Yang, Congyi, Jia, Yifan, Yuan, Weiwen, Liao, Guoxing, Yu, Qianqian, Tang, Zhe, Ji, Yuan, Liu, Guanghui, Tan, Fangrong, Topham, Paul D. and Wang, LinGe (2024). Enhanced contrast imaging with polyamide 6/Fe(OH)3 nanofibrous scaffolds:A focus on high T1 relaxivity. Giant, 18 ,
Abstract
Nanofibers serve as widely employed tissue engineering scaffolds in diverse biomedical applications. When implanted in vivo, it is crucial for tissue engineering scaffolds to be visualizable, enabling the monitoring of their shape, position, and performance. This capability facilitates the effective assessment of implant deformations, displacements, degradations, and functionalities. However, in many biomedical imaging techniques such as magnetic resonance imaging (MRI), the contrast of tissue engineering scaffolds is often inadequate. MRI is particularly notable for its effectiveness in imaging soft tissues. Previous endeavors to enhance the contrast of tissue engineering scaffolds in MRI have involved the use of negative contrast agents (CAs). Nonetheless, negative CAs can result in artifacts, thus favoring the preference for positive CAs due to their ability to generate clearer boundaries. In this study, we successfully prepared composite polyamide 6 nanofibrous scaffolds with ultrafine dispersion Fe(OH)3 nanoparticles using electrospinning and in-situ growth techniques. The relaxation properties of the magnetic nanofibrous scaffolds confirmed the successful production of scaffolds suitable for positive imaging. In vitro cell seeding experiments demonstrated the efficient proliferation and adhesion of endothelial cells and fibroblasts. In vivo studies further revealed the biocompatibility and functionality of the scaffolds. These findings indicate that the prepared PA6/Fe(OH)3 composite nanofibrous scaffolds can enable straightforward, safe, and efficient in vivo positive contrast MRI monitoring, thereby playing a pivotal role in the integration of diagnosis and treatment within tissue engineering scaffolds.
Publication DOI: | https://doi.org/10.1016/j.giant.2024.100259 |
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Divisions: | College of Engineering & Physical Sciences > Aston Institute of Materials Research (AIMR) College of Engineering & Physical Sciences > Aston Advanced Materials College of Engineering & Physical Sciences > Engineering for Health College of Engineering & Physical Sciences > Aston Polymer Research Group College of Engineering & Physical Sciences College of Engineering & Physical Sciences > School of Infrastructure and Sustainable Engineering > Chemical Engineering & Applied Chemistry |
Funding Information: | The authors thank the financial support from the National Natural Science Foundation of China (No. U22A20316), Science and Technology Program of Guangzhou (No. 2023B03J0037), Overseas Expertise Introduction Center for Discipline Innovation (\u201C111 Cent |
Additional Information: | Copyright © 2024, The authors. This is an open access article under the CC BY NC ND license. Published by Elsevier Ltd. |
Uncontrolled Keywords: | Electrospinning,Iron-based scaffolds,Magnetic nanofibers,Magnetic resonance imaging,Polyamide 6,T positive contrast,Materials Chemistry,Surfaces, Coatings and Films,General Chemistry,Polymers and Plastics |
Publication ISSN: | 2666-5425 |
Last Modified: | 16 Aug 2024 07:17 |
Date Deposited: | 15 Apr 2024 10:42 |
Full Text Link: | |
Related URLs: |
https://www.sci ... 0249?via%3Dihub
(Publisher URL) http://www.scop ... tnerID=8YFLogxK (Scopus URL) |
PURE Output Type: | Article |
Published Date: | 2024-06 |
Published Online Date: | 2024-04-04 |
Accepted Date: | 2024-03-26 |
Authors: |
Yang, Congyi
Jia, Yifan Yuan, Weiwen Liao, Guoxing Yu, Qianqian Tang, Zhe Ji, Yuan Liu, Guanghui Tan, Fangrong Topham, Paul D. ( ![]() Wang, LinGe |
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