Daengmankhong, Jinjutha, Ross, Sukunya, Pinthong, Thanyaporn, Mahasaranon, Sararat, Viyoch, Jarupa, Tighe, Brian J., Derry, Matthew J., Topham, Paul D. and Ross, Gareth (2024). Water-soluble macromers based on 2-acrylamido-2-methyl-1-propanesulfonic acid sodium salt (Na-AMPS) for rapid in situ hydrogel film formation. Polymer Chemistry, 15 (16), pp. 1620-1634.
Abstract
The in situ formation of hydrogels has potential for a number of biomedical applications but their generation via conventional polymerization techniques has a number of limitations, such as toxicity and reaction time. The use of macromers in hydrogel formulations can help overcome these limitations. In this work, we synthesized a new functionalized macromer formed via the copolymerization of 2-acrylamido-2-methylpropane sulfonic acid sodium salt (AMPS) and acid-functional monomers that can undergo a ring-opening reaction with allyl glycidyl ether (AGE) to generate the desired pendant vinyl macromer functionality. These macromers were characterized by 1H nuclear magnetic resonance (NMR) spectroscopy, Fourier transform infrared (FT-IR) spectroscopy and gel permeation chromatography (GPC) to provide evidence for successful macromer synthesis and subsequent polymerization. Using a UV-initiated crosslinking approach with poly(ethylene glycol) diacrylate (PEGDA), the hydrogels were fabricated from the macromer solution, with the gelation time being reduced from 1200 s to 10 s when compared to hydrogel formation from regular vinyl monomers. While different acidic monomers result in distinct tensile properties, hydrogels containing 2-carboxyethyl acrylate (CEA) exhibit low strength but high elongation. In contrast, those with methacrylic acid (MAA) demonstrate higher strength and lower elongation. Therefore, using a balanced combination of each is a logical approach for achieving a robust final hydrogel film. In summary, we have produced a new macromer possessing characteristics highly conducive to rapid hydrogel synthesis. This macromer approach holds potential for use in in situ hydrogel formation, where a viscous solution can be applied to the target area and subsequently hardened to its hydrogel. We envisage its application primarily in the biomedical field.
Publication DOI: | https://doi.org/10.1039/d3py01416a |
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Divisions: | College of Engineering & Physical Sciences > School of Infrastructure and Sustainable Engineering > Chemical Engineering & Applied Chemistry College of Engineering & Physical Sciences > Aston Advanced Materials College of Engineering & Physical Sciences > Aston Polymer Research Group College of Engineering & Physical Sciences > Energy and Bioproducts Research Institute (EBRI) College of Engineering & Physical Sciences Aston University (General) |
Funding Information: | This work was supported by Thailand Science Research and Innovation (TSRI) (Fundamental Fund R2567B014, University Order 05791/2566), the Program Management Unit for Competitiveness (PMUC, contract number C01F660170), and Global and Frontier Research Univ |
Additional Information: | Copyright © The Royal Society of Chemistry, 2024. This is an accepted manuscript of an article published in Polymer Chemistry. |
Publication ISSN: | 1759-9962 |
Last Modified: | 29 Oct 2024 16:05 |
Date Deposited: | 09 Apr 2024 15:57 |
Full Text Link: | |
Related URLs: |
https://pubs.rs ... 4/py/d3py01416a
(Publisher URL) http://www.scop ... tnerID=8YFLogxK (Scopus URL) |
PURE Output Type: | Article |
Published Date: | 2024-03-19 |
Published Online Date: | 2024-03-19 |
Accepted Date: | 2024-03-18 |
Authors: |
Daengmankhong, Jinjutha
Ross, Sukunya Pinthong, Thanyaporn Mahasaranon, Sararat Viyoch, Jarupa Tighe, Brian J. ( 0000-0001-9601-8501) Derry, Matthew J. ( 0000-0001-5010-6725) Topham, Paul D. ( 0000-0003-4152-6976) Ross, Gareth |