AuNPs with Cynara scolymus leaf extracts rescue arsenic-induced neurobehavioral deficits and hippocampal tissue toxicity in Balb/c mice through D1R and D2R activation


The present study was designed to evaluate whether AuNPs (gold nanoparticles) synthesized with the Cynara scolymus (CS) leaf exert protective and/or alleviative effects on arsenic (As)-induced hippocampal neurotoxicity in mice. Neurotoxicity in mice was developed by orally treating 10 mg/kg/day sodium arsenite (NaAsO ) for 21 days. 10 µg/g AuNPs, 1.6 g/kg CS, and 10 µg/g CS-AuNPs were administered orally simultaneously with 10 mg/kg As. CS and CS-AuNPs treatments showed down-regulation of TNF-α and IL-1β levels. CS and CS-AuNPs also ameliorated apoptosis and reduced the alterations in the expression levels of D1 and D2 dopamine receptors induced by As. Simultaneous treatment with CS and CS-AuNPs improved As-induced learning, memory deficits, and motor coordination in mice assessed by water maze and locomotor tests, respectively. The results of this study provide evidence that CS-AuNPs demonstrated neuroprotective roles with antioxidant, anti-inflammatory, and anti-apoptotic effects, as well as improving D1 and D2 signaling, and eventually reversed neurobehavioral impairments. [Abstract copyright: Copyright © 2024 Elsevier B.V. All rights reserved.]

Publication DOI:
Divisions: College of Health & Life Sciences > Aston Pharmacy School
College of Health & Life Sciences > Chronic and Communicable Conditions
College of Health & Life Sciences > School of Biosciences > Cellular and Molecular Biomedicine
Funding Information: The present study was partly funded by the European Union's Horizon Europe framework program project ‘European Partnership for the Assessment of Risks from Chemicals (PARC).
Additional Information: Copyright © 2024, Elsevier B.V. This accepted manuscript version is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Uncontrolled Keywords: D2R,D1R,Arsenic,Cynara scolymus,AuNPs,Neurotoxicity
Publication ISSN: 1872-7077
Last Modified: 15 May 2024 17:51
Date Deposited: 15 Apr 2024 15:30
Full Text Link:
Related URLs: https://www.sci ... 0577?via%3Dihub (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2024-04
Published Online Date: 2024-03-15
Accepted Date: 2024-03-14
Submitted Date: 2023-09-04
Authors: Cicek, Betul
Hacimuftuoglu, Ahmet
Yeni, Yesim
Kuzucu, Mehmet
Genc, Sidika
Cetin, Ahmet
Yavuz, Emre
Danısman, Betul
Levent, Akin
Ozdokur, Kemal Volkan
Kantarcı, Mecit
Docea, Anca Oana
Siokas, Vasileios
Tsarouhas, Konstantinos
Coleman, Michael D (ORCID Profile 0000-0002-5510-6852)
Tsatsakis, Aristidis
Taghizadehghalehjoughi, Ali



Version: Accepted Version

Access Restriction: Restricted to Repository staff only until 24 March 2025.

License: Creative Commons Attribution Non-commercial No Derivatives

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