Sciences > School of Computer Science and Digital Technologies > Applied Mathematics & Data Science College of Engineering & Physical Sciences > Engineering for Health College of Engineering & Physical Sciences > School of Computer Science and Digital Technologies College of Engineering & Physical Sciences > Systems analytics research institute (SARI) College of Engineering & Physical Sciences |
Funding Information: | The work was carried out with the financial support of the Ministry of Health of the Russian Federation ‘Development of a radioprotector based on water-soluble forms of nanocarbon modified with l-amino acids’ EGISU: 123020800170-8. The equipment of the fo |
Additional Information: | Copyright © 2024, Elsevier. This accepted manuscript version is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International https://creativecommons.org/licenses/by-nc-nd/4.0/ This item is embargoed for 12 months in compliance with EPSRC funding. |
Uncontrolled Keywords: | Collagen,Fullerene,Molecular Dynamics,Photoprotector,Radioprotector,Electronic, Optical and Magnetic Materials,Atomic and Molecular Physics, and Optics,Condensed Matter Physics,Spectroscopy,Physical and Theoretical Chemistry,Materials Chemistry |
Publication ISSN: | 1873-3166 |
Data Access Statement: | Data will be made available on request <br/>Supplementary material to this article can be found online at https://doi.org/10.1016/j.molliq.2024.124702 |
Last Modified: | 07 Oct 2024 07:57 |
Date Deposited: | 25 Apr 2024 09:36 |
Full Text Link: | |
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(Scopus URL) https://www.sci ... 758X?via%3Dihub (Publisher URL) |
PURE Output Type: | Article |
Published Date: | 2024-05-01 |
Authors: |
Sharoyko, Vladimir V.
Kukaliia, Olegi N. Darvish, Diana M. Meshcheriakov, Anatolii A. Iurev, Gleb O. Andoskin, Pavel A. Penkova, Anastasia V. Ageev, Sergei V. Petukhova, Natalia V. Timoshchuk, Kirill V. Petrov, Andrey V. Akentev, Aleksandr V. Nerukh, Dmitry A. ( 0000-0001-9005-9919) Mazur, Anton S. Maistrenko, Dmitrii N. Molchanov, Oleg E. Murin, Igor V. Semenov, Konstantin N. |
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