Water-soluble macromers based on 2-acrylamido-2-methyl-1-propanesulfonic acid sodium salt (Na-AMPS) for rapid in situ hydrogel film formation

Abstract

The in situ formation of hydrogels has potential for a number of biomedical applications but their generation via conventional polymerization techniques has a number of limitations, such as toxicity and reaction time. The use of macromers in hydrogel formulations can help overcome these limitations. In this work, we synthesized a new functionalized macromer formed via the copolymerization of 2-acrylamido-2-methylpropane sulfonic acid sodium salt (AMPS) and acid-functional monomers that can undergo a ring-opening reaction with allyl glycidyl ether (AGE) to generate the desired pendant vinyl macromer functionality. These macromers were characterized by 1H nuclear magnetic resonance (NMR) spectroscopy, Fourier transform infrared (FT-IR) spectroscopy and gel permeation chromatography (GPC) to provide evidence for successful macromer synthesis and subsequent polymerization. Using a UV-initiated crosslinking approach with poly(ethylene glycol) diacrylate (PEGDA), the hydrogels were fabricated from the macromer solution, with the gelation time being reduced from 1200 s to 10 s when compared to hydrogel formation from regular vinyl monomers. While different acidic monomers result in distinct tensile properties, hydrogels containing 2-carboxyethyl acrylate (CEA) exhibit low strength but high elongation. In contrast, those with methacrylic acid (MAA) demonstrate higher strength and lower elongation. Therefore, using a balanced combination of each is a logical approach for achieving a robust final hydrogel film. In summary, we have produced a new macromer possessing characteristics highly conducive to rapid hydrogel synthesis. This macromer approach holds potential for use in in situ hydrogel formation, where a viscous solution can be applied to the target area and subsequently hardened to its hydrogel. We envisage its application primarily in the biomedical field.

Publication DOI: https://doi.org/10.1039/d3py01416a
Divisions: College of Engineering & Physical Sciences > School of Infrastructure and Sustainable Engineering > Chemical Engineering & Applied Chemistry
College of Engineering & Physical Sciences > Aston Advanced Materials
College of Engineering & Physical Sciences > Aston Polymer Research Group
College of Engineering & Physical Sciences > Energy and Bioproducts Research Institute (EBRI)
College of Engineering & Physical Sciences
Funding Information: This work was supported by Thailand Science Research and Innovation (TSRI) (Fundamental Fund R2567B014, University Order 05791/2566), the Program Management Unit for Competitiveness (PMUC, contract number C01F660170), and Global and Frontier Research Univ
Additional Information: Copyright © The Royal Society of Chemistry, 2024. This is an accepted manuscript of an article published in Polymer Chemistry.
Publication ISSN: 1759-9962
Last Modified: 03 Jul 2024 07:20
Date Deposited: 09 Apr 2024 15:57
Full Text Link:
Related URLs: https://pubs.rs ... 4/py/d3py01416a (Publisher URL)
http://www.scop ... tnerID=8YFLogxK (Scopus URL)
PURE Output Type: Article
Published Date: 2024-03-19
Published Online Date: 2024-03-19
Accepted Date: 2024-03-18
Authors: Daengmankhong, Jinjutha
Ross, Sukunya
Pinthong, Thanyaporn
Mahasaranon, Sararat
Viyoch, Jarupa
Tighe, Brian J. (ORCID Profile 0000-0001-9601-8501)
Derry, Matthew J. (ORCID Profile 0000-0001-5010-6725)
Topham, Paul D. (ORCID Profile 0000-0003-4152-6976)
Ross, Gareth

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